Synthesis and herbicidal activity of novel pyrazole aromatic ketone analogs as HPPD inhibitor

2019 ◽  
Vol 76 (3) ◽  
pp. 868-879 ◽  
Author(s):  
Qing Fu ◽  
Peng‐Peng Cai ◽  
Long Cheng ◽  
Liang‐Kun Zhong ◽  
Cheng‐Xia Tan ◽  
...  
Keyword(s):  
Herbicidal Activity ◽  
Aromatic Ketone

Influence of Absolute Configuration of Indanofan on Herbicidal Activity

2001 ◽  
Vol 26 (4) ◽  
pp. 383-384 ◽  
Author(s):  
Akemi HOSOKAWA ◽  
Osamu IKEDA ◽  
Chizuko SASAKI ◽  
Yasuko T. OSANO ◽  
Tetsuo JIKIHARA
Keyword(s):  
Absolute Configuration ◽  
Herbicidal Activity

Chemical structure and herbicidal activity of .ALPHA.,.ALPHA.-dialkylbenzyl containing thiolcarbamate compounds.

1989 ◽  
Vol 34 (1) ◽  
pp. 27-36
Author(s):  
Kaoru IKEDA ◽  
Kiyoshi SUGAYA
Keyword(s):  
Chemical Structure ◽  
Herbicidal Activity

Toxicity, Uptake, and Distribution of Simazine in Canna hybrida `King Humbert': Implications for Phytoremediation

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 484e-485
Author(s):  
Patrick C. Wilson ◽  
Ted Whitwell ◽  
Steven J. Klaine
Keyword(s):  
Mass Production ◽  
Photosynthetic Efficiency ◽  
Liquid Scintillation ◽  
Herbicidal Activity ◽  
Fresh Mass ◽  
Contaminated Water ◽  
Golf Courses ◽  
Plant Tolerance ◽  
Nutrient Media ◽  
Potential Use

This research focuses on the potential use of Canna hybrida `King Humbert' for removing simazine from contaminated water generated at golf courses and ornamental nurseries. Because of simazine's herbicidal activity, it is important for levels in solution not to exceed plant tolerance levels. Tolerance levels for C. hybrida were determined by dosing plants for 7 d with 0, 0.01, 0.03, 0.1, 0.3, 1.0, or 3.0 mg simazine/L nutrient media. Measurements of 7-d fresh mass production and photosynthetic efficiency (Fv/Fm) were taken. Simazine uptake and distribution within the plant was determined by dosing plants with 2.03 mCi 14C-simazine (0.243 mg/L) for 1, 3, 5, or 7 d. Plant tissues were analyzed by combustion and liquid scintillation counting. Fresh mass production was reduced 66% and 78% for plants exposed to 1.0 and 3.0 mg/L, respectively. Likewise, photosynthetic efficiency was reduced to 66% and 40% of the controls at the same respective concentrations. Plant uptake of simazine accounted for 13%, 34%, 48%, and 65% of the original simazine in the dosing solution after 1-, 3-, 5-, and 7-d exposure, respectively. This simazine was distributed primarily between roots and leaves.

A Facile One-pot Synthesis of Substituted Quinolines via Cascade Friedlander Reaction from Isoxazoles with Ammonium Formate-Pd/C and Ketones

2020 ◽  
Vol 17 (3) ◽  
pp. 211-215
Author(s):  
Da Chen ◽  
Xuan Wang ◽  
Runnan Wang ◽  
Yao Zhan ◽  
Xiaohan Peng ◽  
...  
Keyword(s):  
Hydrogen Transfer ◽  
Ammonium Formate ◽  
Aromatic Ketone ◽  
Reaction Conditions ◽  
One Pot ◽  
Diverse Range ◽  
Strong Base ◽  
Aromatic Ketones ◽  
Substituted Quinolines ◽  
New Strategy

The Friedlander reaction is the most commonly used method to synthesis substituted quinolines, the essential intermediates in the medicine industry. A facile one-pot approach for synthesizing substituted quinolines by the reaction of isoxazoles, ammonium formate-Pd/C, concentrated sulfuric acid, methanol and ketones using Friedlander reaction conditions is reported. Procedures for the synthesis of quinoline derivatives were optimized, and the yield was up to 90.4%. The yield of aromatic ketones bearing electron-withdrawing groups was better than the ones with electron-donating substituents. The structures of eight substituted quinolines were characterized by MS, IR, H-NMR and 13CNMR, which were in agreement with the expected structures. The mechanism for the conversion was proposed, which involved the Pd/C catalytic hydrogen transfer reduction of unsaturated five-membered ring of isoxazole to produce ortho-amino aromatic ketones. Then the nucleophilic addition of with carbonyl of the ketones generated Schiff base in situ, which underwent an intermolecular aldol reaction followed by the elimination of H2O to give production of substituted quinolines. This new strategy can be readily applied for the construction of quinolines utilizing a diverse range of ketones and avoids the post-reaction separation of the o-amino aromatic ketone compounds. The conventionally used o-amino aromatic ketone compounds in Friedlander reaction to prepare substituted quinoline are laborious to synthesize and are apt to self-polymerize. While oxazole adopted in this work can be prepared at ease by the condensation of benzoacetonitrile and nitrobenzene derivatives under the catalysis of a strong base. Moreover, the key features of this protocol are readily available starting materials, excellent functional group tolerance, mild reaction conditions, operational simplicity, and feasibility for scaling up.

Preliminary Screening of Isolated Mycoherbicidal Fungi for the Management of Noxious Weed Xanthiumstrumarium

2019 ◽  
Vol 6 (02) ◽  
Author(s):  
AJAY KUMAR SINGH ◽  
AKHILESH KUMAR PANDEY
Keyword(s):  
Culture Filtrate ◽  
Photosynthetic Pigment ◽  
Phytopathogenic Fungi ◽  
Herbicidal Activity ◽  
Preliminary Screening ◽  
Detached Leaf ◽  
Noxious Weed ◽  
Complete Collapse

Natural phytotoxins of fungi are great source for the discovery of new herbicide and its offer a benign and eco-friendly alternative to manage weed. Thus, this study aimed to select potential fungi with potent herbicidal activity for control ofweeds. In the present study, various phytopathogenic fungi were isolated from infected tissues of various weeds and evaluated againstXanthium strumarium, a problematic monocotyledonous weed of open lands, agriculture, horticulture and forests. Herbicidal potential of Cell Free Culture Filtrate (CFCF) of strains ofPhoma herbarum (FGCCW#18, FGCCW#43) Fusariummonilifromecoded as FGCCW#35 and Fusarium roseum coded as FGCCW#55againstXanthium strumariumwere evaluated by seedling and shoot cut bioassays. Maximum mortalities of shoots, seedlings and phytotoxic damage were obtainedfrom28 day sold cell free culture filtrate (CFCF) of FGCCW#18 at 100% concentration. Significant reduction in biological contents i.e. photosynthetic pigment and protein was observed in the host weed on treatment with the CFCF as determined by detached leaf bioassay. Phytotoxic damage such as severe wilting, chlorosis, necrosis and complete collapse of the entire parts of the weed were also noticed due to CFCF application.

scholarly journals Discovery, characterization and functional improvement of kumamonamide as a novel plant growth inhibitor that disturbs plant microtubules

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takashi Ishida ◽  
Haruna Yoshimura ◽  
Masatsugu Takekawa ◽  
Takumi Higaki ◽  
Takashi Ideue ◽  
...  
Keyword(s):  
Plant Growth ◽  
Human Life ◽  
Growth Inhibitor ◽  
Herbicidal Activity ◽  
Functional Improvement ◽  
Microtubule Inhibitors ◽  
Plant Microtubules ◽  
Plant Growth Inhibitor ◽  
Derivatives Of ◽  
Synthetic Intermediate

AbstractThe discovery and useful application of natural products can help improve human life. Chemicals that inhibit plant growth are broadly utilized as herbicides to control weeds. As various types of herbicides are required, the identification of compounds with novel modes of action is desirable. In the present study, we discovered a novelN-alkoxypyrrole compound, kumamonamide fromStreptomyces werraensisMK493-CF1 and established a total synthesis procedure. Resulted in the bioactivity assays, we found that kumamonamic acid, a synthetic intermediate of kumamonamide, is a potential plant growth inhibitor. Further, we developed various derivatives of kumamonamic acid, including a kumamonamic acid nonyloxy derivative (KAND), which displayed high herbicidal activity without adverse effects on HeLa cell growth. We also detected that kumamonamic acid derivatives disturb plant microtubules; and additionally, that KAND affected actin filaments and induced cell death. These multifaceted effects differ from those of known microtubule inhibitors, suggesting a novel mode of action of kumamonamic acid, which represents an important lead for the development of new herbicides.

Synthesis, herbicidal activity study and molecular docking of novel pyrimidine thiourea

2020 ◽  
pp. 104766
Author(s):  
Jia-hui Li ◽  
Yan Wang ◽  
Yun-peng Wu ◽  
Ran-hong Li ◽  
Shuang Liang ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Herbicidal Activity

Synthesis, Crystal Structure, Herbicidal Activity, and SAR Study of Novel N-(Arylmethoxy)-2-chloronicotinamides Derived from Nicotinic Acid

2021 ◽  
Author(s):  
Chen-Sheng Yu ◽  
Qiao Wang ◽  
Joanna Bajsa-Hirschel ◽  
Charles L. Cantrell ◽  
Stephen O. Duke ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Nicotinic Acid ◽  
Herbicidal Activity ◽  
Sar Study

ChemInform Abstract: SYNTHESIS AND HERBICIDAL ACTIVITY OF FLUORINATED N-PHENYLALKANESULFONAMIDES

1975 ◽  
Vol 6 (17) ◽  
pp. no-no
Author(s):  
R. D. TREPKA ◽  
J. K. HARRINGTON ◽  
J. W. MCCONVILLE ◽  
K. T. MCGURRAN ◽  
A. MENDEL ◽  
...  
Keyword(s):  
Herbicidal Activity

Herbicidal activity of the antibiotics geldanamycin and nigericin

1990 ◽  
Vol 9 (1-4) ◽  
pp. 19-25 ◽  
Author(s):  
Rod M. Heisey ◽  
Alan R. Putnam
Keyword(s):  
Herbicidal Activity
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