Researches on sulphanilamide, para-amino-benzoic acid and their derivatives. IV: The behaviour of sulphanilamide, p-aminobenzoic acid and of their derivatives with respect to the mercury/solution interface (polarographic investigations) and to lecithin an

Abstract Polyphenol oxidase enzyme, performing browning reactions in fruits and vegetables, was purificated from damson plum (Prunus insititia) which has a high antioxidant activity. Firstly, partially purified polyphenol oxidase was treated by 0-80% ammonium sulfate precipitation and dialysis, respectively. Characterization studies were carried out by using catechol, 4-methyl catechol, pyrogallol and caffeic acid as 0.05M/ pH:7.2/ 25°C; 0.2M/ pH:4.5/ 10°C; 0.01M/ pH:6.8/ 5°C and 0.2M/ pH:8.5/ 10°C, respectively. The kinetic constants of Vmax and KM were calculated for the same substrates as 17219.97 U/(mL*min) and 11.67mM; 7309.72 U/(mL*min) and 5mM; 12580.12 U/(mL*min) and 3.74mM; 12100.41 U/(mL*min) and 6.25 mM, respectively. Catechol gave the highest Vmax value when compared to others. In the second step, purification was performed by using Sepharose 4B-L-Tyrosine-p-amino benzoic acid and Sepharose 6B-L-Tyrosine-p-amino benzoic acid affinity gels. A single band of approximately as 50-55 kDa was observed in SDS-PAGE and Native-PAGE. 90 and 10.2 purification folds were obtained for Prunus insititia PPO by the reference Sepharose-4B-L-Tyrosine-p-aminobenzoic acid and original Sepharose-6B-L-Tyrosine-p-aminobenzoic acid gels, respectively. PPO enzyme purification from Prunus insititia by affinity chromatography has not been investigated in literature yet.

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Spectroscopic Studies of Some Drugs of Toxicological Interest. Part II. p-Aminobenzoic Acid Drugs

Applied Spectroscopy ◽

10.1366/000370269774380842 ◽

1969 ◽

Vol 23 (3) ◽

pp. 254-256 ◽

Cited By ~ 1

Author(s):

A. Mustafa ◽

R. Abu-Eittah ◽

S. Elgendi

Keyword(s):

Charge Transfer ◽

Benzoic Acid ◽

Absorption Spectra ◽

Electronic Absorption ◽

Intramolecular Charge Transfer ◽

Electronic Absorption Spectra ◽

Spectroscopic Studies ◽

Aminobenzoic Acid ◽

Long Wavelength ◽

Amino Benzoic Acid

The electronic absorption spectra of some drugs derived from p-amino benzoic acid were studied. The effect of the substituent on the position of band maxima and intensity has been rationalized. Long wavelength energies have been found to agree well with calculated energies of the intramolecular charge transfer bands.

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Synthesis and antibacterial activity of some Schiff bases derived from 4-aminobenzoic acid

Journal of the Serbian Chemical Society ◽

10.2298/jsc0510155p ◽

2005 ◽

Vol 70 (10) ◽

pp. 1155-1162 ◽

Cited By ~ 70

Author(s):

Jigna Parekh ◽

Pranav Inamdhar ◽

Rathish Nair ◽

Shipra Baluja ◽

Sumitra Chanda

Keyword(s):

Molecular Structure ◽

Antibacterial Activity ◽

Benzoic Acid ◽

Schiff Bases ◽

Bacterial Strain ◽

Antibacterial Agents ◽

Aminobenzoic Acid ◽

Bacterial Strains ◽

E Coli ◽

Amino Benzoic Acid

The following Schiff bases have been synthesized: (1) 4-(2-chlorobenzylidene)amino benzoic acid JP1, (2) 4 (furan-2-ylmethylene)amino benzoic acid JP2, (3) 4-[(3-phenylallylidene)amino]benzoic acid JP3, (4) 4 (2-hydroxybenzylidene)amino benzoic acid JP4, (5) 4 (4-hydroxy-3-methoxybenzylidene)amino benzoic acid JP5 and (6) 4 (3-nitrobenzylidene)amino benzoic acid JP6. They were screened as potential antibacterial agents against a number of medically important bacterial strains. The antibacterial activity was studied against A. faecalis ATCC 8750, E. aerogenes ATCC 13048, E. coli ATCC 25922, K. pneumoniae NCIM 2719 S. aureus ATCC 25923, P. vulgaris NCIM 8313, P. aeruginosa ATCC 27853 and S. typhimurium ATCC 23564. The antibacterial activity was evaluated using the Agar Ditch method. The solvents used were 1,4-dioxane and dimethyl sulfoxide. Different effects of the compounds were found in the bacterial strains in vestigated and the solvents used, suggesting, once again, that the antibacterial activity is dependent on the molecular structure of the compound, the solvent used and the bacterial strain under consideration. In the present work, 1,4-dioxane proved to be a good solvent in inhibiting the above stated bacterial strains.

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