scholarly journals Study of psychological state of cancer patients undergoing radiation therapy during novel coronavirus outbreak and effects of nursing intervention

2020 ◽  
Vol 9 (2) ◽  
pp. 83-89
Author(s):  
Shuchang Lou ◽  
Dejing Xu ◽  
Xiaodong Li ◽  
Yan Huan ◽  
Jun Li
Author(s):  
O. O. Kyrylova ◽  
V. P. Starenkiy ◽  
S. V. Artiukh ◽  
N. E. Prokhach ◽  
T. H. Kiian

Background. Being diagnosed with cancer is a dramatically stressful condition for a human. Radiation therapy (RT), which is an essential of combination antineoplastic treatment, can cause physical and emotional state changes. Realizing these changes is an additional stress factor that results in impaired life quality of a cancer patient as well refusal to undergo further treatment. At present, there is no distinct system of providing psychological aid for cancer patients in Ukraine. Purpose. To carry out analysis and generalization of research literature data in terms of providing psychological aid for cancer patients at RT stage and to present own findings of psychological study enrolling 55 female patients diagnosed with endometrial cancer at RT stage at SO «Grigoriev Institute for Medical Radiology and Oncology» within the period from 2015 to 2018. Materials and methods. The literature review involved available contributions obtained via literature search in domestic (Vernadsky National Library of Ukraine) and foreign databases (Scopus, Web of Science Core Collection, PubMed, BMC, ScienceDirect, Wiley Online Library, RNB). Fifty-five patients with endometrial cancer of stage I–II (T1b-c N0 M0 – T2a -b N0 M0) underwent clinical and laboratory examination. The diagnosis of adenocarcinoma was confirmed by means of a histologic study. All patients underwent panhysterectomy and postsurgery course of distant gamma-therapy on “РОКУС-АМ” device by split fractionation. Fifteen patients were provided with psychological correction at RT stage. In order to assess life quality, SF-36 (Health Status Survey) was used. An assessment of the severity of psychosomatic disorders in patients with endometrial cancer was made by means of EORTC QLQ-C30 survey. Results. The paper analyzes psychological aid provided to oncology patients at radiation therapy stage in Ukraine and overseas. It presents the peculiarities of patients’ psychological responses during irradiation and possible consequences of higher mental function impairment. The targets of psychological correction and factors influencing life quality of a patient have been considered as well as the effectiveness of psychotherapeutic interventions outcomes of different approaches has been provided. The study states that, currently, medical and psychological follow-up of cancer patients does not consist only in reassuring talk and drug correcting of their psychological state aimed to reduce distress, anxiety and depression level, but also in psychocorrection, psychoeducation, the access to psychotherapeutic groups, individual psychotherapy. The efficiency of applying own developed schemes of medical and psychological correction of emotional state of women with EC is presented, the use of which has made it possible to reduce the manifestations of sleep disorders, cognitive function and fatigue. Conclusions. Following a differentiated strategy when choosing methods of psychological aid for oncology patients and their families at radiation therapy stage via psychocorrection of emotional, cognitive and behavioral spheres, psychoeducation or psychotherapeutic interventions will make it possible to significantly improve their psychological status and quality of life.


2021 ◽  
Vol 12 ◽  
Author(s):  
Valerio Nardone ◽  
Alfonso Reginelli ◽  
Claudia Vinciguerra ◽  
Pierpaolo Correale ◽  
Maria Grazia Calvanese ◽  
...  

Introduction: Novel coronavirus (COVID-19) is having a devastating psychological impact on patients, especially patients with cancer. This work aims to evaluate mood disorders of cancer patients undergoing radiation therapy during COVID-19 in comparison with cancer patients who underwent radiation therapy in 2019.Materials and Methods: We included all the patients undergoing radiation therapy at our department in two-time points (once a week for a month in May 2019) and during the COVID-19 outbreak (in April 2020). All the patients were asked to fulfill a validated questionnaire (STAI-Y1, State trait anxiety inventory scale), the Symptom Distress thermometer (SDT) (from 0 to 10 score), and the Beck Depression Inventory v.2 (BDI-2). We took into account the COVID-19 outbreak and also sex, age, week of radiation treatment, and disease.Results: We included 458 patients (220 males and 238 females), with a median age of 64 years. STAI-Y1 median score was 40 (mean 41,3, range 19–79), whereas the median score of SDT was five and BDI-2 median score was 11. STAI-Y1, SDT, and BDI-2 were significantly correlated with the COVID-19 outbreak (p < 0,001 for all the tests), sex (p: 0,016 for STAI-Y1, p < 0.001 for SDT, p:0.013 for BDI-2), week of treatment (p: 0.012 for STAI-Y1 and p: 0.031 for SDT), and disease (p:0.015 for STAI-Y1, p < 0.001 for SDT and p:0.020 for BDI-2).Conclusions: The prevalence of mood disorders in patients undergoing radiation therapy is higher than expected and even higher during the COVID-19 outbreak. These measurements could be useful as a baseline to start medical humanities programs to decrease these scores.


Aging Health ◽  
2006 ◽  
Vol 2 (6) ◽  
pp. 919-930 ◽  
Author(s):  
Ajay Sandhu ◽  
Arno J Mundt

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.


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