Increase in dopamine release from the nucleus accumbens in response to feeding: a model to study interactions between drugs and naturally activated dopaminergic neurons in the rat brain

1994 ◽  
Vol 349 (3) ◽  
pp. 230-235 ◽  
Author(s):  
Ben H. C. Westerink ◽  
Ard Teisman ◽  
Jan B. de Vries
Keyword(s):  
Nucleus Accumbens ◽  
Rat Brain ◽  
Dopaminergic Neurons ◽  
Dopamine Release

scholarly journals Activation of TRPV1 in the VTA Excites Dopaminergic Neurons and Increases Chemical- and Noxious-Induced Dopamine Release in the Nucleus Accumbens

2004 ◽  
Vol 30 (5) ◽  
pp. 864-870 ◽  
Author(s):  
Silvia Marinelli ◽  
Tiziana Pascucci ◽  
Giorgio Bernardi ◽  
Stefano Puglisi-Allegra ◽  
Nicola B Mercuri
Keyword(s):  
Nucleus Accumbens ◽  
Dopaminergic Neurons ◽  
Dopamine Release

Feeding increases dopamine metabolism in the rat brain

Science ◽  
1980 ◽  
Vol 208 (4448) ◽  
pp. 1168-1170 ◽  
Author(s):  
TG Heffner ◽  
JA Hartman ◽  
LS Seiden
Keyword(s):  
Nucleus Accumbens ◽  
Food Intake ◽  
Rat Brain ◽  
Nerve Terminal ◽  
Dopaminergic Neurons ◽  
Corpus Striatum ◽  
Dopamine Metabolism ◽  
Posterior Hypothalamus ◽  
Central Neurons ◽  
Neurochemical Change

Feeding induced by food deprivation is accompanied by an increased production of the dopamine metabolite 3,4-dihydroxyphenylacetic acid in the brains of rats. This neurochemical change occurs in the nucleus accumbens, the posterior hypothalamus, and the amygdala but not in other dopaminergic nerve terminal fields such as the corpus striatum. These results indicate that the release of dopamine from particular groups of central neurons is increased during feeding and suggest that anatomically distinct subgroups of central dopaminergic neurons serve different roles in the regulation of food intake.

scholarly journals Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Pedro Espinosa ◽  
Roxana A. Silva ◽  
Nicole K. Sanguinetti ◽  
Francisca C. Venegas ◽  
Raul Riquelme ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Tyrosine Hydroxylase ◽  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Dopaminergic Neurons ◽  
Dopamine Release ◽  
Male Rats ◽  
Midbrain Dopaminergic Neurons ◽  
Dopamine Content ◽  
Ventral Tegmental

We sought to determine the long-term changes produced by neonatal sex hormone administration on the functioning of midbrain dopaminergic neurons in adult male rats. Sprague-Dawley rats were injected subcutaneously at postnatal day 1 and were assigned to the following experimental groups: TP (testosterone propionate of 1.0 mg/50 μL); DHT (dihydrotestosterone of 1.0 mg/50 μL); EV (estradiol valerate of 0.1 mg/50 μL); and control (sesame oil of 50 μL). At postnatal day 60, neurochemical studies were performed to determine dopamine content in substantia nigra-ventral tegmental area and dopamine release in nucleus accumbens. Molecular (mRNA expression of tyrosine hydroxylase) and cellular (tyrosine hydroxylase immunoreactivity) studies were also performed. We found increased dopamine content in substantia nigra-ventral tegmental area of TP and EV rats, in addition to increased dopamine release in nucleus accumbens. However, neonatal exposure to DHT, a nonaromatizable androgen, did not affect midbrain dopaminergic neurons. Correspondingly, compared to control rats, levels of tyrosine hydroxylase mRNA and protein were significantly increased in TP and EV rats but not in DHT rats, as determined by qPCR and immunohistochemistry, respectively. Our results suggest an estrogenic mechanism involving increased tyrosine hydroxylase expression, either by direct estrogenic action or by aromatization of testosterone to estradiol in substantia nigra-ventral tegmental area.

scholarly journals Effects of ginseng saponin on acute cocaine-induced alterations in evoked dopamine release and uptake in rat brain nucleus accumbens

2009 ◽  
Vol 1248 ◽  
pp. 184-190 ◽  
Author(s):  
Seong-Yeol Nah ◽  
Kamal S. Bhatia ◽  
Johnnie Lyles ◽  
Everett H. Ellinwood ◽  
Tong H. Lee
Keyword(s):  
Nucleus Accumbens ◽  
Rat Brain ◽  
Dopamine Release ◽  
Ginseng Saponin ◽  
Brain Nucleus

scholarly journals A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens

Pain ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Taylor A. Gee ◽  
Nathan C. Weintraub ◽  
Dong Lu ◽  
Caroline E. Phelps ◽  
Edita Navratilova ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release
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