VP27.09: Fetal corpus callosum ultrasound analysis with the novel slow flow Doppler method: should it be a screening tool?

A competitive fluorescence immunoassay for the identification and quantification of morphine has been developed on the basis of hapten-coated plate format. Hapten was prepared through covalent conjugating a morphine derivative with albumin bovine. In the immunoassay, the hapten was inoculated on a 96-well plate and then bound with monoclonal antibodies labeled with a signal indicating dye, fluorescein isothiocyanate (FITC). Unbound FITC-antibodies were rinsed off from the plate. The fluorescein intensity decreases in the presence of morphine molecules due to the competitively binding to antibodies against hapten. The intensity is inversely correlated with the concentration of morphine. In quantitative analysis for urine samples, we obtained a linearity range of 0.2 μg/mL∼2.5 μg/mL, along with a detection limit of c.a. 1 ng/mL. The fluorescence immunoassay shows low cross-reactivity (below 10%) to 6-acetylmorphine, 3-acetylmorphine, and heroine. The developed method produced comparable results to the standard GC-MS/MS method. In conclusion, a rapid and efficient screening tool for morphine in clinical human urine has been established.

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The novel geriatric screening tool and retrospective validation in older patients with cancer

Journal of Geriatric Oncology ◽

10.1016/j.jgo.2014.06.037 ◽

2014 ◽

Vol 5 ◽

pp. S16-S17

Author(s):

J.W. Kim ◽

S.-H. Kim ◽

Y.J. Kim ◽

K.-W. Lee ◽

J.-O. Lee ◽

...

Keyword(s):

Older Patients ◽

Screening Tool ◽

The Novel ◽

Patients With Cancer ◽

Geriatric Screening

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Coronaviruses and the Chemical Senses: Past, Present, and Future

Chemical Senses ◽

10.1093/chemse/bjaa031 ◽

2020 ◽

Vol 45 (6) ◽

pp. 415-422 ◽

Cited By ~ 21

Author(s):

Robert Pellegrino ◽

Keiland W Cooper ◽

Antonella Di Pizio ◽

Paule V Joseph ◽

Surabhi Bhutani ◽

...

Keyword(s):

Screening Tool ◽

Respiratory Infections ◽

Current Evidence ◽

The Novel ◽

Chemical Senses ◽

True Nature ◽

Social Trends ◽

Chemosensory Ability ◽

The Relationship

Abstract A wealth of rapidly evolving reports suggests that olfaction and taste disturbances may be manifestations of the novel COVID-19 pandemic. While otolaryngological societies worldwide have started to consider chemosensory evaluation as a screening tool for COVID-19 infection, the true nature of the relationship between the changes in chemosensory ability and COVID-19 is unclear. Our goal with this review is to provide a brief overview of published and archived literature, as well as the anecdotal reports and social trends related to this topic up to April 29, 2020. We also aim to draw parallels between the clinical/chemosensory symptomology reported in association to past coronavirus pandemics (such as SARS and MERS) and the novel COVID-19. This review also highlights current evidence on persistent chemosensory disturbances after the infection has resolved. Overall, our analysis pinpoints the need for further studies: (1) to better quantify olfaction and taste disturbances associated with SARS-CoV-2 infection, compared to those of other viral and respiratory infections, (2) to understand the relation between smell, taste, and chemesthesis disturbances in COVID-19, and (3) to understand how persistent are these disturbances after the infection has resolved.

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New Molecular Players in the Development of Callosal Projections

Cells ◽

10.3390/cells10010029 ◽

2020 ◽

Vol 10 (1) ◽

pp. 29

Author(s):

Ray Ku ◽

Masaaki Torii

Keyword(s):

Corpus Callosum ◽

Recent Progress ◽

Neural Circuitry ◽

Projection Neurons ◽

The Novel ◽

Cellular Processes ◽

Axonal Projections ◽

Main Component ◽

Callosal Projection ◽

The Brain

Cortical development in humans is a long and ongoing process that continuously modifies the neural circuitry into adolescence. This is well represented by the dynamic maturation of the corpus callosum, the largest white matter tract in the brain. Callosal projection neurons whose long-range axons form the main component of the corpus callosum are evolved relatively recently with a substantial, disproportionate increase in numbers in humans. Though the anatomy of the corpus callosum and cellular processes in its development have been intensively studied by experts in a variety of fields over several decades, the whole picture of its development, in particular, the molecular controls over the development of callosal projections, still has many missing pieces. This review highlights the most recent progress on the understanding of corpus callosum formation with a special emphasis on the novel molecular players in the development of axonal projections in the corpus callosum.

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Use of the automatic tympanometer as a screening tool for congenital choanal atresia

The Journal of Laryngology & Otology ◽

10.1258/0022215053419925 ◽

2005 ◽

Vol 119 (2) ◽

pp. 125-128 ◽

Cited By ~ 4

Author(s):

Kamal G Effat

Keyword(s):

Congenital Anomaly ◽

Minimally Invasive ◽

Screening Tool ◽

Choanal Atresia ◽

Newborn Infants ◽

The Novel ◽

Simple Method ◽

Distal Obstruction ◽

Novel Method ◽

A Prospective Study

Choanal atresia is a significant congenital anomaly, which may be associated with other congenital anomalies. Recommendations have been previously proposed for neonatal screening of all newborns to detect this condition. A previously unreported, simple method using the automatic tympanometer to screen newborns for congenital choanal atresia is proposed. A prospective study was performed over a one-month period on all newborns at El-Sahel Teaching Hospital, Cairo, to evaluate the efficacy of this manoeuvre. The nostrils of 143 newborn infants were evaluated during the study period. The sensitivity of the technique in diagnosing a patent nostril was 100 per cent. The specificity of the technique for detecting distal obstruction was 100 per cent. There were no complications of the described procedures. The study revealed that the novel method of screening for choanal atresia in newborns using the automatic tympanometer is simple, minimally invasive and highly reproducible.

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Coronaviruses and the Chemical Senses: Past, Present, and Future

10.31219/osf.io/ejv8y ◽

2020 ◽

Cited By ~ 4

Author(s):

Robert Pellegrino ◽

Keiland W Cooper ◽

Antonella Di Pizio ◽

Paule Valery Joseph ◽

Surabhi Bhutani ◽

...

Keyword(s):

Screening Tool ◽

Respiratory Infections ◽

Current Evidence ◽

The Novel ◽

Chemical Senses ◽

True Nature ◽

Social Trends ◽

Chemosensory Ability ◽

The Relationship

A wealth of rapidly evolving reports suggests that olfaction and taste disturbances may be manifestations of the novel COVID-19 pandemic. While otolaryngological societies worldwide have started to consider chemosensory evaluation as a screening tool for COVID-19 infection, the true nature of the relationship between the changes in chemosensory ability and COVID-19 is unclear. Our goal with this review is to provide a brief overview of published and archived literature, as well as the anecdotal reports and social trends related to this topic up to April 29, 2020. We also aim to draw parallels between the clinical/chemosensory symptomology reported in association to past coronavirus pandemics (such as SARS and MERS) and the novel COVID-19. This review also highlights current evidence on persistent chemosensory disturbances after the infection has resolved. Overall, our analysis pinpoints the need for further studies: 1) to better quantify olfaction and taste disturbances associated with SARS-CoV-2 infection, compared to those of other viral and respiratory infections, 2) to understand the relation between smell, taste, and chemesthesis disturbances in COVID-19, and 3) to understand how persistent are these disturbances after the infection has resolved.

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Monitoring Inflow Dynamics in a Multipurpose Dam Based on Travel-Time Principle

10.21203/rs.3.rs-581117/v1 ◽

2021 ◽

Author(s):

Mohamad Basel Al Sawaf ◽

kiyosi Kawanisi ◽

Cong Xiao ◽

Gillang Noor ◽

Faruq Khadami ◽

...

Keyword(s):

Travel Time ◽

Management Practices ◽

Sound Propagation ◽

Flow Direction ◽

Slow Flow ◽

The Novel ◽

Flow Environment ◽

Dam Operation ◽

Dam Inflow ◽

Acoustic Travel Time

Abstract Understanding inflow dynamics in a dam lake forms the basis for optimal dam operation and management practices. However, methods pertaining to adequately determining negative inflows and addressing them, as well as quantifying uncertainties in dam inflow, have been scarcely investigated. In this study, the inflow was observed using two pairs of fluvial acoustic tomography (FAT) systems placed diagonally in a dam lake, forming a crossed-shaped pattern. The “travel-time” principle is the primary approach for measuring the inflow by FAT. The novelty of this study is in discussing the inflow characteristics within a slow water-flow environment monitored by FAT. Based on the reciprocal sound transmission, we upgraded an equation to estimate the flow direction; this newly proposed generalized equation can be used in a fluctuating flow environment. We also discussed the sound propagation characteristics for slow flow velocities. Finally, we demonstrated that a small inaccuracy in the acoustic signal, even by a sub-millisecond, can cause significant errors in measurements. One of the novel findings of this study is the detection of internal waves using the improved flow direction equation and acoustic travel-time records. Overall, this study presents a promising approach for inflow measurements under extremely slow flow conditions.

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THE NOVEL FRAILTY INDEX (NFI) CORRELATES WITH A VALUE OF PHASE ANGLE AND MNA IN HOSPITALISED AND FREELIVING ELDERLY - PRELIMINARY REPORT

Journal of Aging Research and Lifestyle ◽

10.14283/jarcp.2018.21 ◽

2018 ◽

pp. 1-5

Author(s):

E. Wernio ◽

J.A. Dardzinska, ◽

H. Kujawska-Danecka ◽

A. Hajduk ◽

Z. Zdrojewski ◽

...

Keyword(s):

Nutritional Status ◽

Phase Angle ◽

Screening Tool ◽

Frailty Index ◽

The Elderly ◽

The Novel ◽

Frailty Syndrome ◽

A Value ◽

Co Morbidity

Introduction: To improve the quality of life and health of the elderly, attention is paid to the early detection of frailty syndrome. Unfortunately, one simple and practical screening tool has not been established yet. Recently came the proposal of the Novel Frailty Index (NFI) created by Yamada and Arai. Therefore, the purpose of this study was to assess the relationship between nutritional status and NFI of the elderly. Materials and methods: In a group of 67 elderly patients (27 hospitalised and 40 living in the home environment) we used the NFI and evaluated nutritional status with the use of full-MNA together with SNAQ (appetite questionnaire), manual dynamometry and bioimpedance analysis. Results: Based on the NFI results, frailty syndrome was diagnosed in more than half of hospitalised elderly. The syndrome was significantly less prevalent in free-living older people (15% vs 63%, p<0.001).We found the significant correlations of NFI values with age (r=0.031, p=0.03), co-morbidity(r=0.295, p=0.016), phase angle (r=-0.407, p<0.001), full-MNA score (r=-0.515, p<0.001). Conclusions: Our preliminary results suggest the relevant association between NFI results and age, phase angle as well comorbidity and nutritional status. So further evaluation of NFI as a screening tool for frailty syndrome diagnose is needed.

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