Acute megakaryoblastic leukemia mimicking a disseminated tumor

2021 ◽  
Author(s):  
Suet Ying Sophia Lam ◽  
Shau Yin Ha ◽  
Jason Chi Chiu So ◽  
Daniel Ka Leung Cheuk ◽  
Terry Tin Wai Chow
Keyword(s):  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia

scholarly journals Identification and Characterization of Megakaryoblasts in Acute Megakaryoblastic Leukemia in a Dog

1990 ◽  
Vol 27 (3) ◽  
pp. 212-214 ◽  
Author(s):  
J. Messick ◽  
M. Carothers ◽  
M. Wellman
Keyword(s):  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Identification And Characterization

Characteristics of a Cell Line Established from a Case of Acute Megakaryoblastic Leukemia

1997 ◽  
Vol 98 (1) ◽  
pp. 26-31 ◽  
Author(s):  
L.F. Skinnider ◽  
P. Pabello ◽  
C.Y Zheng
Keyword(s):  
Cell Line ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
A Cell

scholarly journals ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells

Blood ◽  
2009 ◽  
Vol 113 (14) ◽  
pp. 3337-3347 ◽  
Author(s):  
Monika J. Stankiewicz ◽  
John D. Crispino
Keyword(s):  
Human Cancer ◽  
Fetal Liver ◽  
Chromosome 21 ◽  
Wild Type ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Human Chromosome 21 ◽  
Ets Proteins ◽  
Differentiation Block ◽  
Stat Pathway

Abstract ETS2 and ERG are transcription factors, encoded on human chromosome 21 (Hsa21), that have been implicated in human cancer. People with Down syndrome (DS), who are trisomic for Hsa21, are predisposed to acute megakaryoblastic leukemia (AMKL). DS-AMKL blasts harbor a mutation in GATA1, which leads to loss of full-length protein but expression of the GATA-1s isoform. To assess the consequences of ETS protein misexpression on megakaryopoiesis, we expressed ETS2, ERG, and the related protein FLI-1 in wild-type and Gata1 mutant murine fetal liver progenitors. These studies revealed that ETS2, ERG, and FLI-1 facilitated the expansion of megakaryocytes from wild-type, Gata1-knockdown, and Gata1s knockin progenitors, but none of the genes could overcome the differentiation block characteristic of the Gata1-knockdown megakaryocytes. Although overexpression of ETS proteins increased the proportion of CD41+ cells generated from Gata1s-knockin progenitors, their expression led to a significant reduction in the more mature CD42 fraction. Serial replating assays revealed that overexpression of ERG or FLI-1 immortalized Gata1-knockdown and Gata1s knockin, but not wild-type, fetal liver progenitors. Immortalization was accompanied by activation of the JAK/STAT pathway, commonly seen in megakaryocytic malignancies. These findings provide evidence for synergy between alterations in GATA-1 and overexpression of ETS proteins in aberrant megakaryopoiesis.

scholarly journals Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down's syndrome

Leukemia ◽  
2003 ◽  
Vol 17 (11) ◽  
pp. 2250-2252 ◽  
Author(s):  
Y Hirose ◽  
K Kudo ◽  
H Kiyoi ◽  
Y Hayashi ◽  
T Naoe ◽  
...  
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Comprehensive Analysis ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Gene Alterations

scholarly journals Development of Acute Megakaryoblastic Leukemia with Isochromosome (12p) after a Primary Mediastinal Germ Cell Tumor in Korea

2011 ◽  
Vol 26 (8) ◽  
pp. 1099 ◽  
Author(s):  
Nae Yu ◽  
Hye Ryoun Kim ◽  
Young-Joo Cha ◽  
Eun Kyung Park ◽  
Jeong Wook Kim
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Isochromosome 12P ◽  
Mediastinal Germ Cell Tumor

Prognostic impact of specific molecular profiles in pediatric acute megakaryoblastic leukemia in non-Down syndrome

2017 ◽  
Vol 56 (5) ◽  
pp. 394-404 ◽  
Author(s):  
Yusuke Hara ◽  
Norio Shiba ◽  
Kentaro Ohki ◽  
Ken Tabuchi ◽  
Genki Yamato ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Prognostic Impact ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Molecular Profiles

Acute Megakaryoblastic Leukemia

2014 ◽  
pp. 43-46
Author(s):  
Jean-Pierre Bourquin ◽  
Shai Izraeli
Keyword(s):  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia
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