Empirical research in systems engineering: challenges and opportunities of a new frontier

2009 ◽  
Vol 12 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Ricardo Valerdi ◽  
Heidi L. Davidz
Keyword(s):  
Empirical Research ◽  
Systems Engineering ◽  
New Frontier ◽  
Challenges And Opportunities

scholarly journals Challenges and opportunities in the integration of the Systems Engineering process and the AI/ML model lifecycle

2019 ◽  
Vol 29 (1) ◽  
pp. 560-575
Author(s):  
Jose María Alvarez‐Rodríguez ◽  
Roy Mendieta Zuñiga ◽  
Valentín Moreno Pelayo ◽  
Juan Llorens
Keyword(s):  
Systems Engineering ◽  
Engineering Process ◽  
Challenges And Opportunities

scholarly journals Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 457
Author(s):  
Miriam Sarkis ◽  
Andrea Bernardi ◽  
Nilay Shah ◽  
Maria M. Papathanasiou
Keyword(s):  
Systems Engineering ◽  
Drug Product ◽  
High Specificity ◽  
Supply Chain Design ◽  
Pharmaceutical Manufacturing ◽  
Research Directions ◽  
Process Systems ◽  
Challenges And Opportunities ◽  
Complex Drug

The rise of personalised and highly complex drug product profiles necessitates significant advancements in pharmaceutical manufacturing and distribution. Efforts to develop more agile, responsive, and reproducible manufacturing processes are being combined with the application of digital tools for seamless communication between process units, plants, and distribution nodes. In this paper, we discuss how novel therapeutics of high-specificity and sensitive nature are reshaping well-established paradigms in the pharmaceutical industry. We present an overview of recent research directions in pharmaceutical manufacturing and supply chain design and operations. We discuss topical challenges and opportunities related to small molecules and biologics, dividing the latter into patient- and non-specific. Lastly, we present the role of process systems engineering in generating decision-making tools to assist manufacturing and distribution strategies in the pharmaceutical sector and ultimately embrace the benefits of digitalised operations.

scholarly journals Organizing Multi-Enzyme Systems into Programmable Materials for Biocatalysis

Catalysts ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 409
Author(s):  
Min-Ju Seo ◽  
Claudia Schmidt-Dannert
Keyword(s):  
Enzyme Catalysis ◽  
Cascade Reactions ◽  
Operational Performance ◽  
Cell Factories ◽  
Self Assembling ◽  
Enzyme Discovery ◽  
New Frontier ◽  
Challenges And Opportunities ◽  
New Strategies

Significant advances in enzyme discovery, protein and reaction engineering have transformed biocatalysis into a viable technology for the industrial scale manufacturing of chemicals. Multi-enzyme catalysis has emerged as a new frontier for the synthesis of complex chemicals. However, the in vitro operation of multiple enzymes simultaneously in one vessel poses challenges that require new strategies for increasing the operational performance of enzymatic cascade reactions. Chief among those strategies is enzyme co-immobilization. This review will explore how advances in synthetic biology and protein engineering have led to bioinspired co-localization strategies for the scaffolding and compartmentalization of enzymes. Emphasis will be placed on genetically encoded co-localization mechanisms as platforms for future autonomously self-organizing biocatalytic systems. Such genetically programmable systems could be produced by cell factories or emerging cell-free systems. Challenges and opportunities towards self-assembling, multifunctional biocatalytic materials will be discussed.

scholarly journals Challenges And Opportunities For Improving Patient Safety Through Human Factors And Systems Engineering

2018 ◽  
Vol 37 (11) ◽  
pp. 1862-1869 ◽  
Author(s):  
Pascale Carayon ◽  
Abigail Wooldridge ◽  
Bat-Zion Hose ◽  
Megan Salwei ◽  
James Benneyan
Keyword(s):  
Patient Safety ◽  
Human Factors ◽  
Systems Engineering ◽  
Challenges And Opportunities
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