Synthesis of well‐defined block copolymer composed of flexible amphiphilic poly(ethylene glycol) and hydrophobic liquid crystalline segments by living coordination polymerization of allene derivatives and its application to thin film with perpendicularly oriented cylindrical nanostructure

Koyuki Sakai ◽  
Hiroki Nishiyama ◽  
Shinsuke Inagi ◽  
Ikuyoshi Tomita ◽  
Yusuke Hibi ◽  
2018 ◽  
Vol 47 (3) ◽  
pp. 426-432 ◽  
Sivan Yogev ◽  
Ayelet Shabtay-Orbach ◽  
Abraham Nyska ◽  
Boaz Mizrahi

Thermoresponsive materials have the ability to respond to a small change in temperature—a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Fibroblast NIH 3T3 and HaCaT keratinocyte cells were used for the cytotoxicity testing and a mouse model for the in vivo evaluation. In vivo results generally showed similar trends as the results seen in vitro, with all tested materials presenting a satisfactory biocompatibility in vivo. pNIPAM, however, showed the highest toxicity both in vitro and in vivo, which was explained by the release of harmful monomers and impurities. More data focusing on the biocompatibility of novel thermoresponsive biomaterials will facilitate the use of existing and future medical devices.

2021 ◽  
Vol 873 ◽  
pp. 53-58
Yang Yi Chen ◽  
Min Pan ◽  
Shan Hong Hu ◽  
Qi Huan ◽  
Chu Yang Zhang

The surface wettability of thermo-responsive random poly (ethylene glycol methyl ether methacrylate-co-triethylene glycol methyl ether methacrylate), abbreviated as P(MEOMA-co-MEO3MA), was investigated in thin film. UV-Vis spectroscopy shows that the LCST of P(MEOMA-co-MEO3MA) with molar ratios of 0:20, 6:14 and 9:11 were 43°C, 32 oC and 25 oC, respectively. LCST shifts towards lower temperature when molar ratio of MEOMA increases. ATR-FTIR indicates that P(MEOMA-co-MEO3MA) thin film experienced a collapse when the temperature passes its LCST. The contact angle of the paraffin oil on the film decreases 15o when the temperature is above its LCST, which confirms the surface wettability can be controlled. Atomic force microscopy shows the surface of the swollen thin film becomes rougher when above it LCST.

2014 ◽  
Vol 38 (8) ◽  
pp. 3569-3578 ◽  
Xiao-Hui Dai ◽  
Zhi-Ming Wang ◽  
Lu-You Gao ◽  
Jian-Ming Pan ◽  
Xiao-Hong Wang ◽  

pH-induced block copolymer SPPLA-b-PEG with porphyrin core for photodynamic therapy.

2016 ◽  
Vol 49 (10) ◽  
pp. 3789-3798 ◽  
Chengqiang Gao ◽  
Heng Zhou ◽  
Yaqing Qu ◽  
Wei Wang ◽  
Habib Khan ◽  

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