Cytokines and local factors which affect osteoclast function

Paget’s disease is a chronic disorder of bone remodeling, characterized by an abnormal increase of osteoclast and, hence, osteoblast activity. The imbalance of bone turnover results in the formation of unhealthy and fragile bone. It also leads to impairment of adjacent joints and to a risk of various complications. Current research focuses on the elucidation of the etiologic role viral infection and predisposing genetic factors. Paget’s disease is commonly discovered by chance; its suspicion is raised either by high level of alkaline phosphatase or by the X-ray of the pathological bone. Bisphosphonates have proven to be effective in controlling disease activity because they inhibit osteoclast function. Their use is recommended when bone-derived serum alkaline phosphatase is high and/or when disease localizations are highly suspected for the development of complications. Orv. Hetil., 2011, 152, 1337–1346.

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Hoe tweederangs zijn lokale verkiezingen? Een analyse van de Nederlandse gemeenteraadsverkiezingen van 2010 en 1998 vanuit het perspectief van second-order elections. (Municipal Elections as Second-Order Elections. Assessing the Impact of National and Local Factors on the Vote-Shares for Parties in the Dutch Muncipal Elections of 1998 and 2010.)

SSRN Electronic Journal ◽

10.2139/ssrn.2404916 ◽

2013 ◽

Author(s):

Herman Lelieveldt ◽

Ramon Van der Does

Keyword(s):

Second Order ◽

Municipal Elections ◽

Local Factors ◽

The Impact

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Local Factors and the Gains from International Diversification

SSRN Electronic Journal ◽

10.2139/ssrn.965984 ◽

2007 ◽

Author(s):

Zhe Zhang ◽

Cheol S. Eun ◽

Sandy Lai

Keyword(s):

International Diversification ◽

Local Factors

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Comparative Clinical study of Jatyadi Taila and Jatyadi Ghrita in the management of Dushta Vrana

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v3i3.12875 ◽

2018 ◽

Vol 3 (3) ◽

Author(s):

Rajendra Joshi ◽

N. B. Mashetti ◽

Rakesh Kumar Gujar

Keyword(s):

Clinical Study ◽

Burning Sensation ◽

Normal Process ◽

Surgical Practice ◽

Local Factors ◽

Significant Difference ◽

Comparative Clinical Study ◽

Group A ◽

Contaminated Wound ◽

Group B

Dushta Vrana is a common and frequently encountered problem faced in surgical practice. The presence of Dushta Vrana worsens the condition of the patient with different complications and may become fatal. Local factors on wound like slough, infection and foreign body, affect the normal process of healing. A healthy wound in a normal body heals earlier with a minimum scar as compared to a contaminated wound. Therefore in this study all the efforts are made to make a Dushta Vrana into a Shuddha Vrana. Once the Vrana becomes Shuddha, Ropana of the Vrana will start. The objective of the study was to evaluate the clinical efficacy of Jatyadi Taila and Jatyadi Ghrita in Dushta Vrana. Clinically diagnosed 60 Patients of Dushta Vrana were randomly divided into two groups, each consisting of 30 Patients. Group A were treated with the Jatyadi Taila and Group B was treated by Jatyadi Ghrita. The results observed was based on the relief obtained on the subjective and objective parameters taken for consideration for this study viz, size of ulcer, discharge, smell, pain, burning sensation, itching and granulation were found significant (P Lass Than 0.05). On the basis of assessment criteria and overall result of treatment, the patients of Jatyadi Taila group showed better results when compared to Jatyadi Ghrita group. Even though statistically there is no much significant difference between the two groups, but by seeing the effect on individual parameters (subjective and objective) and over all response, Jatyadi Taila seems to be effective when compared to Jatyadi Ghrita. It is having more Ropana qualities when compared to Shodhana.

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Movilidad laboral geográfica en un antiguo enclave minero. La inversión de un mercado de trabajo local

región y sociedad ◽

10.22198/rys.1999.18.a764 ◽

2016 ◽

Vol 11 (18) ◽

Author(s):

Camilo Contreras Delgado

Keyword(s):

Labor Market ◽

Labor Markets ◽

Economic History ◽

Labor Mobility ◽

Work Place ◽

Local Labor Markets ◽

Local Labor Market ◽

Local Factors ◽

The Social ◽

History Of

Resumen:Este artículo examina los fa c t o res internos y externos a una localidad que son copartícipes en la estructuración y reestructuración de su mercado de trabajo local. A partir de la revisión de la historia social y económica del lugar, se destaca su tránsito de enclave minero a lugar de residencia de mineros y trabajadores de maquiladoras. En este caso, se presenta la constitución de los mercados de trabajo locales como un resultado del encuentro de las condiciones del lugar de residencia de los trabajadores y el lugar donde se encuentra el centro de trabajo. De aquí que la movilidad laboral geográfica aparezca como una de las tácticas de los sujetos ante una situación de desempleo.Palabras clave: Mercado de trabajo, Minería, Maquiladoras, Mineros, Movilidad laboral, Desempleo.Abstract:This article examines the internal and external local factors shaping the structuring and restructuring of a local labor market. By reviewing the social and economic history of the community, this article underlines its transition from a mining setting to a residence place for miners and maquila workers. In this case, the constitution of local labor markets is presented as a result of the condition encounter of both workers residence place and the location of the work place. This is a reason explaining why geographical labor mobility comes to be an actor tactic to face unemployment.Key words: Labor market, Mining, Export-oriented industry, Miners, Labor mobility, Unemployment.

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