scholarly journals Lineage-Specific Early Differentiation of Human Embryonic Stem Cells Requires a G2 Cell Cycle Pause

Stem Cells ◽  
2016 ◽  
Vol 34 (7) ◽  
pp. 1765-1775 ◽  
Author(s):  
Jennifer J. Van Oudenhove ◽  
Rodrigo A. Grandy ◽  
Prachi N. Ghule ◽  
Roxana del Rio ◽  
Jane B. Lian ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Early Differentiation

Ethanol alters cell cycle gene expression in human embryonic stem cells

2016 ◽  
Vol 01 (03) ◽  
pp. 201-208 ◽  
Author(s):  
Malini Krishnamoorthy ◽  
Brian Gerwe ◽  
Jamie Heimburg-Molinaro ◽  
Rachel Nash ◽  
Jagan Arumugham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Gene ◽  
Cell Cycle Gene Expression

Label-Free Determination of the Cell Cycle Phase in Human Embryonic Stem Cells by Raman Microspectroscopy

2013 ◽  
Vol 85 (19) ◽  
pp. 8996-9002 ◽  
Author(s):  
Stanislav O. Konorov ◽  
H. Georg Schulze ◽  
James M. Piret ◽  
Michael W. Blades ◽  
Robin F. B. Turner
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Raman Microspectroscopy ◽  
Cell Cycle Phase ◽  
Cycle Phase ◽  
Label Free

Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells

2007 ◽  
Vol 21 (11) ◽  
pp. 2807-2817 ◽  
Author(s):  
Dana Egozi ◽  
Maanit Shapira ◽  
Galit Paor ◽  
Ofer Ben‐Izhak ◽  
Karl Skorecki ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Ubiquitin Ligase ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Inhibitor

scholarly journals Impact of AHR Ligand TCDD on Human Embryonic Stem Cells and Early Differentiation

2020 ◽  
Vol 21 (23) ◽  
pp. 9052
Author(s):  
Indrek Teino ◽  
Antti Matvere ◽  
Martin Pook ◽  
Inge Varik ◽  
Laura Pajusaar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Target Genes ◽  
Expression Patterns ◽  
Embryonic Stem ◽  
Stem Cell Differentiation ◽  
Cell Types ◽  
Early Differentiation

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which mediates the effects of a variety of environmental stimuli in multiple tissues. Recent advances in AHR biology have underlined its importance in cells with high developmental potency, including pluripotent stem cells. Nonetheless, there is little data on AHR expression and its role during the initial stages of stem cell differentiation. The purpose of this study was to investigate the temporal pattern of AHR expression during directed differentiation of human embryonic stem cells (hESC) into neural progenitor, early mesoderm and definitive endoderm cells. Additionally, we investigated the effect of the AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the gene expression profile in hESCs and differentiated cells by RNA-seq, accompanied by identification of AHR binding sites by ChIP-seq and epigenetic landscape analysis by ATAC-seq. We showed that AHR is differentially regulated in distinct lineages. We provided evidence that TCDD alters gene expression patterns in hESCs and during early differentiation. Additionally, we identified novel potential AHR target genes, which expand our understanding on the role of this protein in different cell types.

Connexin 43 is involved in early differentiation of human embryonic stem cells

2019 ◽  
Vol 105 ◽  
pp. 33-44 ◽  
Author(s):  
Qian Peng ◽  
Chaomin Yue ◽  
Andy Chun Hang Chen ◽  
Kai Chuen Lee ◽  
Sze Wan Fong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Connexin 43 ◽  
Embryonic Stem ◽  
Early Differentiation

Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture

2013 ◽  
Vol 238 (3) ◽  
pp. 271-275 ◽  
Author(s):  
Tomas Barta ◽  
Dasa Dolezalova ◽  
Zuzana Holubcova ◽  
Ales Hampl
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Culture ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Cell Cycle Regulation ◽  
Embryonic Stem ◽  
Cycle Regulation

scholarly journals Differentiation is coupled to changes in the cell cycle regulatory apparatus of human embryonic stem cells

2007 ◽  
Vol 1 (1) ◽  
pp. 45-60 ◽  
Author(s):  
Adam A. Filipczyk ◽  
Andrew L. Laslett ◽  
Christine Mummery ◽  
Martin F. Pera
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem
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