Preconditioning by Phosphodiesterase-5 Inhibition Improves Therapeutic Efficacy of Adipose-Derived Stem Cells Following Myocardial Infarction in Mice

Stem Cells ◽  
2012 ◽  
Vol 30 (2) ◽  
pp. 326-335 ◽  
Author(s):  
Nicholas N. Hoke ◽  
Fadi N. Salloum ◽  
David A. Kass ◽  
Anindita Das ◽  
Rakesh C. Kukreja
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Therapeutic Efficacy ◽  
Adipose Derived Stem Cells ◽  
Phosphodiesterase 5

493 Inhibition of phosphodiesterase-5 improves therapeutic efficacy of adipose-derived stem cells for erectile dysfunction in diabetic rats

2014 ◽  
Vol 13 (1) ◽  
pp. e493
Author(s):  
J. Yang ◽  
T. Wang ◽  
Y. Zhang ◽  
L. Zhuan ◽  
H. Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Erectile Dysfunction ◽  
Therapeutic Efficacy ◽  
Diabetic Rats ◽  
Adipose Derived Stem Cells ◽  
Phosphodiesterase 5

MP43-12 INHIBITION OF PHOSPHODIESTERASE-5 IMPROVES THERAPEUTIC EFFICACY OF ADIPOSE-DERIVED STEM CELLS FOR ERECTILE DYSFUNCTION IN DIABETIC RATS

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Jun Yang ◽  
Tao Wang ◽  
Yan Zhang ◽  
Li Zhuan ◽  
Hua Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Erectile Dysfunction ◽  
Therapeutic Efficacy ◽  
Diabetic Rats ◽  
Adipose Derived Stem Cells ◽  
Phosphodiesterase 5

Preconditioning of adipose‐derived stem cells by phosphodiesterase‐5 inhibition enhances therapeutic efficacy against diabetes‐induced erectile dysfunction

Andrology ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 231-240 ◽  
Author(s):  
J. Yang ◽  
Z. Yu ◽  
Y. Zhang ◽  
G.‐H. Zang ◽  
L. Zhuan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Erectile Dysfunction ◽  
Therapeutic Efficacy ◽  
Adipose Derived Stem Cells ◽  
Phosphodiesterase 5

Pretreatment of rat bone marrow mesenchymal stem cells with a combination of hypergravity and 5-azacytidine enhances therapeutic efficacy for myocardial infarction

2011 ◽  
Vol 27 (2) ◽  
pp. 473-482 ◽  
Author(s):  
Shu-Kuan Ling ◽  
Rui Wang ◽  
Zhong-Quan Dai ◽  
Jie-Lin Nie ◽  
Hong-Hui Wang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Efficacy ◽  
Marrow Mesenchymal Stem Cells ◽  
Rat Bone

Abstract 3899: SDF-1α Mediates the Therapeutic Effect of Human Adipose-Derived Stem Cells on Acute Myocardial Infarction Recruiting Bone Marrow-Derived Endothelial Progenitor Cells

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Masaaki Ii ◽  
Ayumi Yokoyama ◽  
Miki Horii ◽  
Hiroshi Akimaru ◽  
Takayuki Asahara
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Cardiac Function ◽  
Therapeutic Effect ◽  
Heart Diseases ◽  
Capillary Density ◽  
Ischemic Myocardium ◽  
Control Group ◽  
Adipose Derived Stem Cells ◽  
Ischemic Heart Diseases

Background: Recently, human multipotent adipose-derived stem cells (hMADSs) have been isolated featuring extensive expansion capacity ex vivo. However, little is known about the therapeutic efficacy of hMADS in ischemic heart diseases. We tested the hypothesis that hMADS transplantation may contribute to cardiac functional recovery following myocardial infarction (MI). Methods and Results: Nude rats were either transplanted with hMADSs (5x10 5 /rat, n=10) or PBS (control, n=9) in ischemic myocardium immediately following MI induction. The cardiac function, infarct size and capillary density in the peri-infarct area were evaluated by echocardiography and immunostaining 28 days after surgery. The cardiac function was significantly greater with increased capillary density and reduced fibrosis area in the hMADS group than that in the control group. Next, we examined tissue regeneration in the infarct heart by the transplanted hMADSs. However, remarkable differentiation of hMADSs into any cardiac cell lineages was not detected. To explore another mechanism for the favorable effect of hMADSs, we further examined mRNA expression of cytokines in hMADSs under hypoxic conditions. Although hypoxia decreased the expressions, robust VEGF, bFGF, and SDF-1α expressions were detected in hMADSs. Notably, the stem/progenitor chemokine SDF-1α expression in hMADSs was significantly greater than that in human mesenchymal stem cells that are well known to have a therapeutic effect on ischemic heart diseases. We then focused on SDF-1α /CXCR4 axis and examined the contribution of bone marrow (BM)-derived endothelial progenitor cells (EPCs), that have CXCR4 receptor for SDF-1v, to ischemic myocardium using a Tie2/LacZ BM transplantation nude mouse model. β-gal positive EPCs are frequently observed in ischemic myocardium in the hMADS group compared to the control group. Conclusion: hMADSs exhibit a therapeutic effect on cardiac function following MI with the production of VEGF, bFGF, and SDF-1α demonstrating paracrine effects rather than direct contribution to cardiac regeneration. These findings suggest that transplanted hMADSs and recruited EPCs may synergistically promote angiogenesis playing a role in ischemic myocardium.

scholarly journals Transplantation of autologous adipose-derived stem cells ameliorates cardiac function in rabbits with myocardial infarction

2007 ◽  
Vol 120 (4) ◽  
pp. 300-307 ◽  
Author(s):  
Duan-zhen ZHANG ◽  
Lu-yue GAI ◽  
Hong-wei LIU ◽  
Qin-hua JIN ◽  
Jian-hua HUANG ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Cardiac Function ◽  
Adipose Derived Stem Cells

scholarly journals Acute myocardial infarction does not affect functional characteristics of adipose-derived stem cells in rats, but reduces the number of stem cells in adipose tissue

2015 ◽  
Vol 362 (3) ◽  
pp. 623-632 ◽  
Author(s):  
B. A. Naaijkens ◽  
P. A. J. Krijnen ◽  
E. Meinster ◽  
E. N. ter Horst ◽  
K. Vo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cells ◽  
Adipose Tissue ◽  
Adipose Derived Stem Cells ◽  
Functional Characteristics

scholarly journals Danhong Injection Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in Myocardial Infarction by Promoting Angiogenesis

2018 ◽  
Vol 9 ◽  
Author(s):  
Jingrui Chen ◽  
Jing Wei ◽  
Yuting Huang ◽  
Yuling Ma ◽  
Jingyu Ni ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Efficacy ◽  
Danhong Injection
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