Principal component analysis of chemical shift perturbation data of a multiple-ligand-binding system for elucidation of respective binding mechanism

2012 ◽  
Vol 81 (1) ◽  
pp. 107-118 ◽  
Author(s):  
Tsuyoshi Konuma ◽  
Young-Ho Lee ◽  
Yuji Goto ◽  
Kazumasa Sakurai
Keyword(s):  
Principal Component Analysis ◽  
Chemical Shift ◽  
Ligand Binding ◽  
Principal Component ◽  
Component Analysis ◽  
Chemical Shift Perturbation ◽  
Binding Mechanism ◽  
Binding System ◽  
Perturbation Data ◽  
Multiple Ligand

scholarly journals Studying the collective motions of the adenosine A2A receptor as a result of ligand binding using principal component analysis

2019 ◽  
Vol 37 (18) ◽  
pp. 4685-4700 ◽  
Author(s):  
Marlet Martínez-Archundia ◽  
José Correa-Basurto ◽  
Sarita Montaño ◽  
Jorge L. Rosas-Trigueros
Keyword(s):  
Principal Component Analysis ◽  
Ligand Binding ◽  
Principal Component ◽  
Component Analysis ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Collective Motions ◽  
Adenosine A2a

scholarly journals Multiple Ligand-Bound States of a Phosphohexomutase Revealed by Principal Component Analysis of NMR Peak Shifts

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jia Xu ◽  
Akella V. S. Sarma ◽  
Yirui Wei ◽  
Lesa J. Beamer ◽  
Steven R. Van Doren
Keyword(s):  
Principal Component Analysis ◽  
Bound States ◽  
Principal Component ◽  
Component Analysis ◽  
Multiple Ligand

scholarly journals Principal Component Analysis of Glutamate Receptor Ligand Binding Domains

2014 ◽  
Vol 106 (2) ◽  
pp. 805a
Author(s):  
John Belcher ◽  
Yongneng Yao ◽  
Anthony J. Berger ◽  
Mark L. Mayer ◽  
Albert Lau
Keyword(s):  
Principal Component Analysis ◽  
Ligand Binding ◽  
Glutamate Receptor ◽  
Principal Component ◽  
Component Analysis ◽  
Receptor Ligand ◽  
Binding Domains

A German version of the Intermittent Claudication Questionnaire (ICQ): cultural adaptation and validation

VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 333-342 ◽  
Author(s):  
Kirchberger ◽  
Finger ◽  
Müller-Bühl
Keyword(s):  
Principal Component Analysis ◽  
Intermittent Claudication ◽  
Completion Time ◽  
Short Form ◽  
Principal Component ◽  
Component Analysis ◽  
German Version ◽  
Average Completion Time ◽  
Sf 36 ◽  
Related Quality

Background: The Intermittent Claudication Questionnaire (ICQ) is a short questionnaire for the assessment of health-related quality of life (HRQOL) in patients with intermittent claudication (IC). The objective of this study was to translate the ICQ into German and to investigate the psychometric properties of the German ICQ version in patients with IC. Patients and methods: The original English version was translated using a forward-backward method. The resulting German version was reviewed by the author of the original version and an experienced clinician. Finally, it was tested for clarity with 5 German patients with IC. A sample of 81 patients were administered the German ICQ. The sample consisted of 58.0 % male patients with a median age of 71 years and a median IC duration of 36 months. Test of feasibility included completeness of questionnaires, completion time, and ratings of clarity, length and relevance. Reliability was assessed through a retest in 13 patients at 14 days, and analysis of Cronbach’s alpha for internal consistency. Construct validity was investigated using principal component analysis. Concurrent validity was assessed by correlating the ICQ scores with the Short Form 36 Health Survey (SF-36) as well as clinical measures. Results: The ICQ was completely filled in by 73 subjects (90.1 %) with an average completion time of 6.3 minutes. Cronbach’s alpha coefficient reached 0.75. Intra-class correlation for test-retest reliability was r = 0.88. Principal component analysis resulted in a 3 factor solution. The first factor explained 51.5 of the total variation and all items had loadings of at least 0.65 on it. The ICQ was significantly associated with the SF-36 and treadmill-walking distances whereas no association was found for resting ABPI. Conclusions: The German version of the ICQ demonstrated good feasibility, satisfactory reliability and good validity. Responsiveness should be investigated in further validation studies.

Review of Three-Mode Principal Component Analysis: Theory and Applications, Vol. 2.

1984 ◽  
Vol 29 (11) ◽  
pp. 915-916
Author(s):  
William R Koch
Keyword(s):  
Principal Component Analysis ◽  
Principal Component ◽  
Component Analysis ◽  
Analysis Theory
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