Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells

2007 ◽  
Vol 21 (11) ◽  
pp. 2807-2817 ◽  
Author(s):  
Dana Egozi ◽  
Maanit Shapira ◽  
Galit Paor ◽  
Ofer Ben‐Izhak ◽  
Karl Skorecki ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Ubiquitin Ligase ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Inhibitor

Ethanol alters cell cycle gene expression in human embryonic stem cells

2016 ◽  
Vol 01 (03) ◽  
pp. 201-208 ◽  
Author(s):  
Malini Krishnamoorthy ◽  
Brian Gerwe ◽  
Jamie Heimburg-Molinaro ◽  
Rachel Nash ◽  
Jagan Arumugham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Gene ◽  
Cell Cycle Gene Expression

Label-Free Determination of the Cell Cycle Phase in Human Embryonic Stem Cells by Raman Microspectroscopy

2013 ◽  
Vol 85 (19) ◽  
pp. 8996-9002 ◽  
Author(s):  
Stanislav O. Konorov ◽  
H. Georg Schulze ◽  
James M. Piret ◽  
Michael W. Blades ◽  
Robin F. B. Turner
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Raman Microspectroscopy ◽  
Cell Cycle Phase ◽  
Cycle Phase ◽  
Label Free

scholarly journals Differentiation is coupled to changes in the cell cycle regulatory apparatus of human embryonic stem cells

2007 ◽  
Vol 1 (1) ◽  
pp. 45-60 ◽  
Author(s):  
Adam A. Filipczyk ◽  
Andrew L. Laslett ◽  
Christine Mummery ◽  
Martin F. Pera
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem

scholarly journals JMJD5 Regulates Cell Cycle and Pluripotency in Human Embryonic Stem Cells

Stem Cells ◽  
2014 ◽  
Vol 32 (8) ◽  
pp. 2098-2110 ◽  
Author(s):  
Hui Zhu ◽  
Shijun Hu ◽  
Julie Baker
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem

scholarly journals A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

2009 ◽  
Vol 184 (1) ◽  
pp. 67-82 ◽  
Author(s):  
Xin Zhang ◽  
Irina Neganova ◽  
Stefan Przyborski ◽  
Chunbo Yang ◽  
Michael Cooke ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
S Phase ◽  
Down Regulation ◽  
Phase Regulation ◽  
The Impact ◽  
Phase Entry

In this study, we show that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components. Chromatin immunoprecipitation combined with reporter-based transfection assays show that the C-terminal region of NANOG binds to the regulatory regions of CDK6 and CDC25A genes under normal physiological conditions. Decreased CDK6 and CDC25A expression in hESCs suggest that both CDK6 and CDC25A are involved in S-phase regulation. The effects of NANOG overexpression on S-phase regulation are mitigated by the down-regulation of CDK6 or CDC25A alone. Overexpression of CDK6 or CDC25A alone can rescue the impact of NANOG down-regulation on S-phase entry, suggesting that CDK6 and CDC25A are downstream cell cycle effectors of NANOG during the G1 to S transition.

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