Theoretical Prediction of Physicochemical Properties, Performances and Sensitivities of some New Derivatives of Dinitro Triazolyl Triazine

2010 ◽  
Vol 35 (5) ◽  
pp. 482-486 ◽  
Author(s):  
Mohammad Hossein Keshavarz ◽  
Karim Esmailpoor ◽  
Masoud Kavosh Tehrani
Keyword(s):  
Theoretical Prediction ◽  
Physicochemical Properties ◽  
Derivatives Of

Synthesis and Physicochemical Properties of Energetic 1,2,4,5‐Tetrazinyl Derivatives of 5‐Nitro‐2,4‐dihydro‐1,2,4‐triazol‐3‐one

2021 ◽  
Vol 6 (30) ◽  
pp. 7654-7662
Author(s):  
Gennady F. Rudakov ◽  
Ivan B. Kozlov ◽  
Nikolay V. Boev ◽  
Svetlana S. Zinchenko ◽  
Lyudmila Ya. Melnikova ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Derivatives Of

Chemical modification and Physicochemical properties of new derivatives 5-(thiophen-3-ilmethyl)-4-R1-1,2,4-triazole-3-thiol

2021 ◽  
pp. 4621-4629
Author(s):  
O.A. Bihdan ◽  
V.V. Parchenko
Keyword(s):  
Physicochemical Properties ◽  
High Reactivity ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Triazole Derivatives ◽  
Pharmaceutical Ingredients ◽  
Current Trends ◽  
Wide Range ◽  
Derivatives Of

Current trends in the search for new biologically active compounds among synthetic molecules have arguably proved a priority in studies of the heterocyclic 1,2,4-triazole system. For many years, 1,2,4-triazole derivatives remain the object of close attention of scientists of various scientific fields. The unique properties of 1,2,4-triazole derivatives include high reactivity, which allows different modification of this system, practical absence of toxicity of these derivatives and the presence of a wide range of biological, pharmacological properties, which in the complex provides the prerequisites for the creation of new biologically active compounds, and in the future, active pharmaceutical ingredients (AFI). The aim of our work is to investigate some transformations in a number of derivatives of 5-(thiophen-3-ylmethyl) -4-R1-1,2,4-triazole-3-thiol, to study the physicochemical properties of the new synthesized compounds. A well-known fact remains the successful attempt of many scientists involved in the study of the heterocyclic 1,2,4-triazole system to synthesize potential biologically active compounds. The process of creating new molecules is very painstaking and requires considerable effort. The chemical approaches for the synthesis of the starting compounds required for further transformations are well known and described. Therefore, we used the corresponding N-R1-2 as intermediates for the synthesis of new 5-(thiophen-3-ylmethyl) -4-R1-1,2,4-triazole-3-thiols appropriate ones were used N-R1-2-(2-(thiophen-3-yl) acetyl) hydrazinocarbothioamide.

Synthesis and Physicochemical Properties of New Fluorescent Derivatives of Cytosine.

ChemInform ◽  
2006 ◽  
Vol 37 (30) ◽  
Author(s):  
Dorota Prukala
Keyword(s):  
Physicochemical Properties ◽  
Derivatives Of ◽  
Fluorescent Derivatives

scholarly journals The synthesis and physicochemical properties of new derivatives of 5-r-phenylamino-2-mercapto-1,3,4-thiadiazole

2016 ◽  
Vol 0 (1(85)) ◽  
pp. 24-28
Author(s):  
I. V. Sych ◽  
L. O. Perekhoda ◽  
Z. G. Ieromina ◽  
L. O. Grinevich ◽  
N. P. Kobzar ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Derivatives Of

Preparation and physicochemical properties of glycosylated derivatives of pea legumin

1990 ◽  
Vol 38 (8) ◽  
pp. 1700-1706 ◽  
Author(s):  
Daniele Caer ◽  
Alain Baniel ◽  
Muriel Subirade ◽  
Jacques Gueguen ◽  
Bernard Colas
Keyword(s):  
Physicochemical Properties ◽  
Derivatives Of

scholarly journals SYNTHESIS AND PHYSICOCHEMICAL PROPERTIES OF N-ACYL DERIVATIVES OF S-(2-METHYLQUINOLINE-4-YL)-L-CYSTEINE

2021 ◽  
Author(s):  
Luydmyla OMELYANCHIK ◽  
Oleksandr BRAZHKO ◽  
Viktoriia GENCHEVA ◽  
Iryna LABENSKA ◽  
Yuliіa PETRUSHA
Keyword(s):  
Physicochemical Properties ◽  
Derivatives Of ◽  
Acyl Derivatives

scholarly journals Synthesis, physicochemical properties and antigypoxic activity of some S-derivatives of 4-alkyl-5-(((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol

2020 ◽  
pp. 56-64
Author(s):  
E. O. Karpun ◽  
V. V. Parchenko
Keyword(s):  
Physicochemical Properties ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Acute Hypoxia ◽  
Spectral Parameters ◽  
Reference Drug ◽  
Mass Spectral ◽  
Biological Studies ◽  
Pharmacological Screening ◽  
Derivatives Of

Hypoxia is a discrepancy between the required energy of the cell in the mitochondrial oxidative phosphorylation system. The immediate cause of the deficiency is a decrease in the oxygen concentration in the mitochondria. Today there is a huge demand for the development of new anti-hypoxic drugs. t is known that 1,2,4-triazole compounds can have antimicrobial, anti-inflammatory, anti-hypoxic effects. Modification of the 1,2,4-triazole nucleus is a productive way to create original active molecules with a non-planar structure, for their binding to bio-target substrates. Derivatives of bis-1,2,4-triazoles may become potential compounds with anti-hypoxic action. The aim of our work was to synthesize new S-derivatives of 4-alkyl-5-(((3-(pyridine-4-yl)-1Н-1,2,4-triazole-5-yl)thio)methyl)-4Н-1,2,4-triazole-3-thiols, to investigate their physicochemical parameters using modern complex physicochemical research methods and to conduct primary pharmacological screening for anti-hypoxic activity in models of acute hypoxia with hypertension. The object of the study was the S-derivatives of 4-alkyl-5-(((3-(pyridine-4-yl)-1Н-1,2,4-triazole-5-yl)thio)methyl)-4Н-1,2,4-triazole-3-thiols. The structure of the synthesized compounds was confirmed by elemental analysis (CHNS), 1H NMR, the individuality of the molecules was proved by chromatographic mass spectral analysis. 1H NMR signals for substances are consistent with the proposed structure. The study of the anti-hypoxic activity of the got compounds of the series of S-substituted bis-1,2,4-triazoles was carried out on models of acute hypoxia with hypertension, where Mexidol (5%) 200 mg/kg as a reference drug. New S-derivatives of 4-methyl-5-(((3-(pyridine-4-yl)-1Н-1,2,4-triazole-5-yl)thio)methyl)-4Н-1,2,4-triazole-3-thiols (I a) and 4-ethyl-5-(((3-(pyridine-4-yl)-1Н-1,2,4-triazole-5-yl)thio)methyl)-4Н-1,2,4-triazole-3-thiols (I b) with acyl-aryl, acyl-alkyl and alkyl substituents. We studied their spectral parameters, physicochemical properties in the conditions of GC/MS, elemental analysis, 1H NMR spectroscopy. According to the results of biological studies on the anti-hypoxic effect, it was found that 1-((4-ethyl-5-(((3-(pyridine-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-yl)thio)propane-2-one is a compound that exceeds the anti-hypoxic activity of Mexidol and increases the lifespan of rats by 1.0% relative to the reference drug.

Sign in / Sign up

Export Citation Format

Share Document