scholarly journals Parametric and non-parametric confidence intervals of the probability of identifying early disease stage given sensitivity to full disease and specificity with three ordinal diagnostic groups

2011 ◽  
Vol 30 (30) ◽  
pp. 3532-3545 ◽  
Author(s):  
Tuochuan Dong ◽  
Lili Tian ◽  
Alan Hutson ◽  
Chengjie Xiong
Keyword(s):  
Confidence Intervals ◽  
Disease Stage ◽  
Early Disease ◽  
Early Disease Stage ◽  
Non Parametric

Colchicine in Behçet Syndrome: A Longterm Survey of Patients in a Controlled Trial

2014 ◽  
Vol 41 (4) ◽  
pp. 735-738 ◽  
Author(s):  
Vedat Hamuryudan ◽  
Gulen Hatemi ◽  
Koray Tascilar ◽  
Sebahattin Yurdakul ◽  
Cem Mat ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Disease Stage ◽  
Early Disease ◽  
Double Blind ◽  
Behçet Syndrome ◽  
Behcet Syndrome ◽  
Cumulative Duration ◽  
Continuous Use ◽  
Early Disease Stage

Objective.To test the hypothesis that colchicine use during early disease decreases immunosuppressive use in Behçet syndrome (BS) in the long term.Methods.Patients with BS who participated in a double-blind, placebo-controlled trial of colchicine 16.6 ± 1.1 years ago were evaluated for immunosuppressive use during the posttrial period.Results.We could contact 90/116 patients; 28 (31%) received immunosuppressives during the posttrial period, 14 being from the colchicine arm. Posttrial colchicine use and cumulative duration were similar between patients who received immunosuppressives and those who did not.Conclusion.Continuous use of colchicine, even when initiated at an early disease stage, does not seem to decrease the use of immunosuppressives in the long term.

Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer’s Disease Transgenic Mouse Model at an Early Disease Stage

2020 ◽  
Vol 74 (1) ◽  
pp. 91-99 ◽  
Author(s):  
W.M.A.D. Binosha Fernando ◽  
Ian J. Martins ◽  
Michael Morici ◽  
Prashant Bharadwaj ◽  
Stephanie R. Rainey-Smith ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Sodium Butyrate ◽  
Memory Performance ◽  
Amyloid Β ◽  
Transgenic Mouse Model ◽  
Disease Stage ◽  
Early Disease ◽  
Cognitive Memory ◽  
Early Disease Stage

scholarly journals Borderline ovarian tumors

2006 ◽  
Vol 14 (1-2) ◽  
pp. 62-63
Author(s):  
Katarina Mastilovic ◽  
Tatjana Ivkovic-Kapicl ◽  
Milica Zivaljevic ◽  
Jelka Rajovic ◽  
Dejan Nincic
Keyword(s):  
Surgical Treatment ◽  
Malignant Tumors ◽  
Young Patients ◽  
Ovarian Tumors ◽  
Disease Stage ◽  
Early Disease ◽  
Oncogenic Potential ◽  
Stage Of Disease ◽  
Borderline Ovarian Tumors ◽  
Early Disease Stage

Borderline ovarian tumors are classified between benign cystadenoma and malignant cystadenocarcinoma. They are characterized as malignant tumors by histopathological features, which make them different from the benign ones. These tumors are commonly diagnosed at the early disease stage. The treatment of these tumors is surgical. The prognosis depends on the stage of disease and histopahtological types. We present 10 patients operated at the Institute of Oncology Sremska Kamenica because of malignant tumors with low malignant oncogenic potential in the period between 2000 and 2005. All patients had surgical treatment with ex tempore diagnostics, hysterectomy and adnexectomy with total omentectomy, or unilaterals adnexectomy. All patients had negative cytoanalytic findings of the small pelvis. Histopathological findings are necessary to confirm the diagnosis of disease. In young patients who had no children fertility can be preserved.

scholarly journals Atrichia with Papular Lesions: Importance of Histology at an Early Disease Stage

2017 ◽  
Vol 4 (3) ◽  
pp. 129-130 ◽  
Author(s):  
Vanessa B. Rocha ◽  
Nilceo Michalany ◽  
Neusa Y.S. Valente ◽  
Luciana B. Pereira ◽  
Aline Donati
Keyword(s):  
Disease Stage ◽  
Early Disease ◽  
Early Disease Stage

Fertility-preserving Management of Endometrial Carcinoma

2011 ◽  
Vol 07 (03) ◽  
pp. 191
Author(s):  
Luis M Chiva ◽  
Sonsoles Alonso ◽  
◽  
Keyword(s):  
Endometrial Cancer ◽  
Hormonal Treatment ◽  
Disease Stage ◽  
Low Grade ◽  
Reproductive Outcome ◽  
Early Disease ◽  
Gynaecological Malignancy ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Early Disease Stage

Endometrial cancer is the most common gynaecological malignancy, usually diagnosed in post-menopausal women. However, an incidence of 2–14 % of cases occurring in women <45 years of age has been reported. In this group of younger patients, because of the childbearing challenges, there is an increased percentage of nulliparity. Due to the early disease stage and the low grade of differentiation at the time of diagnosis, an improved prognosis has been reported in this group of patients. Many reports have described conservative treatment of this tumour in selected patients with the aim of preserving fertility. In this article, we review the literature for a better assessment of selection criteria, risk of concomitant neoplasias, hormonal treatment and clinical and reproductive outcome. We have concluded that fertility-preserving management of endometrial cancer is feasible in selected patients with an acceptable clinical and reproductive outcome.

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