Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin

Stem Cells ◽  
2019 ◽  
Vol 37 (11) ◽  
pp. 1389-1400 ◽  
Author(s):  
Juanjuan Shan ◽  
Junjie Shen ◽  
Min Wu ◽  
Haijun Zhou ◽  
Juan Feng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
The Self ◽  
Erk Signaling ◽  
Self Renewal ◽  
Liver Cancer Stem Cells

scholarly journals Inhibition of β‑catenin protein expression by triptolide affects self-renewal of liver cancer stem cells

2015 ◽  
Vol 10 (2) ◽  
pp. 455 ◽  
Author(s):  
Jian-Bo Zhou ◽  
Gang Peng ◽  
Yu-Cheng Jia ◽  
Jun Li ◽  
Jia Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Inhibitory Concentration ◽  
The Self ◽  
Tripterygium Wilfordii ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Novel Agent

<p>The present study demonstrates the effects of triptolide, one of the constituents from Tripterygium wilfordii, on the self‑renewal capacity of human hepatocellular carcinoma. The investigation revealed that triptolide markedly prevented the proliferation of liver cancer stem cells (LCSCs). For the LCSCs the minimum inhibitory concentration of triptolide was 0.6 μM. There was a significant and obvious decrease in the capacity of LCSCs to form self-sphere. Furthermore, triptolide reduced the sphere-forming capacity of LCSCs along with inhibition of β‑catenin expression. However, the exposure of triptolide-treated cells to lithium chloride, an activator the Wnt/β-catenin signaling pathway, reversed the triptolide-induced inhibition of β-catenin expression and inhibited the self-renewal capacity. Therefore, triptolide effectively eradicates LCSCs through the inhibition of β-catenin protein and may act as a novel agent for the treatment of hepatocellular carcinoma.</p><p> </p>

scholarly journals FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells

Theranostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 5045-5060
Author(s):  
Jingchun Wang ◽  
Huakan Zhao ◽  
Lu Zheng ◽  
Yu Zhou ◽  
Lei Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
The Self ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Signaling Circuit

The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling

2019 ◽  
Vol 70 (5) ◽  
pp. 918-929 ◽  
Author(s):  
Jiayi Wu ◽  
Pingping Zhu ◽  
Tiankun Lu ◽  
Ying Du ◽  
Yanying Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Hedgehog Signaling ◽  
The Self ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals SOX9-transactived long non-coding RNA NEAT1 promotes the self-renewal of liver cancer stem cells through PKA/Hippo signaling

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhuo Cheng ◽  
Xijun Liang ◽  
Cheng Zhang ◽  
Ruoyu Wang ◽  
Tingting Wei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
The Self ◽  
Hippo Signaling ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals COL14A1 promotes self-renewal of human liver cancer stem cells through activation of ERK signaling

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ruijiao Kong ◽  
Haidong Liu ◽  
Yi Shi ◽  
Qiuhong Man ◽  
Shanrong Liu
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Erk Signaling ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer

scholarly journals MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axis

2018 ◽  
Vol 37 (1) ◽  
Author(s):  
Yu-Shui Ma ◽  
Zhong-Wei Lv ◽  
Fei Yu ◽  
Zheng-Yan Chang ◽  
Xian-Ling Cong ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
The Self ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Cell Cycle Entry

scholarly journals The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling

2015 ◽  
Vol 16 (4) ◽  
pp. 413-425 ◽  
Author(s):  
Yanying Wang ◽  
Lei He ◽  
Ying Du ◽  
Pingping Zhu ◽  
Guanling Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Wnt Signaling ◽  
Long Noncoding Rna ◽  
Human Liver ◽  
Noncoding Rna ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer

scholarly journals ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway

2020 ◽  
Vol 472 ◽  
pp. 70-80 ◽  
Author(s):  
Nuozhou Wang ◽  
Ming-yue Li ◽  
Yi Liu ◽  
Jianqing Yu ◽  
Jianwei Ren ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Signaling Pathway ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Notch1 Signaling ◽  
Notch1 Signaling Pathway

Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells

2017 ◽  
Vol 400 ◽  
pp. 149-160 ◽  
Author(s):  
Zhixin Liu ◽  
Xuechen Dai ◽  
Tianci Wang ◽  
Chengcheng Zhang ◽  
Wenjun Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Hepatitis B Virus ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Hepatitis B ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
B Virus

scholarly journals C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Pingping Zhu ◽  
Yanying Wang ◽  
Ying Du ◽  
Lei He ◽  
Guanling Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Self Renewal ◽  
Liver Cancer Stem Cells
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