scholarly journals Insulin Inhibits Cardiac Mesoderm, Not Mesendoderm, Formation During Cardiac Differentiation of Human Pluripotent Stem Cells and Modulation of Canonical Wnt Signaling Can Rescue This Inhibition

Stem Cells ◽  
2013 ◽  
Vol 31 (3) ◽  
pp. 447-457 ◽  
Author(s):  
Xiaojun Lian ◽  
Jianhua Zhang ◽  
Kexian Zhu ◽  
Timothy J. Kamp ◽  
Sean P. Palecek
Keyword(s):  
Stem Cells ◽  
Wnt Signaling ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Cardiac Differentiation ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt ◽  
Cardiac Mesoderm

scholarly journals Phasic modulation of Wnt signaling enhances cardiac differentiation in human pluripotent stem cells by recapitulating developmental ontogeny

2014 ◽  
Vol 1843 (11) ◽  
pp. 2394-2402 ◽  
Author(s):  
Ashish Mehta ◽  
Chrishan J.A. Ramachandra ◽  
Glen L. Sequiera ◽  
Yuliansa Sudibyo ◽  
Manasi Nandihalli ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wnt Signaling ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Cardiac Differentiation

scholarly journals Chalcone Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering

ChemMedChem ◽  
2021 ◽  
Author(s):  
Farah Raad ◽  
Taukeer A Khan ◽  
Tilman U. Esser ◽  
James E. Hudson ◽  
Bhakti Irene Seth ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Heart Muscle ◽  
Human Pluripotent Stem Cells ◽  
Mesoderm Induction ◽  
Cardiac Mesoderm

scholarly journals Transition between canonical to non-canonical Wnt signaling during interactions between mesenchymal stem cells and osteosarcomas

2020 ◽  
pp. 037-048
Author(s):  
Asulin Masha ◽  
Ghedalia-Peled Noa Ben ◽  
Erez Ifat Cohen ◽  
Ventura Yvonne ◽  
Vago Razi
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Wnt Signaling ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

scholarly journals Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

2021 ◽  
Vol 118 (34) ◽  
pp. e2108145118
Author(s):  
Anja Bufe ◽  
Ana García del Arco ◽  
Magdalena Hennecke ◽  
Anchel de Jaime-Soguero ◽  
Matthias Ostermaier ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Division ◽  
Wnt Signaling ◽  
Pluripotent Stem Cells ◽  
Target Genes ◽  
Genome Maintenance ◽  
Spindle Poles ◽  
Chromosome Congression ◽  
Chromosome Alignment ◽  
Canonical Wnt

Canonical Wnt signaling plays critical roles in development and tissue renewal by regulating β-catenin target genes. Recent evidence showed that β-catenin–independent Wnt signaling is also required for faithful execution of mitosis. However, the targets and specific functions of mitotic Wnt signaling still remain uncharacterized. Using phosphoproteomics, we identified that Wnt signaling regulates the microtubule depolymerase KIF2A during mitosis. We found that Dishevelled recruits KIF2A via its N-terminal and motor domains, which is further promoted upon LRP6 signalosome formation during cell division. We show that Wnt signaling modulates KIF2A interaction with PLK1, which is critical for KIF2A localization at the spindle. Accordingly, inhibition of basal Wnt signaling leads to chromosome misalignment in somatic cells and pluripotent stem cells. We propose that Wnt signaling monitors KIF2A activity at the spindle poles during mitosis to ensure timely chromosome alignment. Our findings highlight a function of Wnt signaling during cell division, which could have important implications for genome maintenance, notably in stem cells.

scholarly journals Inhibition versus activation of canonical Wnt-signaling, to promote chondrogenic differentiation of Mesenchymal Stem Cells. A review.

2021 ◽  
Author(s):  
Nikitas P. Schizas ◽  
Christos Zafeiris ◽  
Anna-Aikaterini Neri ◽  
Panagiotis P. Anastasopoulos ◽  
Nikolaos A. Papaioannou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Wnt Signaling ◽  
Chondrogenic Differentiation ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt
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