Unorthodox long-term aerosolized ampicillin use for methicillin-susceptible Staphylococcus aureus lung infection in a cystic fibrosis patient

2009 ◽  
Vol 44 (5) ◽  
pp. 512-515 ◽  
Author(s):  
Luis Máiz ◽  
Adelaida Lamas ◽  
Ana Fernández-Olmos ◽  
Lucrecia Suárez ◽  
Rafael Cantón
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Cystic Fibrosis Patient ◽  
Lung Infection

scholarly journals Transcriptional adaptations during long-term persistence of Staphylococcus aureus in the airways of a cystic fibrosis patient

2015 ◽  
Vol 305 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Nadine Windmüller ◽  
Anika Witten ◽  
Desirée Block ◽  
Boyke Bunk ◽  
Cathrin Spröer ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Cystic Fibrosis Patient

scholarly journals Chronic Staphylococcus aureus lung infection correlates with proteogenomic and metabolic adaptations leading to an increased intracellular persistence

2018 ◽  
Author(s):  
Xin Tan ◽  
Mathieu Coureuil ◽  
Elodie Ramond ◽  
Daniel Euphrasie ◽  
Marion Dupuis ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Molecular Mechanisms ◽  
Expression Profiles ◽  
Lung Infection ◽  
Genetic Modifications ◽  
Protein Expression Profiles ◽  
First Time ◽  
Chronic Lung Infection

AbstractBackgroundChronic lung infection of cystic fibrosis (CF) patients by Staphylococcus aureus is a well-established epidemiological fact. Indeed, S. aureus is the most commonly identified pathogen in the lungs of CF patients. Strikingly the molecular mechanisms underlying S. aureus persistency are not understood.MethodsWe selected pairs of sequential S. aureus isolates from 3 patients with CF and from one patient with non-CF chronic lung disease. We used a combination of genomic, proteomic and metabolomic approaches with functional assays for in-depth characterization of S. aureus long-term persistence.ResultsFor the first time, we show that late S. aureus isolates from CF patients have an increased ability for intracellular survival in CFBE-F508del cells compared to ancestral early isolates. Importantly, the increased ability to persist intracellularly was confirmed for S. aureus isolates within the own patient F508del epithelial cells. An increased ability to form biofilm was also demonstrated.Furthermore, we identified the underlying genetic modifications inducing altered protein expression profiles and notable metabolic changes. These modifications affect several metabolic pathways and virulence regulators that could constitute therapeutic targets.ConclusionsOur results strongly suggest that the intracellular environment might constitute an important niche of persistence and relapse necessitating adapted antibiotic treatments.SummaryS. aureus persists for years in the lungs of patients with cystic fibrosis despite antibiotic therapies. We demonstrate that S. aureus adaptation leads to increased intracellular persistence suggesting a key role for intracellular niche during S. aureus chronic lung infection.

Chronic Lung Infection Caused by Trichosporon mycotoxinivorans and Trichosporon mucoides in an Immunocompetent Cystic Fibrosis Patient

2016 ◽  
Vol 52 (7) ◽  
pp. 400 ◽  
Author(s):  
Francisco de Borja Martínez Muñiz ◽  
María Martínez Redondo ◽  
Concepción Prados Sánchez ◽  
Julio García Rodríguez
Keyword(s):  
Cystic Fibrosis ◽  
Cystic Fibrosis Patient ◽  
Lung Infection ◽  
Chronic Lung Infection

Proteus mirabilis as a cause of recurrent lung infection in a cystic fibrosis patient

1990 ◽  
Vol 9 (3) ◽  
pp. 234-235 ◽  
Author(s):  
M. Ojeda-Vargas ◽  
A. Pacheco ◽  
M. Elia ◽  
R. Villaverde ◽  
F. Baquero
Keyword(s):  
Cystic Fibrosis ◽  
Cystic Fibrosis Patient ◽  
Proteus Mirabilis ◽  
Lung Infection

scholarly journals Rapid Emergence of Resistance to Linezolid and Mutator Phenotypes in Staphylococcus aureus Isolates from an Adult Cystic Fibrosis Patient

2013 ◽  
Vol 57 (10) ◽  
pp. 5186-5188 ◽  
Author(s):  
Asmaa Tazi ◽  
Jeanne Chapron ◽  
Gerald Touak ◽  
Magalie Longo ◽  
Dominique Hubert ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Cystic Fibrosis Patient ◽  
Therapeutic Option ◽  
Clinical Isolates ◽  
23S Rrna ◽  
Mutator Phenotype ◽  
Content Type ◽  
Emergence Of Resistance ◽  
Rapid Emergence

ABSTRACTLinezolid has emerged as an important therapeutic option for the treatment ofStaphylococcus aureusin patients with cystic fibrosis. We report the rapid emergence, upon treatment with linezolid, of linezolid-resistantS. aureusclinical isolates through the accumulation of resistance-associated 23S rRNA mutations, together with acquisition of an altered mutator phenotype.

scholarly journals Impact of long-term airway Staphylococcus aureus (SA) colonisation in children with cystic fibrosis (CF): strains evolution and clinical outcome correlations

2008 ◽  
Vol 7 ◽  
pp. S45
Author(s):  
D. Claeys ◽  
M.V. Guillot ◽  
C.C. El Hachem ◽  
N. Curcio ◽  
C. Paris ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Clinical Outcome

scholarly journals MRSA eradication of newly acquired lower respiratory tract infection in cystic fibrosis

2016 ◽  
Vol 2 (1) ◽  
pp. 00064-2015 ◽  
Author(s):  
Emilie Vallières ◽  
Jacqueline C. Rendall ◽  
John E. Moore ◽  
John McCaughan ◽  
Anne I. Hoeritzauer ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Lower Respiratory Tract ◽  
Outcome Data ◽  
Success Strategies ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Clinical Benefits ◽  
Topical Treatments

UK cystic fibrosis (CF) guidelines recommend eradication of methicillin-resistant Staphylococcus aureus (MRSA) when cultured from respiratory samples. As there is no clear consensus as to which eradication regimen is most effective, we determined the efficacy of eradication regimens used in our CF centre and long-term clinical outcome.All new MRSA positive sputum cultures (n=37) that occurred between 2000 and 2014 were reviewed. Eradication regimen characteristics and clinical, microbiological and long-term outcome data were collected.Rifampicin plus fusidic acid was the most frequently used regimen (24 (65%) out of 37 patients), with an overall success rate of 79% (19 out of 24 patients). Eradication failure was more likely in patients with an additional MRSA-positive peripheral screening swab (p=0.03) and was associated with worse survival (p=0.04).Our results demonstrate the feasibility and clinical benefits of MRSA eradication. As peripheral colonisation was associated with lower eradication success, strategies combining systemic and topical treatments should be considered to optimise outcomes in CF patients.

scholarly journals Cedecea davisae’s Role in a Polymicrobial Lung Infection in a Cystic Fibrosis Patient

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Thayer G. Ismaael ◽  
Eleana M. Zamora ◽  
Faisal A. Khasawneh
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Burkholderia Cepacia ◽  
Airway Disease ◽  
Lung Infection ◽  
Emerging Pathogen ◽  
The Family ◽  
Healthcare Associated ◽  
Airway Colonization

Chronic airway colonization and infection are the hallmark of cystic fibrosis (CF).Staphylococcus aureus, Pseudomonas aeruginosa, andBurkholderia cepaciaare well-documented bacterial culprits in this chronic suppurative airway disease. Advanced molecular diagnostics have uncovered a possible role of a larger group of microorganisms in CF.Cedeceais a member of the family Enterobacteriaceae and is an emerging pathogen. We present a case of a polymicrobial healthcare-associated pneumonia in a CF patient caused byCedecea davisae, among other bacteria.

Staphylococcus aureus in the airways of cystic fibrosis patients - A retrospective long-term study

2018 ◽  
Vol 308 (6) ◽  
pp. 631-639 ◽  
Author(s):  
Mathias Schwerdt ◽  
Claudia Neumann ◽  
Bianca Schwartbeck ◽  
Stefanie Kampmeier ◽  
Susann Herzog ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Term Study ◽  
Long Term Study

Maintenance Treatment With Inhaled Ampicillin in Patients With Cystic Fibrosis and Lung Infection Due to Methicillin-Sensitive Staphylococcus aureus

2012 ◽  
Vol 48 (10) ◽  
pp. 384 ◽  
Author(s):  
Luis Máiz ◽  
Rosa Del Campo ◽  
María Castro ◽  
Dayra Gutiérrez ◽  
Rosa Girón ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Maintenance Treatment ◽  
Lung Infection
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