Exercise capacity in long-term survivors of pediatric cancer: An analysis from the cardiac risk factors in childhood cancer survivors study

2012 ◽  
Vol 60 (4) ◽  
pp. 663-668 ◽  
Author(s):  
Angela M. Miller ◽  
Gabriela Lopez-Mitnik ◽  
Gabriel Somarriba ◽  
Stuart R. Lipsitz ◽  
Andrea S. Hinkle ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Exercise Capacity ◽  
Pediatric Cancer ◽  
Childhood Cancer Survivors ◽  
Cardiac Risk ◽  
Cardiac Risk Factors ◽  
Long Term Survivors

Longitudinal evaluation of alanine aminotransferase after treatment for childhood cancer. A report from the St. Jude Lifetime Cohort Study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e22525-e22525
Author(s):  
Daniel M. Green ◽  
Mingjuan Wang ◽  
Matthew J. Krasin ◽  
Deokumar Srivastava ◽  
Mary V. Relling ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Cancer ◽  
Alanine Aminotransferase ◽  
Childhood Cancer Survivors ◽  
Hematopoietic Stem ◽  
History Of ◽  
Normal Alt ◽  
Treatment Designs ◽  
Long Term Survivors

e22525 Background: Many childhood cancer survivors have been exposed to hepatotoxic agents. We assessed longitudinal hepatic injury, using alanine aminotransferase (ALT) elevation, and associated factors in a large cohort of long-term survivors. Methods: We evaluated SJLIFE participants ( > 10 years post-diagnosis, age ≥18 years) who had two or more determinations of ALT (T1 baseline, T2 last evaluation). Elevated ALT was defined as ALT > Upper Limit of Normal (ULN, 30 IU/mL for males and 19 IU/mL for females). Elastic net was used to perform model selection for elevated ALT at T2. Modified Poisson regression was used to identify risk factors for elevated ALT at T2. Results: Serial ALT assessments were available for 1941 survivors (49.6% female, 82.2% non-Hispanic white [NHW]). Their median age at diagnosis and T1 were 7.6 years (interquartile range [IQR] = 3.4-13.5) and 31.7 years (IQR = 26.1-38.1), respectively. Elapsed time from diagnosis to T1, and T1 to T2, were 23.3 years (IQR = 17.8-29.6) and 5.2 years (IQR = 4.4-5.7). ALT was normal at T1 and T2 in 45.7%, and persistently (25.9%) or newly (11.7%) abnormal in 37.6%. Compared to those with normal ALT at T1, those with elevated ALT at T2 were more likely to have NHW race/ethnicity, treatment with busulfan, increasing volume of the liver exposed to 10 Gray (Gy) or more (V10), body mass index (BMI) > 25 kg/m2, hepatitis C, metabolic syndrome, or treatment with atorvastatin, rosuvastatin or simvastatin at T2. History of hematopoietic stem cell transplantation (HSCT), but not busulfan, were additional risk factors included in the models for V15 and V20 (Table). Conclusions: Demographic, treatment, lifestyle, and non-oncologic interventions increase the risk for ALT elevation in survivors. These results may guide future treatment designs and lifestyle interventions. [Table: see text]

Understanding predictors of continued long-term pediatric cancer care across the region: A report from the Consortium for New England Childhood Cancer Survivors

2017 ◽  
Vol 64 (10) ◽  
pp. e26564 ◽  
Author(s):  
Jennifer J. G. Welch ◽  
Lisa B. Kenney ◽  
Priya Hirway ◽  
G. Naheed Usmani ◽  
Nina Kadan-Lottick ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
New England ◽  
Childhood Cancer ◽  
Pediatric Cancer ◽  
Cancer Care ◽  
Childhood Cancer Survivors

Cardiovascular Disease as a Long-Term Complication of Treatment for Testicular Cancer

2003 ◽  
Vol 21 (8) ◽  
pp. 1513-1523 ◽  
Author(s):  
R.A. Huddart ◽  
A. Norman ◽  
M. Shahidi ◽  
A. Horwich ◽  
D. Coward ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Testicular Cancer ◽  
Cardiac Risk ◽  
Mortality Data ◽  
Resident Male ◽  
Cardiac Risk Factors ◽  
Long Term Survivors

Purpose: To assess the risk of cardiovascular morbidity and cardiac risk factors in long-term survivors of testicular cancer according to treatment received. Patients and Methods: All resident male patients registered in the United Kingdom between 1982 and 1992 attending for follow-up were eligible for recruitment. Patients completed a current health questionnaire and underwent clinical review, along with hematologic, biochemical, and hormonal profiles. For patients not under routine review, follow-up information was sought from their general practitioner and mortality data were sought from the Office of National Statistics. Descriptive analysis was performed on all variables and comparisons were made among patients treated by orchidectomy and follow-up only, chemotherapy alone (C), radiotherapy alone (RT), and radiotherapy and chemotherapy (C/RT). Results: Data on cardiovascular events were available on 992 patients. After a median follow-up of 10.2 years, 68 events had been reported, including 18 deaths. After adjusting for age, increased risk for cardiac events was seen after C (relative risk [RR] = 2.59; 95% confidence interval [CI], 1.15 to 5.84; P = .022), RT (RR = 2.40; 95% CI, 1.04 to 5.45; P = .036), and C/RT (RR = 2.78; 95% CI, 1.09 to 7.07; P = .032). There were no significant differences in cardiac risk factors. On multivariate analysis, age, treatment group, free thyroxine, protein, and magnesium levels were associated with cardiovascular disease. Conclusion: In long-term survivors of testicular cancer, we observed a two-fold or greater risk of developing cardiovascular disease. This was not due to increases in cardiac risk factors, which suggests a direct or indirect treatment effect. These data support the continued research into the minimization of treatment in good-prognosis testicular cancer.

Prevalence and risk factors for vitamin D deficiency in long‐term childhood cancer survivors

2021 ◽  
Author(s):  
Rusha Bhandari ◽  
Jennifer Berano Teh ◽  
Claudia Herrera ◽  
Meagan Echevarria ◽  
Lanie Lindenfeld ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Vitamin D Deficiency ◽  
Childhood Cancer Survivors

Cardiovascular risk factors and arterial wall properties in childhood cancer survivors; a long-term follow-up

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 8090-8090
Author(s):  
M. M. Geenen ◽  
E. De Groot ◽  
F. E. Van Leeuwen ◽  
J. J. Kastelein ◽  
P. J. Bakker
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cardiovascular Risk Factors ◽  
Arterial Wall ◽  
Childhood Cancer Survivors ◽  
Long Term Follow Up

Risk factors for suicidal ideation in a large, registry-based sample of adult long-term childhood cancer survivors

2020 ◽  
Vol 265 ◽  
pp. 351-356
Author(s):  
Mareike Ernst ◽  
Elmar Brähler ◽  
Philipp S. Wild ◽  
Claus Jünger ◽  
Jörg Faber ◽  
...  
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors
Sign in / Sign up

Export Citation Format

Share Document