Dissociative attachment studies by negative-ion time-of-flight mass spectrometry

1995 ◽  
Vol 9 (4) ◽  
pp. 336-343 ◽  
Author(s):  
E. Krishnakumar ◽  
K. Nagesha
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
Negative Ion ◽  
Dissociative Attachment ◽  
Flight Mass Spectrometry

Chemical profiling of Dioscorea septemloba by High Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry

2020 ◽  
Vol 58 (8) ◽  
pp. 709-717
Author(s):  
Yun Ling ◽  
Lu Chen ◽  
Dan Wang ◽  
Xin Xiao ◽  
Wenjing Xu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Electrospray Ionization ◽  
High Performance ◽  
Time Of Flight ◽  
Negative Ion ◽  
Chemical Compositions ◽  
Flight Mass Spectrometry ◽  
Promising Source

Abstract The rhizomes of Dioscorea septemloba (DS) is one of traditional Chinese medicine, which can be used for treatments of urethral and renal infections, as well as rheumatism. Nevertheless, detailed information on DS chemical compositions is still scarce. Therefore, the present work is aimed at investigating the phytochemical components of DS using high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry in negative ion mode. The proposed method provided tentative identification of 32 components, 6 of which were determined to be new. The present study highlighted the importance of DS as a promising source of medicinal ingredients and provides valuable information on the new potential components in DS.

Comparative Analysis of the Chemical Consistency Between the Traditional and Mixed Decoction of Maimendong Decoction by Ultra-Performance Liquid Chromatography Coupled to Quadrupole with Time-of-Flight Mass Spectrometry (UPLC–QTOF-MS)-Based Chemical Profiling Approach

2020 ◽  
Vol 58 (6) ◽  
pp. 549-561 ◽  
Author(s):  
Lan Yang ◽  
Zhenhua Zhu ◽  
Zhonghua Qi ◽  
Xinsheng Fan ◽  
Dawei Qian ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Time Of Flight ◽  
Ultra Performance Liquid Chromatography ◽  
Negative Ion ◽  
Chemical Profiling ◽  
Flight Mass Spectrometry ◽  
Traditional Preparation ◽  
Ginsenoside Rg5 ◽  
Negative Ion Mode

Abstract Take Maimendong Decoction (MMDD), one of the Chinese classic herbal formulas, as an object to evaluate the chemical consistency between traditional decoction and mixed decoction. The ultra-performance liquid chromatography coupled to quadrupole with time-of-flight mass spectrometry-based chemical profiling approach has been utilized. A total of 48 major peaks are detected from these two decoctions under the present chromatographic and mass spectrometry conditions. The results of negative ion mode show nine significant inconsistencies. Liquiritin, ginsenoside Ro and ginsenoside Rg5/Rk1 are detected with higher intensity in traditional preparation sample than the mixed decoction, while licoisoflavone A is higher in mixed decoction samples than the traditional one. The mechanisms involved in the chemical changes were assumed to be anti-inflammation, anti-oxidative stress and so on, suggesting these two different preparation approaches of MMDD may lead to a possibility of discrepant clinical outcomes.

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