A descriptive epidemiological study on the treatment options for head and neck cancer: Transition before and after approval of cetuximab

2018 ◽  
Vol 28 (3) ◽  
pp. 330-336
Author(s):  
Shuhei Yamada ◽  
Izumi Sato ◽  
Koji Kawakami
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Epidemiological Study ◽  
Neck Cancer ◽  
Treatment Options ◽  
Before And After

NUTRITION ASSESSMENT IN HEAD AND NECK CANCER PATIENTS PRE and POST CHEMORADIOTHERAPY.

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Piyush Kumar ◽  
Bhavya P Pateneedi ◽  
Dharam P Singh ◽  
Arvind K Chauhan
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Nutritional Risk ◽  
Total Leukocyte Count ◽  
Risk Indicator ◽  
Anthropometric Parameters ◽  
Skin Fold Thickness ◽  
Before And After

INTRODUCTION: Head and neck cancer patients are frequently malnourished at the time of diagnosis and prior to the beginning of treatment. Deterioration of the nutritional status results in an increase in chemo radiotherapy related toxicity and this may increase the prolonged treatment time, which has been associated with poor clinical outcome. The present study aims to do nutritional assessment before and after chemo radiotherapy in head and neck cancer patients. MATERIAL AND METHODS: The present study was undertaken at the Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly. In this study, 50 patients of Head and neck tumours were enrolled and their nutrition was assessed before and after chemoradiotherapy. Nutrition assessment was done using different laboratory parameters like haemoglobin, total leukocyte count, blood urea, serum creatinine and serum bilirubin. Anthropometric parameters used are Body mass index, Skin fold thickness, and Mid-arm circumference. Nutritional risk indicator and PG-SGA score is measured before and after chemoradiotherapy. All the parameters were assessed and analysed using different statistical tests- Chi-square test, Fisher Exact test and paired t test.RESULTS: Haemoglobin decrease was statistically significant during treatment (p less than 0.001) and the decrease in total leukocyte count during treatment was showing trend towards significance (p value-0.056). There was deterioration in other parameters like blood urea, serum creatinine and serum bilirubin but was not statistically significant. Anthropometric parameters- Body mass index, mid-arm circumference and skin fold thickness and percent body fat showed a significant change (p less than 0.00001). Nutritional risk indicator and PG-SGA class has decreased for majority of patients during treatment, the change is statistically significant (p less than 0.00001 and p=0.0251) respectively.CONCLUSION: The nutrition has important role to play in the management of head and neck cancers by chemo radiotherapy. It helps to reduce the complications and improve the tolerance of chemo radiotherapy, thus avoiding treatment breaks which may lead to failure of treatment.

High rates of postoperative radiotherapy delay in head and neck cancer before and after Medicaid expansion

Head & Neck ◽  
2021 ◽  
Author(s):  
John Pang ◽  
Farhoud Faraji ◽  
Erik Risa ◽  
Loren K. Mell ◽  
Jeffrey J. Houlton ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Postoperative Radiotherapy ◽  
Medicaid Expansion ◽  
Before And After

scholarly journals Changes in carnitine levels through induction chemotherapy in head and neck cancer patients as a potential cause of therapy-related malaise

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tatsuya Ito ◽  
Kiyoaki Tsukahara ◽  
Hiroki Sato ◽  
Akira Shimizu ◽  
Isaku Okamoto
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Cancer Site ◽  
Primary Cancer ◽  
Analog Scale ◽  
Before And After ◽  
Primary Cancer Site ◽  
Total Carnitine

Abstract Background Carnitine is related to malaise, and cisplatin is associated with decreased carnitine. The purpose of this study was to elucidate the effects of one course of induction chemotherapy (IC) for head and neck cancer on blood carnitine levels, focusing on free carnitine (FC). Methods This single-center prospective study investigated 20 patients diagnosed with primary head and neck cancer who underwent IC with cisplatin, docetaxel, and 5-fluorouracil. FC, acylcarnitine (AC), and total carnitine (TC) levels were measured before starting therapy and on Days 7 and 21 after starting IC. In addition, malaise was evaluated before and after therapy using a visual analog scale (VAS). Results All subjects were men and the most common primary cancer site was the hypopharynx (9 patients). FC levels before starting therapy and on Days 7 and 21 were 47.7 ± 2.2 μM/mL, 56.7 ± 2.2 μM/mL, and 41.1 ± 1.9 μM/mL, respectively. Compared with the baseline before starting therapy, FC had significantly decreased on Day 21 (p = 0.007). AC levels before starting therapy and on Days 7 and 21 were 12.5 ± 1.2 μM/mL, 13.6 ± 1.4 μM/mL, and 10.7 ± 0.7 μM/mL, respectively. TC levels before starting therapy and on Days 7 and 21 were 60.2 ± 2.5 μM/mL, 70.2 ± 3.3 μM/mL, and 51.7 ± 2.3 μM/mL, respectively. No significant differences in AC, TC or VAS were seen before the start of therapy and on Day 21. Conclusions After IC, a latent decrease in FC occurred without any absolute deficiency or subjective malaise.

Distinct Imaging Modalities in Head and Neck Cancer: Benefits and Drawbacks

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2777-2784
Author(s):  
Dana Merin ◽  
Roshni P R
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Imaging Techniques ◽  
Precise Determination ◽  
Imaging Biomarkers ◽  
Selection Strategies ◽  
Positron Emission ◽  
Before And After ◽  
Oncological Imaging

This review mainly focuses on the distinct imaging techniques in for head and neck cancer (HNC), its altered techniques used in diagnosis and its applications. It also depicts the upcoming imaging methods present in the field of HNC causing areas. It explains precise determination regarding the degree and extends of neoplasm. We mainly look on to the MRI(Magnetic resonance imaging), PET(Positron emission tomography), CT (computed tomography)imaging biomarkers for the management of HNC. It plays an important role in the therapy selection strategies and also enhances the therapeutic ratio in the management of HNC. The role of imaging techniques become increasingly more crucial in the management process in locally progressed head and neck squamous cell carcinoma(HNSCC). In this structure, PET allows non-invasive assessment of a range of tumour biomarkers such as metabolism, hypoxia and proliferation. MRI techniques such as can characterize different tissues by probing into their microstructure, providing a novel methodology in oncological imaging. CT, MRI, and PET/CT are widely used to determine the presence and extent of the tumours before and after treatment. This review depicts a synopsis of the most recent imaging strategies and imaging recommendations for every one of the different strides along the clinical way of patients with head and neck malignant growth.

scholarly journals Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab

2018 ◽  
Vol 11 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Katjana S. Schwab ◽  
Glenn Kristiansen ◽  
Hans H. Schild ◽  
Stefanie E.A. Held ◽  
Annkristin Heine ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Treatment Options ◽  
Cell Cancer ◽  
Metastatic Malignant Melanoma ◽  
Programmed Death ◽  
The Us ◽  
Platinum Refractory

Treatment options for patients with platinum-refractory, recurrent, metastatic head and neck squamous cell carcinoma (HNSCC) are limited, and prognosis is poor. Nivolumab (Opdivo) has been approved by the US Food and Drug Administration (FDA) for the treatment of patients with recurrent or metastatic HNSCC who have disease progression on or after platinum-based therapy. Recently, in patients with metastatic malignant melanoma a significant improvement of outcome and response was achieved with the combination of ipilimumab (CTLA4 antibody) and the programmed death (PD)-1 inhibitor nivolumab compared with monotherapy. Based on these results, the combination of nivolumab and ipilimumab has been approved by the FDA for the treatment of patients with unresectable or metastatic melanoma. So far, there have been no data concerning the combination of nivolumab and ipilimumab in squamous cell head and neck cancer. We here present the case of a 46-year-old male with refractory squamous cell head and neck cancer, who was successfully treated with the PD-1 inhibitor nivolumab in combination with the anti-CTLA4 antibody ipilimumab.

QOL assessment in head and neck cancer patients undergoing neoadjuvant chemotherapy and its impact on overall survival.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17519-e17519
Author(s):  
Sachin Dhumal ◽  
Vijay Maruti Patil ◽  
Vanita Noronha ◽  
Amit Joshi ◽  
Atanu Bhattacharjee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Treatment Options ◽  
Life Assessment ◽  
The Mean

e17519 Background: NACT (neoadjuvant chemotherapy) is one of the treatment options in advanced head and neck cancer (H&N cancer); however there is limited quality of life data available in these patients. Methods: Between August 2013- April 2014, 90 technically unresectable H&N cancer patients who were underwent NACT at our centre were selected for this analysis. EORTC QLQ-C30 and HN35 version 3.0 was used for quality of life assessment at baseline and after 02 cycles of NACT. PFS and OS was estimated by Kaplan Meier method. The mean change in QOL at various domains was calculated with 95% CI. The relationship between change in QOL domain and OS was analysed. Results: The median age of the cohort was 45 years (Range 21-65 years). The predominant subsite was oral cavity, in 62 patients (68.9%).The median PFS and OS was 10.53 months (95%CI 8.1-13.0) and 20.8 months (95%CI 15.1-26.5). The mean scores for all domains of QOL are shown in table 1. Conclusions: NACT leads to improvement in QOL in patients treated with head and neck cancers and its has impact on OS.[Table: see text]

Arterial spin labeling to determine tumor viability in head and neck cancer before and after treatment

2013 ◽  
Vol 40 (4) ◽  
pp. 920-928 ◽  
Author(s):  
Noriyuki Fujima ◽  
Kohsuke Kudo ◽  
Daisuke Yoshida ◽  
Akihiro Homma ◽  
Tomohiro Sakashita ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Before And After ◽  
Tumor Viability

Novel Treatment Options in Head and Neck Cancer

2017 ◽  
Vol 40 (6) ◽  
pp. 342-346 ◽  
Author(s):  
Patrick J. Schuler ◽  
Simon Laban ◽  
Johannes Doescher ◽  
Lars Bullinger ◽  
Thomas K. Hoffmann
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Treatment Options ◽  
Novel Treatment
Sign in / Sign up

Export Citation Format

Share Document