scholarly journals Influence of circular permutations on the structure and stability of a six‐fold circular symmetric designer protein

2020 ◽  
Vol 29 (12) ◽  
pp. 2375-2386
Author(s):  
Bram Mylemans ◽  
Hiroki Noguchi ◽  
Els Deridder ◽  
Eveline Lescrinier ◽  
Jeremy R. H. Tame ◽  
...  
Keyword(s):  
Structure And Stability ◽  
Circular Permutations

Polyplex: A Promising Gene Delivery System

2019 ◽  
Vol 12 (6) ◽  
pp. 4681-4686
Author(s):  
Rohan Aggarwal ◽  
Monika Targhotra ◽  
Bhumika Kumar ◽  
P.K Sahoo ◽  
Meenakshi K Chauhan
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Viral Vectors ◽  
Gene Delivery System ◽  
Cationic Polymers ◽  
Therapeutic Application ◽  
Promising Alternative ◽  
Structure And Stability ◽  
The Past

In the past few years gene delivery system has gained a huge attention owing to its proved efficacy in several diseases especially in those caused by genetic and/oroncological malfunctioning. The effective gene delivery mainly depends on the carrier molecules that can ensure the safe and specific delivery of the nucleic acidmolecules. Viral vectors have been used for a longer period as the gene transfer vehicle. However, these viral vectors have potential immunological disadvantages that made them less preferred. Recently, non-viral vectors such as polyplexes have emerged as a promising alternative for viral vectors. Polyplexes are formed by conjugating a polymer with DNA and in maximum cases the cationic polymers are preferred over others. The structure and stability of the polyplexes depends on various factors. The ability of the polymer to condense the DNA mainly dictates the efficiency of the polyplex mediated transfection. In this review we are going to provide a framework for the synthesis and design of the polyplexes along with the structure and stability of the complexes pertaining to mechanism of action, characterization and therapeutic application, including polyethyleneimine mediated cytotoxicity as well as newer strategies for the generation of better polyplexes.

Changes in the capsid structure and stability of defective particles of bacteriophage R17.

1977 ◽  
Vol 24 (2) ◽  
pp. 590-601
Author(s):  
W J Iglewski
Keyword(s):  
Structure And Stability

scholarly journals The structure and stability of human plasma cold-insoluble globulin.

1979 ◽  
Vol 254 (5) ◽  
pp. 1501-1505 ◽  
Author(s):  
S.S. Alexander ◽  
G. Colonna ◽  
H. Edelhoch
Keyword(s):  
Human Plasma ◽  
Structure And Stability ◽  
Cold Insoluble Globulin

scholarly journals 1H-NMR studies of the structure and stability of the bovine pancreatic secretory trypsin inhibitor.

1982 ◽  
Vol 257 (14) ◽  
pp. 8337-8342
Author(s):  
A De Marco ◽  
E Menegatti ◽  
M Guarneri
Keyword(s):  
1H Nmr ◽  
Trypsin Inhibitor ◽  
Pancreatic Secretory Trypsin Inhibitor ◽  
Nmr Studies ◽  
Structure And Stability

Theoretical assessment of the structure and stability of the λ phase of nitrogen

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Watit Sontising ◽  
Gregory J. O. Beran
Keyword(s):  
Structure And Stability ◽  
Theoretical Assessment
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