Late effects in pediatric Hodgkin lymphoma survivors after uniform treatment with ABVD with or without radiotherapy

2021 ◽  
Author(s):  
Abhenil Mittal ◽  
Sainath Bhethanabhotla ◽  
Shuvadeep Ganguly ◽  
Sreenivas Vishnubhatla ◽  
Rajesh Khadgawat ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Late Effects ◽  
Pediatric Hodgkin Lymphoma ◽  
Lymphoma Survivors ◽  
Uniform Treatment

scholarly journals Influence of new late effects on quality of life over time in Hodgkin lymphoma Survivors: a longitudinal survey study

2013 ◽  
Vol 24 (1) ◽  
pp. 226-230 ◽  
Author(s):  
N. Khimani ◽  
Y.-H. Chen ◽  
P.M. Mauch ◽  
C. Recklitis ◽  
L. Diller ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hodgkin Lymphoma ◽  
Late Effects ◽  
Longitudinal Survey ◽  
Survey Study ◽  
Lymphoma Survivors ◽  
Over Time

scholarly journals Pediatric Hodgkin lymphoma survivors at negligible risk for significant bone mineral density deficits

2008 ◽  
Vol 52 (4) ◽  
pp. 516-521 ◽  
Author(s):  
Sue C. Kaste ◽  
Monika L. Metzger ◽  
Anum Minhas ◽  
Zang Xiong ◽  
Shesh N. Rai ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Hodgkin Lymphoma ◽  
Bone Mineral ◽  
Mineral Density ◽  
Significant Bone Mineral Density ◽  
Pediatric Hodgkin Lymphoma ◽  
Lymphoma Survivors

scholarly journals Pulmonary dysfunction in pediatric Hodgkin Lymphoma survivors Praneetha M, R. Seth, Aditya Gupta , Jagdish P Meena, Sumita Gupta, S K Kabra

2020 ◽  
Vol 5 (4) ◽  
pp. S12
Author(s):  
Rachna Seth ◽  
Sushil Kumar. Kabra ◽  
Aditya Gupta ◽  
Jagdish P. . Meena ◽  
Sumita Gupta ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Pulmonary Dysfunction ◽  
Pediatric Hodgkin Lymphoma ◽  
Lymphoma Survivors

scholarly journals Prevalence of Function‐Limiting Late Effects in Hodgkin Lymphoma Survivors

PM&R ◽  
2021 ◽  
Author(s):  
Nabela Enam ◽  
Kathy Chou ◽  
Michael D. Stubblefield
Keyword(s):  
Hodgkin Lymphoma ◽  
Late Effects ◽  
Lymphoma Survivors

Risk-adapted therapy for pediatric Hodgkin lymphoma (HL) results in lower risk of late effects: a report from the Childhood Cancer Survivor Study (CCSS).

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 10510-10510 ◽  
Author(s):  
Kevin C. Oeffinger ◽  
Kayla Stratton ◽  
Melissa M. Hudson ◽  
Wendy Leisenring ◽  
Rebecca M. Howell ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Hodgkin Lymphoma ◽  
Cancer Survivor ◽  
Late Effects ◽  
Lower Risk ◽  
Childhood Cancer Survivor ◽  
Pediatric Hodgkin Lymphoma ◽  
Childhood Cancer Survivor Study

scholarly journals Pediatric Hodgkin lymphoma: trade-offs between short- and long-term mortality risks

Blood ◽  
2012 ◽  
Vol 120 (11) ◽  
pp. 2195-2202 ◽  
Author(s):  
Jennifer M. Yeh ◽  
Lisa Diller
Keyword(s):  
Life Expectancy ◽  
Hodgkin Lymphoma ◽  
Late Effects ◽  
Survival Rates ◽  
Treatment Strategies ◽  
Careful Consideration ◽  
Term Survival ◽  
Pediatric Hodgkin Lymphoma ◽  
Trade Offs

Abstract As pediatric Hodgkin lymphoma (HL) survival rates approach > 95%, treatment decisions are increasingly based on minimizing late effects. Using a model-based approach, we explored whether the addition of radiotherapy contributes to improved overall long-term survival. We developed a state-transition model to simulate the lifetime HL clinical course, and we compared 2 treatment strategies: chemotherapy alone (CT) and chemoradiotherapy (CRT). Data on HL relapse, late recurrence, and excess second cancer and cardiac late-effects mortality were estimated from the published literature and databases. Outcomes included conditional life expectancy, cause-specific mortality, and proportion alive at age 50. For a hypothetical cohort of HL patients (diagnosis age 15), conditional life expectancy was 57.2 years with CT compared with 56.4 years with CRT. Estimated lifetime HL mortality risk was 3.6% with CT versus 2.2% with CRT. In contrast, combined risk of excess late-effects mortality was lower for CT (1.8% vs 7.4% with CRT). Among those alive at age 50, only 9.2% of those initially treated with CT were at risk for radiation-related late effects (100% for CRT). Initial treatment with CT may be associated with longer average per-person life expectancy. These results support the need for careful consideration of the risk-benefit profile of radiation as frontline therapy in pediatric patients.

The Evolution of Pediatric Hodgkin Lymphoma Therapy: Contemporary Protocols Significantly Reduce Radiation Exposure of Normal Tissues

2014 ◽  
Vol 226 (02) ◽  
Author(s):  
R Zhou ◽  
A Ng ◽  
R Weathers ◽  
A McDonald ◽  
W Leisenring ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Hodgkin Lymphoma ◽  
Reduce Radiation Exposure ◽  
Normal Tissues ◽  
Pediatric Hodgkin Lymphoma ◽  
Lymphoma Therapy
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