Patterns of weight change in a weight gain prevention study for young adults

Obesity ◽  
2021 ◽  
Author(s):  
Jacqueline F. Hayes ◽  
Deborah F. Tate ◽  
Mark A. Espeland ◽  
Jessica Gokee LaRose ◽  
Amy A. Gorin ◽  
...  
Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Beatrice A Golomb ◽  
Hayley J Koslik ◽  
Alexis K Bui

Background and Goal: Sleep problems were significantly increased on simvastatin ( simva ) (but not pravastatin) vs placebo in the UCSD Statin Study. Sleep problems on simva predicted glucose rise. Weight gain has also been reported as a statin side effect. We sought to capitalize on existing data to assess whether sleep problems on simva related to weight gain in men. Method: 442 men without known diabetes or CVD were randomized to simva 20mg or placebo for 6 mon. One hundred eighty and 186 completed single-item self-rating of change in sleep problems vs baseline ( Δslpprob ). Weight (lb) was measured at baseline and 6 mon. Missing 6 mon values were imputed. Analyses: A. Regressions stratified by treatment assessed prediction of weight change by Δslpprob, adjusted for baseline weight. B. Regressions assessed prediction of weight change by the interaction term of simva (vs placebo) x Δslpprob, adjusted for the components of the interaction and baseline weight. Since age-related muscle loss may complicate weight change in elderly; and young adults have low vulnerability to metabolic problems, analyses were repeated excluding these groups. Results: A. Increased sleep problems on simva predicted weight gain (significant), but on placebo predicted weight loss (nonsignificant). B. The Δslpprob x simva interaction term significantly predicted weight gain. When that was parceled out, simva, outside of the sleep relationship, negatively predicted weight change. Exclusion of young adults and elderly strengthened significance of findings (Table). Discussion: Sleep problems, which differentially arise on simva, differentially predict weight gain on simva. This expands the metabolic effects to which sleep problems on simva may contribute and might possibly favor mediation by sleep apnea (a reported complication of simva). Once the sleep problem effect is considered, simva use predicted weight loss . The relative contribution of fat vs muscle loss (vs other) requires exploration.


Obesity ◽  
2020 ◽  
Vol 28 (12) ◽  
pp. 2323-2330
Author(s):  
Rena R. Wing ◽  
Mark A. Espeland ◽  
Deborah F. Tate ◽  
Letitia H. Perdue ◽  
Judy Bahnson ◽  
...  

2015 ◽  
Vol 13 (2) ◽  
pp. 205-213 ◽  
Author(s):  
Stacey G Moe ◽  
Leslie A Lytle ◽  
Marilyn S Nanney ◽  
Jennifer A Linde ◽  
Melissa N Laska

2019 ◽  
Vol 51 (2) ◽  
pp. 205-216 ◽  
Author(s):  
Daniel T. Halperin ◽  
Jeffrey Laux ◽  
Carlos LeFranc-García ◽  
Coloma Araujo ◽  
Cristina Palacios

Trials ◽  
2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Deborah F Tate ◽  
Jessica G LaRose ◽  
Leah P Griffin ◽  
Karen E Erickson ◽  
Erica F Robichaud ◽  
...  

Obesity ◽  
2020 ◽  
Vol 28 (3) ◽  
pp. 521-528
Author(s):  
Rena R. Wing ◽  
Gregory B. Russell ◽  
Deborah F. Tate ◽  
Mark A. Espeland ◽  
Jessica Gokee LaRose ◽  
...  

2012 ◽  
Vol 16 (10) ◽  
pp. 1796-1800
Author(s):  
Joyce W Tang ◽  
Norrina Allen ◽  
Peter de Chavez ◽  
David C Goff ◽  
Catarina I Kiefe ◽  
...  

AbstractObjectiveHealth-care access is associated with improved control of multiple chronic diseases, but the association between health-care access and weight change is unclear. The present study aims to test the association between health-care access and weight change.DesignThe Coronary Artery Risk Development in Young Adults (CARDIA) Study is a multicentre population-based prospective study. Weight change was calculated at 3 and 13 years after CARDIA year 7 (1992–1993). Health-care access was defined as no barriers or one or more barriers to access (health insurance gap, no usual source of care, not seeking care due to expense). Intermediary variables evaluated included history of dieting and use of diet pills, meal replacements or weight-control programmes.SettingFour cities in the USA.SubjectsParticipants were aged 18–30 years at baseline (1985–1986). Analyses include 3922 black and white men and women with relevant data from CARDIA years 7, 10 and 20 (1992–1993, 1995–1996 and 2005–2006, respectively).ResultsMean weight change was +2·22 kg (+4·9 lb) by 3 years and +8·48 kg (+18·7 lb) by 13 years, with no differences by health-care access. Being on a weight-reducing diet was not consistently associated with health-care access across examinations. Use of diet pills, meal replacements or organized weight-control programmes was low, and did not vary by health-care access.ConclusionsWeight gain was high irrespective of health-care access. Public health and clinical approaches are needed to address weight gain.


2008 ◽  
Vol 24 (4) ◽  
pp. 586-595 ◽  
Author(s):  
D. A. Sherrill-Mittleman ◽  
L. M. Klesges ◽  
J. Q. Lanctot ◽  
M. B. Stockton ◽  
R. C. Klesges

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