Quantile regression and empirical likelihood for the analysis of longitudinal data with monotone missing responses due to dropout, with applications to quality of life measurements from clinical trials

2019 ◽  
Vol 38 (16) ◽  
pp. 2972-2991
Author(s):  
Yang Lv ◽  
Guoyou Qin ◽  
Zhongyi Zhu ◽  
Dongsheng Tu
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Longitudinal Data ◽  
Quantile Regression ◽  
Empirical Likelihood ◽  
Missing Responses ◽  
Quality Of Life Measurements

scholarly journals Role of “health-related quality of life” measurements in the design of drug clinical trials

2010 ◽  
Vol 34 (1) ◽  
pp. 16-22 ◽  
Author(s):  
R. San Miguel ◽  
V. del Villar ◽  
C. Pérez ◽  
M. de Frutos ◽  
J. Mar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Quality Of Life Measurements

scholarly journals Fe de errores de «Role of «health-reated quality of life» measurements in the design of drug clinical trials»

2011 ◽  
Vol 35 (2) ◽  
pp. 100
Author(s):  
R. San Miguel ◽  
V. del Villar ◽  
C. Pérez ◽  
M. de Frutos ◽  
J. Mar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Quality Of Life Measurements

Quality of life measurements in major depression

1996 ◽  
Vol 11 (3) ◽  
pp. 123-126 ◽  
Author(s):  
P Bech
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Major Depression ◽  
External Validity ◽  
Randomized Clinical Trials ◽  
Internal Validity ◽  
Efficacy And Safety ◽  
Quality Of Life Measurements

SummaryIn randomized clinical trials in patients with major depression quality of life is considered as an important dimension of treatment outcome in relation to clinical efficacy and safety. The internal validity, reliability, as well as external validity of quality of life scales have been analysed. It is concluded that such scales have their most appropriate applicability in medicine and long-term trials with antidepressants.

scholarly journals Percutaneous nephrostomy versus retrograde ureteral stenting for acute upper obstructive uropathy: a systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ismail Zul Khairul Azwadi ◽  
Mohd Noor Norhayati ◽  
Mohd Shafie Abdullah
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Obstructive Uropathy ◽  
Meta Analysis ◽  
Percutaneous Nephrostomy ◽  
Procedural Pain ◽  
Controlled Trials ◽  
Failure Rates ◽  
Ureteral Stenting

AbstractAcute obstructive uropathy is associated with significant morbidity among patients with any condition that leads to urinary tract obstruction. Immediate urinary diversion is necessary to prevent further damage to the kidneys. In many centres, the two main treatment options include percutaneous nephrostomy (PCN) and retrograde ureteral stenting (RUS). The purpose of this study if to compare the efficacy and safety of PCN and RUS for the treatment of acute obstructive uropathy. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, CINAHL, EMBASE, the World Health Organisation International Clinical Trials Registry Platform and ClinicalTrials.gov. We also searched the reference lists of included studies to identify any additional trials. We included randomised controlled trials and controlled clinical trials comparing the outcomes of clinical improvement (septic parameters), hospitalisation duration, quality of life, urinary-related symptoms, failure rates, post-procedural pain [measured using a visual analogue scale (VAS)] and analgesics use. We conducted statistical analyses using random effects models and expressed the results as risk ratio (RR) and risk difference (RD) for dichotomous outcomes and mean difference (MD) for continuous outcomes, with 95% confidence intervals (CIs). Seven trials were identified that included 667 patients. Meta-analysis of the data revealed no difference in the two methods in improvement of septic parameters, quality of life, failure rates, post-procedural pain (VAS), or analgesics use. Patients receiving PCN had lower rates of haematuria and dysuria post-operatively and longer hospitalisation duration than those receiving RUS. PCN and RUS are effective for the decompression of an obstructed urinary system, with no significant difference in most outcomes. However, PCN is preferable to RUS because of its reduced impact on the patient’s post-operative quality of life due to haematuria and dysuria, although it is associated with slightly longer hospitalisation duration.

Quality of life in asthma clinical trials: comparison of salmeterol and salbutamol.

1995 ◽  
Vol 151 (1) ◽  
pp. 66-70 ◽  
Author(s):  
E F Juniper ◽  
P R Johnston ◽  
C M Borkhoff ◽  
G H Guyatt ◽  
L P Boulet ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials
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