scholarly journals Synthesis and pharmacological characterization of ethylenediamine synthetic opioids in human μ‐opiate receptor 1 (OPRM1) expressing cells

2019 ◽  
Vol 7 (5) ◽  
Author(s):  
Tom Hsu ◽  
Jayapal R. Mallareddy ◽  
Kayla Yoshida ◽  
Vincent Bustamante ◽  
Tim Lee ◽  
...  
Keyword(s):  
Opiate Receptor ◽  
Pharmacological Characterization ◽  
Synthetic Opioids ◽  
Μ Opiate Receptor

scholarly journals Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

2018 ◽  
Vol 134 ◽  
pp. 101-107 ◽  
Author(s):  
Michael H. Baumann ◽  
Susruta Majumdar ◽  
Valerie Le Rouzic ◽  
Amanda Hunkele ◽  
Rajendra Uprety ◽  
...  
Keyword(s):  
Recreational Drug ◽  
Pharmacological Characterization ◽  
Synthetic Opioids ◽  
Novel Synthetic Opioids

scholarly journals Opioids depress breathing through two small brainstem sites

2019 ◽  
Author(s):  
Iris Bachmutsky ◽  
Xin Paul Wei ◽  
Eszter Kish ◽  
Kevin Yackle
Keyword(s):  
Respiratory Depression ◽  
Cell Types ◽  
Opiate Receptor ◽  
The United States ◽  
Opioid Overdose ◽  
Brain Areas ◽  
Brain Site ◽  
Innovative Solutions ◽  
Μ Opiate Receptor

AbstractThe rates of opioid overdose in the United States quadrupled between 1999 and 2017, reaching a staggering 130 deaths per day. This health epidemic demands innovative solutions that require uncovering the key brain areas and cell types mediating the cause of overdose—opioid respiratory depression. Here, we identify two primary changes to breathing after administering opioids. These changes implicate the brainstem’s breathing circuitry which we confirm by locally eliminating the μ-Opiate receptor. We find the critical brain site is the origin of the breathing rhythm, the preBötzinger Complex, and use genetic tools to reveal that just 70-140 neurons in this region are responsible for its sensitivity to opioids. Future characterization of these neurons may lead to novel therapies that prevent respiratory depression while sparing analgesia.

Characterization of μ-Opiate Receptor in Human Epidermis and Keratinocytes

2006 ◽  
Vol 885 (1) ◽  
pp. 368-371 ◽  
Author(s):  
M. BIGLIARDI-QI ◽  
P. L. BIGLIARDI ◽  
S. BÜCHNER ◽  
T. RUFLI
Keyword(s):  
Opiate Receptor ◽  
Human Epidermis ◽  
Μ Opiate Receptor

Discovery and pharmacological characterization of a selective delta opiate receptor antagonist (CP-646,777)

MedChemComm ◽  
2011 ◽  
Vol 2 (5) ◽  
pp. 413 ◽  
Author(s):  
Spiros Liras ◽  
Stanton F. McHardy ◽  
Martin P. Allen ◽  
Barb E. Segelstein ◽  
Steven D. Heck ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Opiate Receptor ◽  
Pharmacological Characterization

Pharmacological characterization of Tibouchina granulosa

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
CC Guilhon ◽  
A Minho ◽  
AS Barros ◽  
PD Fernandes
Keyword(s):  
Pharmacological Characterization

Molecular and Pharmacological Characterization of Hamster HCA1 and HCA2

2016 ◽  
Vol 16 (1) ◽  
pp. 61-69
Author(s):  
Chester Kuei ◽  
Grace Lee ◽  
Victory Joseph ◽  
Jing Qian ◽  
Jingwen Yang ◽  
...  
Keyword(s):  
Pharmacological Characterization

Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for antiepilepsy

2019 ◽  
Vol 33 (8) ◽  
pp. 9154-9166 ◽  
Author(s):  
Fan Zhang ◽  
Yani Liu ◽  
Feng Tang ◽  
Bo Liang ◽  
Huanming Chen ◽  
...  
Keyword(s):  
Pharmacological Characterization ◽  
Channel Opener

scholarly journals Biological and Pharmacological Characterization of Ascorbic Acid and Nicotinamide Chitosan Nanoparticles against Insulin-Resistance-Induced Cognitive Defects: A Comparative Study

ACS Omega ◽  
2021 ◽  
Vol 6 (5) ◽  
pp. 3587-3601
Author(s):  
Hend Abd-Allah ◽  
Maha Nasr ◽  
Omar A. H. Ahmed-Farid ◽  
Salma A. El-Marasy ◽  
Rofanda M. Bakeer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Ascorbic Acid ◽  
Comparative Study ◽  
Chitosan Nanoparticles ◽  
Pharmacological Characterization ◽  
Cognitive Defects
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