Effect of aqueous-ethanol extract from Crocus sativus (saffron) on guinea-pig isolated heart

2007 ◽  
Vol 22 (3) ◽  
pp. 330-334 ◽  
Author(s):  
M. H. Boskabady ◽  
M. N. Shafei ◽  
A. Shakiba ◽  
H. Sang Sefidi
Keyword(s):  
Guinea Pig ◽  
Aqueous Ethanol ◽  
Isolated Heart ◽  
Ethanol Extract ◽  
Crocus Sativus

TIRYAQ-I-AFAYEE (A POLYHERBAL FORMULATION) OF UNANI MEDICINE USED IN THE PREVENTION OF WABĀI AMRĀD (EPIDEMIC/ PANDEMIC DISEASES) – AN APPRAISAL

2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Athar Parvez Ansari ◽  
Mohammad Arif ◽  
Abdul Raheem ◽  
Arsheed Iqbal ◽  
Firdaus Kausar
Keyword(s):  
Influenza A ◽  
Aloe Vera ◽  
Ethanol Extract ◽  
Crocus Sativus ◽  
Antimicrobial Effects ◽  
Unani Medicine ◽  
Polyherbal Formulation ◽  
Saffron Extract ◽  
Published Research ◽  
Epidemic Diseases

BACKGROUND AND OBJECTIVE: Tiryaq-i-Afayee, a polyherbal formulation of Unani medicine used in the prevention and treatment of various wabāi amrād (epidemic/ pandemic diseases) since olden days. This review study has been carried out to explore the therapeutic efficacy of this formulation in the light of scientific studies. MATERIALS & METHODS: A total of 74 literature comprising classical Unani texts from the period of 9th – 20th century AD, and published research articles in various reputed journals from 1999 – 2020 AD were reviewed regarding immunomodulatory, antiviral, antiinfluenza, antioxidant, antitussive, antimicrobial effects of Tiryaq-iAfayee, as a whole preparation and its individual ingredients. RESULTS:Tiryaq-i-Afayee contains Sibr Zard (Aloe vera) (2 parts), Murr Makki (Commiphora myrrha) (1 part) and Zafran (Crocus sativus) (1 part). It is prepared in the form of pill, and 2 g is used in alternate day for prevention and management of epidemic diseases. All the three ingredients of this compound formulation belong to plants and individually used for various medicinal purposes. DISCUSSION: A study revealed that Tiryaq-i-Afayee possesses significant immunomodulatory effect in a small group of immuno compromised persons. An ethanol extract of Aloe vera exhibited antiinfluenza effect against influenza A virus due to presence of aloe-emodine (anthraquinone glycoside). Certain studies have reported that Commiphora myrrha possesses significant antioxidant and antimicrobial effects against Staphylococcus aureus and Pseudomonas aeruginosa. Another study has revealed that Saffron extract exhibited promising antiviral activity due to presence of crocin and picrocrocin. CONCLUSION: The aforementioned classical and modern conventional materials have given plentiful information regarding use of Tiryaq-i-Afayee in the prevention of epidemic/ pandemic diseases.

scholarly journals Hydroxyl radicals’ production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart

2013 ◽  
Vol 32 (02) ◽  
pp. 221-228 ◽  
Author(s):  
Hana Paulova ◽  
Tibor Stracina ◽  
Jiri Jarkovsky ◽  
Marie Novakova ◽  
Eva Taborska
Keyword(s):  
Guinea Pig ◽  
Hydroxyl Radicals ◽  
Isolated Heart ◽  
Ischemia And Reperfusion

The effects of Zn2+ on guinea pig isolated heart preparations

1993 ◽  
Vol 38 (3) ◽  
pp. 289-299 ◽  
Author(s):  
Vicky P. Kalfakakou ◽  
Angelos M. Evangelou ◽  
Jacques Benveniste ◽  
Bernard Arnoux
Keyword(s):  
Guinea Pig ◽  
Isolated Heart

Phytoconstituents from Curcuma longa L. aqueous ethanol extract and its immunomodulatory effect on diabetic infected rats

2015 ◽  
Vol 14 (1) ◽  
pp. 36
Author(s):  
ManalH Shabana ◽  
EmanM Shahy ◽  
MonaM Taha ◽  
GehanM Mahdy ◽  
MahaH Mahmoud
Keyword(s):  
Aqueous Ethanol ◽  
Curcuma Longa ◽  
Ethanol Extract ◽  
Immunomodulatory Effect

scholarly journals Safety and efficacy of a dried aqueous ethanol extract of Melissa officinalis L. leaves when used as a sensory additive for all animal species

EFSA Journal ◽  
2020 ◽  
Vol 18 (2) ◽  
Author(s):  
◽  
Vasileios Bampidis ◽  
Giovanna Azimonti ◽  
Maria de Lourdes Bastos ◽  
Henrik Christensen ◽  
...  
Keyword(s):  
Animal Species ◽  
Aqueous Ethanol ◽  
Ethanol Extract ◽  
Melissa Officinalis ◽  
Safety And Efficacy

scholarly journals Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

2019 ◽  
Vol 139 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Petr Vesely ◽  
Tibor Stracina ◽  
Miroslava Hlavacova ◽  
Josef Halamek ◽  
Jana Kolarova ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Isolated Heart ◽  
Rr Intervals

scholarly journals INHIBITORY EFFECT OF ETHANOLIC EXTRACT OF ERIOBOTRYA JAPONICA LEAVES PRE-INCUBATED WITH THEOPHYLLINE AND ASPIRIN ON ISOLATED GUINEA PIG TRACHEAL

2018 ◽  
Vol 11 (13) ◽  
pp. 46
Author(s):  
Marianne Marianne ◽  
Urip Harahap ◽  
Emil Salim ◽  
Dadang Irfan Husori ◽  
Fahrumsyah Jali Rambe ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Protective Effect ◽  
Contractile Response ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Eriobotrya Japonica ◽  
Relaxant Effect ◽  
Significant Difference

 Objectives: The objectives of the study were to examine the inhibitory effect of ethanol extract of Eriobotrya japonica leaves (EEEJL) pre-incubated with theophylline and aspirin on isolated guinea pig tracheal chains against acetylcholine (ACh)-induced contraction.Methods: The effect of EEEJL (1-8 mg/Ml) on the isolated tracheal strips was tested in vitro. Furthermore, the mechanism of relaxant effects of EEEJL was evaluated in the presence of theophylline and aspirin.Results: The contractile response evoked by Ach (1.25 × 10−3 M) was decreased by EEEJL (effective concentration50 = 1.36 mg/mL) and has no significant difference of relaxant effect to that of EEEJL pre-incubated with theophylline and aspirin (p>0.05).Conclusion: The EEEJL decreased the ACh-induced contraction through the inhibition of PDE and the protective effect on prostaglandin E2.

Reduced glutathione modulates the arachidonic acid induced coronary reactions

1984 ◽  
Vol 62 (10) ◽  
pp. 1261-1267 ◽  
Author(s):  
Jaime Talesnik ◽  
James N. Tsoporis
Keyword(s):  
Arachidonic Acid ◽  
Guinea Pig ◽  
Reduced Glutathione ◽  
Isolated Heart ◽  
Prostaglandin E ◽  
Guinea Pig Heart ◽  
Rat Hearts ◽  
Resistance Vessels ◽  
Vasodilator Action ◽  
Perfused Hearts

Coronary flow was recorded from spontaneously beating isolated perfused hearts of rats and guinea pigs. Arachidonic acid (AA), in single bolus doses, produced a fast short lasting coronary constriction followed by a slow developing but persisting vasodilation. These reactions (biphasic type) were characteristic of the guinea pig heart. In about 50% of the rat hearts the vasoconstrictor action predominated while the biphasic response was obtained in the rest of the experiments. Pretreatment of rats with aspirin prevented the responses to AA in the isolated heart. The administration of reduced glutathione (GSH) (about 1 mM to the rat or 0.5–0.75 mM to the guinea pig hearts) produced a marked development and (or) enhancement of the vasodilator action of AA. Repeated or single large doses of AA produced a change of pattern of responses from biphasic to constrictor type; the addition of GSH restored the vasodilator phase. Since GSH directs the endoperoxide metabolism towards the synthesis of prostaglandin E2 (PGE2), we postulate that the coronary dilatation of resistance vessels produced by AA would be due to a great extent to PGE2.

The chronotropic action of neurotensin in the guinea pig isolated heart

Peptides ◽  
1985 ◽  
Vol 6 (5) ◽  
pp. 841-845 ◽  
Author(s):  
Hélène Bachelard ◽  
Serge St-Pierre ◽  
Francis Rioux
Keyword(s):  
Guinea Pig ◽  
Isolated Heart ◽  
Chronotropic Action
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