scholarly journals Bingeing on High‐Fat Food Enhances Evoked Dopamine Release and Reduces Dopamine Uptake in the Nucleus Accumbens

Obesity ◽  
2021 ◽  
Author(s):  
Sara R. Jones ◽  
Steve C. Fordahl
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Dopamine Uptake ◽  
High Fat

Consumption of a high fat diet affects phasic dopamine release and reuptake in the nucleus accumbens

Appetite ◽  
2010 ◽  
Vol 54 (3) ◽  
pp. 640 ◽  
Author(s):  
J.J. Cone ◽  
H.A. Robbins ◽  
J.D. Roitman ◽  
M.F. Roitman
Keyword(s):  
Nucleus Accumbens ◽  
High Fat Diet ◽  
Dopamine Release ◽  
High Fat

scholarly journals Kinetic features of the dopamine release and uptake in the dorsal and ventral striatum of rats

2020 ◽  
Vol 19 (4) ◽  
pp. 47-54
Author(s):  
Valery N. Mukhin ◽  
Ivan R. Borovets ◽  
Vadim V. Sizov ◽  
Konstantin I. Pavlov ◽  
Victor M. Klimenko
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Ventral Striatum ◽  
Dorsal Striatum ◽  
Principal Component ◽  
Dopamine Uptake ◽  
Rat Striatum ◽  
The Core ◽  
Kinetics Of

Kinetics of the evoked dopamine release and subsequent uptake in the parts of the rat striatum has not been studied sufficiently. The aim of this study is to fill this gap and to investigate kinetics of dopamine release and uptake in vivo so that comparison can be made between the dorsal and the parts of the ventral striatum and with taking into account the overlapping electrochemical factors during the subsequent analysis of voltammetry recordings. Materials and methods. The evoked wave of dopamine release and uptake in the dorsal striatum, core, and shell of the nucleus accumbens in the different groups of rats was recorded by the fast-scan cyclic voltammetry. Voltammetry recordings were subjected to principal component analysis and only the components associated with dopamine were taken for further analysis. The values of the parameters of the curves of dopamine release and uptake were defined. Then factor and variance analyses of the parameters were carried out. Results. Factor analysis showed that the set of parameters of the dopamine wave can be reduced to the 4 factors that are comparable with the variables of the known from the literature mathematical model that describes the dopamine wave based on the MichaelisMenten equation. Two of the factors and the corresponding parameters of the dopamine curve differ within the dorsal and ventral striatum. Factor 1 is associated with the parameters HL, T80_20, T20_0, slope_T20T0, which are significantly larger in the core of the nucleus accumbens. Factor 3 is associated with the parameters T50_2, AUC, FWHH, T100_80 which are significantly less in the dorsal striatum. Conclusions. The parameters of the curve of dopamine release and uptake are determined by 4 factors. Among the dopamine curve parameters, the best measures of the factors are T50_1, DAC, T100_80 и T20_0. The kinetics of stimulated dopamine release and uptake varies within the dorsal and ventral striatum. The final phase of dopamine uptake is slowed in the core of the nucleus accumbens in comparison to the shell, and the dorsal striatum. The slope of initial phase of dopamine uptake in the dorsal striatum is steeper.

Reduced phasic dopamine release and slowed dopamine uptake occur in the nucleus accumbens after a diet high in saturated but not unsaturated fat

2020 ◽  
pp. 1-13 ◽  
Author(s):  
Cherie N. Barnes ◽  
Conner W. Wallace ◽  
Brielle S. Jacobowitz ◽  
Steve C. Fordahl
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Dopamine Uptake ◽  
Unsaturated Fat

scholarly journals A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens

Pain ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Taylor A. Gee ◽  
Nathan C. Weintraub ◽  
Dong Lu ◽  
Caroline E. Phelps ◽  
Edita Navratilova ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release

β-Amyloid and Lithium Affect the Magnitude of Phasic Dopamine Release in the Shell of the Nucleus Accumbens

2021 ◽  
Vol 51 (2) ◽  
pp. 201-208
Author(s):  
V. N. Mukhin ◽  
I. R. Borovets ◽  
V. V. Sizov ◽  
K. I. Pavlov ◽  
V. M. Klimenko
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Β Amyloid

scholarly journals Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2341
Author(s):  
Conner W. Wallace ◽  
Nari S. Beatty ◽  
Sarah A. Hutcherson ◽  
Heather A. Emmons ◽  
Madison C. Loudermilt ◽  
...  
Keyword(s):  
Weight Loss ◽  
Nucleus Accumbens ◽  
High Fat Diet ◽  
Elevated Plus Maze ◽  
High Fat ◽  
Food Cravings ◽  
Fast Scan Cyclic Voltammetry ◽  
Diet Induced Obesity ◽  
Plus Maze ◽  
Weight Loss Interventions

Diet-induced obesity reduces dopaminergic neurotransmission in the nucleus accumbens (NAc), and stressful weight loss interventions could promote cravings for palatable foods high in fat and sugar that stimulate dopamine. Activation of κ-opioid receptors (KORs) reduces synaptic dopamine, but contribution of KORs to lower dopamine tone after dietary changes is unknown. Therefore, the purpose of this study was to determine the function of KORs in C57BL/6 mice that consumed a 60% high-fat diet (HFD) for six weeks followed by replacement of HFD with a control 10% fat diet for one day or one week. HFD replacement induced voluntary caloric restriction and weight loss. However, fast-scan cyclic voltammetry revealed no differences in baseline dopamine parameters, whereas sex effects were revealed during KOR stimulation. NAc core dopamine release was reduced by KOR agonism after one day of HFD replacement in females but after one week of HFD replacement in males. Further, elevated plus-maze testing revealed no diet effects during HFD replacement on overt anxiety. These results suggest that KORs reduce NAc dopamine tone and increase food-related anxiety during dietary weight loss interventions that could subsequently promote palatable food cravings and inhibit weight loss.

scholarly journals Stimulation-Evoked Dopamine Release in the Nucleus Accumbens Following Cocaine Administration in Rats Perinatally Exposed to Polychlorinated Biphenyls

2013 ◽  
Vol 136 (1) ◽  
pp. 144-153 ◽  
Author(s):  
Jenna R. Fielding ◽  
Tiffany D. Rogers ◽  
Abby E. Meyer ◽  
Mellessa M. Miller ◽  
Jenna L. Nelms ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Polychlorinated Biphenyls ◽  
Dopamine Release ◽  
Cocaine Administration
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