UPLC–MS/MS method for the determination of the herb composition of Tangshen formula and the in vivo pharmacokinetics of its metabolites in rat plasma

2021 ◽  
Author(s):  
Yu Yao ◽  
Ying‐Chao Yu ◽  
Meng‐Ru Cai ◽  
Zhi‐Qin Zhang ◽  
Jie Bai ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Tangshen Formula ◽  
In Vivo Pharmacokinetics

A sensitive HPLC-FL method to simultaneously determine febuxostat and diclofenac in rat plasma: assessment of metabolic drug interactions in vitro and in vivo

2020 ◽  
Vol 12 (16) ◽  
pp. 2166-2175 ◽  
Author(s):  
Dong-Gyun Han ◽  
Kyu-Sang Kim ◽  
Seong-Wook Seo ◽  
Young Mee Baek ◽  
Yunjin Jung ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Drug Interactions ◽  
Simultaneous Determination ◽  
Small Volume ◽  
Rat Plasma ◽  
Metabolic Drug ◽  
Simple Sample Preparation

We developed a sensitive, simple and validated HPLC-FL method for simultaneous determination of FEB and DIC in rat plasma. The method requires a relatively small volume of sample, has simple sample preparation and excellent sensitivity.

Determination of geniposidic acid in rat plasma by LC–MS/MS and its application to in vivo pharmacokinetic studies

2012 ◽  
Vol 887-888 ◽  
pp. 138-142 ◽  
Author(s):  
Xia Zheng ◽  
Xiao-Tao Huang ◽  
Neng Li ◽  
Ying-Yi Li ◽  
Sui-Qing Mi ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Geniposidic Acid

scholarly journals Development of a new HPLC method for wogonin in rat plasma: Compatibility of standard and test samples

2017 ◽  
Vol 67 (3) ◽  
pp. 373-384 ◽  
Author(s):  
Jumah Masoud Mohammad Salmani ◽  
Xue Wu ◽  
Joe Antony Jacob ◽  
Rong Fu ◽  
Baoan Chen
Keyword(s):  
Standard Sample ◽  
Drug Distribution ◽  
Rat Plasma ◽  
Hplc Method ◽  
Standard Samples ◽  
Factors Affecting ◽  
Highly Hydrophobic ◽  
Plasma Compatibility

AbstractIn the current paper, an HPLC/UV method was developed and validated for determination of wogonin in plasma. Considerable attention was paid to the preparation of standard samples and factors affecting drug distribution. A preparation procedure was devised to simulate the conditions the drug is expected to experiencein vivowhile pointing to the shortcomings of previously published methods. The method was validated according to the FDA regulations and showed to be highly efficient and capable of extracting the drug and IS from the plasma accurately and precisely within the specified range of 50–500 ng mL−1. Further, the standard sample preparation of this method can be used as a guideline for other methods, particularly when highly hydrophobic drugs with considerable protein binding are involved and could be valuable in the field of bioanalysis to improve the reliability of methods.

Sign in / Sign up

Export Citation Format

Share Document