P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes 1 1Abbreviations: FTI, farnesyl-protein transferase inhibitor; FTase, farnesyl-protein transferase; and LC-MS, liquid chromatography-mass spectrometry.

Inhibitory Potency ◽

Farnesyl Protein Transferase ◽

Binding Spectra

Study of in vitro metabolism of m-nisoldipine in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography–mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2014.03.030 ◽

2014 ◽

Vol 97 ◽

pp. 65-71 ◽

Cited By ~ 20

Author(s):

Lin Yuan ◽

Peipei Jia ◽

Yupeng Sun ◽

Chengcheng Zhao ◽

Xuran Zhi ◽

...

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Cytochrome P450 Enzymes

In vitro metabolism of BYZX in human liver microsomes and the structural elucidation of metabolite by liquid chromatography–mass spectrometry method

Journal of Chromatography B ◽

10.1016/j.jchromb.2007.07.029 ◽

2007 ◽

Vol 857 (2) ◽

pp. 266-274 ◽

Cited By ~ 11

Author(s):

Zong-ling Xia ◽

Jing-yan Ying ◽

Rong Sheng ◽

Su Zeng ◽

Yong-zhou Hu ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Spectrometry Method ◽

Mass Spectrometry Method

Methanol adducts leading to the identification of a reactive aldehyde metabolite of CPAQOP in human liver microsomes by ultra-high-performance liquid chromatography/mass spectrometry

10.1002/rcm.7772 ◽

2016 ◽

Vol 31 (1) ◽

pp. 145-151 ◽

Cited By ~ 1

Author(s):

Scott Martin ◽

Eva M. Lenz ◽

Robin Smith ◽

David G. Temesi ◽

Alexandra L. Orton ◽

...

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Human Liver ◽

High Performance ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Chromatography Mass Spectrometry ◽

Reactive Aldehyde

Progress in quantitative methods based on liquid chromatography-mass spectrometry for drug metabolizing enzymes in human liver microsomes

Chinese Journal of Chromatography ◽

10.3724/sp.j.1123.2015.03023 ◽

2015 ◽

Vol 33 (6) ◽

pp. 553

Author(s):

Huanhuan WANG ◽

Yayao LÜ ◽

Bo PENG ◽

Xiaohong QIAN ◽

Yangjun ZHANG

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Quantitative Methods ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes ◽

Chromatography Mass Spectrometry

Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry

10.1002/rcm.1891 ◽

2005 ◽

Vol 19 (8) ◽

pp. 1069-1074 ◽

Cited By ~ 10

Author(s):

E. Kantharaj ◽

Peter B. Ehmer ◽

An Tuytelaars ◽

Anne Van Vlaslaer ◽

Claire Mackie ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Simultaneous Measurement ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Metabolite Identification ◽

Human Liver Microsomes ◽

Metabolic Stability ◽

Ion Trap Mass Spectrometry

Study of the in vitro metabolic profile of a new α2-adrenergic agonist in rat and human liver microsomes by using liquid chromatography-multiple-stage mass spectrometry and nuclear magnetic resonance

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2019.03.067 ◽

2019 ◽

Vol 172 ◽

pp. 67-77

Author(s):

Josiane de O. Cardoso ◽

Bianca F. da Silva ◽

Tiago Venâncio ◽

Marina G. da Rocha Pitta ◽

Ivan da R. Pitta ◽

...

Keyword(s):

Mass Spectrometry ◽

Nuclear Magnetic Resonance ◽

Liquid Chromatography ◽

Magnetic Resonance ◽

Human Liver ◽

Metabolic Profile ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Adrenergic Agonist

Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 5′-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography–Tandem Mass Spectrometry

Drug Metabolism and Disposition ◽

10.1124/dmd.114.063016 ◽

2015 ◽

Vol 43 (7) ◽

pp. 1137-1146 ◽

Cited By ~ 15

Author(s):

Boram Lee ◽

Hyeon-Kyeong Ji ◽

Taeho Lee ◽

Kwang-Hyeon Liu

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry

10.1002/rcm.3220 ◽

2007 ◽

Vol 21 (20) ◽

pp. 3317-3322 ◽

Cited By ~ 16

Author(s):

Hai-Zhi Bu ◽

Ping Zhao ◽

Deepak K. Dalvie ◽

William F. Pool

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

Comparative metabolism of tussilagone in rat and human liver microsomes using ultra-high-performance liquid chromatography coupled with high-resolution LTQ-Orbitrap mass spectrometry

10.1002/rcm.7262 ◽

2015 ◽

Vol 29 (18) ◽

pp. 1641-1650 ◽

Cited By ~ 7

Author(s):

Xin-Shi Zhang ◽

Wei Ren ◽

Bao-Lin Bian ◽

Hai-Yu Zhao ◽

Shu Wang

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Resolution ◽

Human Liver ◽

High Performance ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Comparative Metabolism ◽

Orbitrap Mass Spectrometry

In vitro metabolism of corydaline in human liver microsomes and hepatocytes using liquid chromatography-ion trap mass spectrometry

Journal of Separation Science ◽

10.1002/jssc.201101094 ◽

2012 ◽

Vol 35 (9) ◽

pp. 1102-1109 ◽

Cited By ~ 9

Author(s):

Hye Young Ji ◽

Hyeri Lee ◽

Jeong-Han Kim ◽

Ki Hyun Kim ◽

Kang Ro Lee ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Human Liver ◽

Ion Trap ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Ion Trap Mass Spectrometry