Expression of hypoxia-associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene

2011 ◽  
Vol 225 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Oskar Koperek ◽  
Oliver Bergner ◽  
Bettina Pichlhöfer ◽  
Felicitas Oberndorfer ◽  
Johannes A Hainfellner ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Somatic Mutations ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Vhl Gene ◽  
Node Metastasis ◽  
Associated Proteins ◽  
Desmoplastic Stroma

scholarly journals Patients with familial non-medullary thyroid cancer have an outcome similar to that of patients with sporadic papillary thyroid tumors

2011 ◽  
Vol 55 (3) ◽  
pp. 219-223 ◽  
Author(s):  
Fabián Pitoia ◽  
Graciela Cross ◽  
María E. Salvai ◽  
Erika Abelleira ◽  
Hugo Niepomniszcze
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Medullary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Clinical Behavior ◽  
Medullary Thyroid ◽  
Persistent Disease ◽  
Node Metastasis ◽  
Baseline Characteristics

OBJECTIVE:The purpose of this study was to determine whether familial non-medullary thyroid cancer (FNMTC) is more aggressive than sporadic thyroid cancer. SUBJECTS AND METHODS: We compared the clinical behavior and outcome of 16 subjects with FNMTC from 7 unrelated kindred with those observed in 160 subjects with sporadic PTC (SPTC) from our database. RESULTS: The only different baseline characteristics observed between both groups were: bilateral malignancy, 38% vs. 24%, respectively (p = 0.03), and lymph node metastasis, 56.2% vs. 39%, respectively (p = 0.01). Considering the outcome, in the FNMTC, 9 (56.2%) patients were rendered free of disease, one patient died from thyroid cancer (6%), and 6/16 (37.5%) had persistent disease. In the SPTC Group, 87 (54%) patients were considered free of disease, 11 (7%) died due to PTC, and 62 (38%) had persistent disease (p = ns). CONCLUSIONS: Despite the higher incidence of lymph node metastasis in FNMTC patients this situation seemed not to alter the compared outcome.

scholarly journals Preoperative serum inflammation-based scores in medullary thyroid cancer

2021 ◽  
Author(s):  
Ana Figueiredo ◽  
Susana Esteves ◽  
Margarida Maria Moura ◽  
Pedro Marques ◽  
Joana Simões-Pereira ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Medullary Thyroid Cancer ◽  
Univariate Analysis ◽  
Extrathyroidal Extension ◽  
Medullary Thyroid ◽  
Lymphocyte Ratio ◽  
Node Metastasis

Abstract Introduction: Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are prognostic factors in several tumours, however little is known in medullary thyroid cancer (MTC). Objective: To evaluate the association between preoperative NLR, PLR and SII with MTC clinicopathological and molecular features, and their predictive value for lymph-node and distant metastasis. Methods: We retrospectively analysed 75 patients with MTC who underwent surgery at our institution. Results: In our cohort, 56% were females, the median age at diagnosis was 57 years (44–69), the median tumour diameter was 25mm (15–50); 21.3% were multifocal and 34.7% had extrathyroidal extension. Fibrosis was present in 30 of the 37 analysed samples; RET somatic status was assessed in 35 cases and 21 harboured a mutation. Lymph-node and distant metastasis were observed in 36 (48.0%) and 8 (10.7%), respectively. Higher NLR was associated with preoperative calcitonin, angioinvasion, extrathyroidal extension, moderate/severe fibrosis; higher PLR was associated to extrathyroidal extension and advanced T stages; lower SII and NLR were associated with biochemical cure after surgery. Increased PLR, NLR and SII were associated with advanced MTC stages. In the univariate analysis, only NLR was associated with lymph-node metastasis (odds ratio (OR) = 2.69, 95% confidence interval (CI): 1.50–5.84; p = 0.004); however, in the multivariate model, NLR was no longer a predictive factor for lymph-node metastasis. Conclusion: None of these serum inflammatory markers predicted the occurrence of distant metastasis. In conclusion, NLR, PLR and SII may indicate aggressive MTC disease, but do not predict lymph-node or distant metastasis.

Exceptionality of Distant Metastases in Node-Negative Hereditary and Sporadic Medullary Thyroid Cancer: Lessons Learned

2021 ◽  
Author(s):  
Andreas Machens ◽  
Kerstin Lorenz ◽  
Frank Weber ◽  
Henning Dralle
Keyword(s):  
Risk Factors ◽  
Thyroid Cancer ◽  
Lymph Node ◽  
Medullary Thyroid Cancer ◽  
Distant Metastases ◽  
Node Negative ◽  
Medullary Thyroid ◽  
Primary Tumor Size ◽  
Node Metastasis ◽  
Node Positive

Abstract Context Risk factors of lymph node and distant metastases have rarely been analyzed in hereditary and sporadic medullary thyroid cancer (MTC) using large genetic-clinical data sets. Objective This comprehensive investigation aimed to explore risk factors of lymph node and distant metastases and interdependencies between age at thyroidectomy, primary tumor size, lymph node metastasis and distant metastasis in patients with hereditary and sporadic MTC. Methods Comparative analyses of risk factors of metastasis, stratified by hereditary MTC (four mutational risk categories) and sporadic MTC. Results There were 1115 patients with hereditary MTC (307 patients) or sporadic MTC (808 patients). Age at thyroidectomy increased proportionately from 12.2, 22.7, 34.3, and 49.8 years for patients with decreasing mutational risk, as compared to 52.1 years for patients with sporadic MTC. Metastatic primary tumors overall were 10.7–19.4 mm larger in node-positive patients and 15.9–19.3 mm larger in distant metastatic patients at thyroidectomy than nonmetastatic tumors. Distant metastases were noted in 13–50% of node-positive vs. 0% of node-negative hereditary MTC, and in 23.5% of node-positive vs. 1.7% of node-negative sporadic MTC. In multivariable logistic regression analysis for sporadic MTC, lymph node metastasis contributed to distant metastasis (odds ratio 12.4) more than primary tumor size (odds ratios of 7.8, 5.5 and 2.4 for tumors measuring >60, 41–60 and 21–40 mm). Conclusions When thyroidectomy is performed before lymph node metastases have developed, distant metastases are exceptional, both in patients with hereditary MTC, irrespective of the level of mutational risk, and patients with sporadic MTC.

TSHR rs2288496 associated with thyroid hormone and predict the occurrence of lymph node metastasis of papillary thyroid cancer

2019 ◽  
Vol 26 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Xuan Su ◽  
Li-Wen Lin ◽  
Jie-Ling Weng ◽  
Shu-Wei Chen ◽  
Xin-Hua Yang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Thyroid Hormone ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Node Metastasis
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