The morphofunctional state of regional lymph nodes of white mongrel rats after endolymphatic introduction of gold nanoparticles with a diameter from 5 nm to 30 nm was studied. Endolymphatic introduction of gold nanoparticles was shown to have a direct immunomodulatory effect even at small sizes of nanogold. Morphological rearrangements in the regional lymph nodes testify to the activation of migration, proliferation and differentiation of immunocompetent cells, which suggests the immunomodulatory effect of gold nanoparticles.
Key words: endolymphatic injection of gold nanoparticles, inguinal lymph nodes, cell populations.