Protection by ginseng saponins against cyclophosphamide‐induced liver injuries in rats by induction of cytochrome P450 expression and mediation of the l ‐arginine/nitric oxide pathway based on metabolomics

2021 ◽  
Author(s):  
Jianbo Chen ◽  
Zhiman Li ◽  
Mei Hua ◽  
Yinshi Sun
Keyword(s):  
Nitric Oxide ◽  
Cytochrome P450 ◽  
Liver Injuries ◽  
P450 Expression ◽  
Nitric Oxide Pathway

L-Arginine/Nitric Oxide Pathway and Interaction with Lead Acetate on Rat Submandibular Gland Function

2000 ◽  
Vol 87 (5) ◽  
pp. 198-203 ◽  
Author(s):  
Mohammad Abdollahi ◽  
Ahmadreza Dehpour ◽  
Fatemeh Shafayee
Keyword(s):  
Nitric Oxide ◽  
Submandibular Gland ◽  
Lead Acetate ◽  
Gland Function ◽  
Rat Submandibular Gland ◽  
Nitric Oxide Pathway

A gene expression study of the glutamate-nitric oxide pathway in schizophrenia

2018 ◽  
Author(s):  
Makoto Kinoshita ◽  
Florian Freudenberg ◽  
Esin Candemir ◽  
Sarah Kittel-Schneider
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Gene Expression Study ◽  
Expression Study ◽  
Nitric Oxide Pathway

Effects of Inhibition of the l -Arginine/Nitric Oxide Pathway on Vasodilation Caused by β-Adrenergic Agonists in Human Forearm

Circulation ◽  
1997 ◽  
Vol 95 (9) ◽  
pp. 2293-2297 ◽  
Author(s):  
Matthew Dawes ◽  
Philip J. Chowienczyk ◽  
James M. Ritter
Keyword(s):  
Nitric Oxide ◽  
Adrenergic Agonists ◽  
Human Forearm ◽  
Nitric Oxide Pathway

scholarly journals Quercetin relaxes human gastric smooth muscles directly through ATP‐sensitive potassium channels and not depending on the nitric oxide pathway

2021 ◽  
Author(s):  
Beata Modzelewska ◽  
Krzysztof Drygalski ◽  
Tomasz Kleszczewski ◽  
Andrzej Chomentowski ◽  
Krzysztof Koryciński ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Potassium Channels ◽  
Smooth Muscles ◽  
Nitric Oxide Pathway

scholarly journals The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms

2021 ◽  
Vol 22 (16) ◽  
pp. 8447
Author(s):  
Przemysław J. Danek ◽  
Wojciech Kuban ◽  
Władysława A. Daniel
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Combined Treatment ◽  
Pharmacological Therapy ◽  
Mental Wellbeing ◽  
Cyp Enzymes ◽  
P450 Expression ◽  
Male Wistar Rats ◽  
Expression And Activity

In order to achieve a desired therapeutic effect in schizophrenia patients and to maintain their mental wellbeing, pharmacological therapy needs to be continued for a long time, usually from the onset of symptoms and for the rest of the patients’ lives. The aim of our present research is to find out the in vivo effect of chronic treatment with atypical neuroleptic iloperidone on the expression and activity of cytochrome P450 (CYP) in rat liver. Male Wistar rats received a once-daily intraperitoneal injection of iloperidone (1 mg/kg) for a period of two weeks. Twenty-four hours after the last dose, livers were excised to study cytochrome P450 expression (mRNA and protein) and activity, pituitaries were isolated to determine growth hormone-releasing hormone (GHRH), and blood was collected for measuring serum concentrations of hormones and interleukin. The results showed a broad spectrum of changes in the expression and activity of liver CYP enzymes, which are important for drug metabolism (CYP1A, CYP2B, CYP2C, and CYP3A) and xenobiotic toxicity (CYP2E1). Iloperidone decreased the expression and activity of CYP1A2, CP2B1/2, CYP2C11, and CYP3A1/2 enzymes but increased that of CYP2E1. The CYP2C6 enzyme remained unchanged. At the same time, the level of GHRH, GH, and corticosterone decreased while that of T3 increased, with no changes in IL-2 and IL-6. The presented results indicate neuroendocrine regulation of the investigated CYP enzymes during chronic iloperidone treatment and suggest a possibility of pharmacokinetic/metabolic interactions produced by the neuroleptic during prolonged combined treatment with drugs that are substrates of iloperidone-affected CYP enzymes.

scholarly journals Cytochrome P450 expression and regulation in the brain

2020 ◽  
pp. 1-29
Author(s):  
Wojciech Kuban ◽  
Władysława Anna Daniel
Keyword(s):  
Cytochrome P450 ◽  
P450 Expression ◽  
The Brain
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