α‐Tocopherol‐Conjugated, Open Chain Sugar‐Mimicking Cationic Lipids: Design, Synthesis and In–Vitro Gene Transfection Properties

2021 ◽  
Vol 6 (46) ◽  
pp. 13025-13033
Author(s):  
Venkatesh Ravula ◽  
Venkanna Muripiti ◽  
Shireesha Manthurthi ◽  
Srilakshmi V. Patri
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids ◽  
Open Chain ◽  
Design Synthesis

Dramatic influence of the hydroxy functionality of azasugar moiety in the head group region of tocopherol-based cationic lipids on in vitro gene transfection efficacies

2021 ◽  
Author(s):  
Venkanna Muripiti ◽  
Brijesh Lohchania ◽  
Venkatesh Ravula ◽  
Shireesha Manturthi ◽  
Srujan Marepally ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids ◽  
Head Group ◽  
Nonviral Vectors

Cationic lipids have been effectively used as nonviral vectors for the delivery of polynucleic acids into the cytosol.

Design, synthesis and in vitro evaluation ofd-glucose-based cationic glycolipids for gene delivery

2016 ◽  
Vol 14 (5) ◽  
pp. 1611-1622 ◽  
Author(s):  
Chengxi He ◽  
Shang Wang ◽  
Meiyan Liu ◽  
Chunyan Zhao ◽  
Shuanglin Xiang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Gene Transfection ◽  
Design Synthesis ◽  
In Vitro Evaluation

Two novel series of cationic cyclic glycolipids were synthesized and the gene transfection efficiencies of these glycolipids were investigeted.

Design, Synthesis, Molecular Docking and Biological Evaluation of 1-(benzo[d]thiazol-2-ylamino)(phenyl)methyl)naphthalen-2-ol Derivatives as Antiproliferative Agents

2019 ◽  
Vol 16 (10) ◽  
pp. 837-845
Author(s):  
Sandhya Jonnala ◽  
Bhaskar Nameta ◽  
Murthy Chavali ◽  
Rajashaker Bantu ◽  
Pallavi Choudante ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Inhibitory Activity ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Mouse Skin ◽  
Coupling Reaction ◽  
Binding Mode ◽  
Biological Evaluation ◽  
Design Synthesis

A class of 1-((benzo[d]thiazol-2-ylamino)(phenyl)methyl)naphthalen-2-ol derivatives (4a-t) has been synthesized in good yields through a three component coupling reaction. The newly synthesized compounds were evaluated for their in vitro antiproliferative activity against five cell lines such as DU145 (human prostate cancer), MDA-MB-B231 (human breast cancer), SKOV3 (human ovarian cancer), B16-F10 (mouse skin melanoma) and CHO-K1 (Chinese hamster ovary cells), a noncancerous cell line. In vitro inhibitory activity indicates that compounds 4a, 4b, 4c, 4d, 4g, 4j, and 4o exhibited potent anti-proliferative behavior. Among them, compounds 4g, 4j and 4o found to be the most active members exhibiting remarkable growth inhibitory activity. Molecular docking facilitates to investigate the probable binding mode and key active site interactions in tubulins α and β proteins. The docking results are complementary to experimental results.

Sign in / Sign up

Export Citation Format

Share Document