OP04.05:
            In vitro
            simulation of acute fetofetal transfusion in case of single intrauterine fetal death in monochorionic twins

AbstractMaternal infection with parvovirus B19 during pregnancy can cause aplastic anemia in the fetus and may lead to nonimmune fetal hydrops and fetal demise. Twin pregnancies complicated by infection due to parvovirus B19 are very rare clinical events. We present a dichorionic, diamniotic, dizygotic twin pregnancy after in vitro fertilization with parvovirus B19 infection and viral transmission to both twins, but different outcomes. At 19 weeks gestation, hydrops fetalis was diagnosed for male twin A, female twin B did not show any abnormalities. At 22 weeks gestation an acute parvovirus B19 infection was detected and twin A was diagnosed with intrauterine fetal death (IUFD) by ultrasound at 23 weeks gestation. Viral DNA was detected in maternal blood as well as in placenta and liver tissue of this twin. Twin B was born at 35 weeks gestation asymptomatically and no signs of hydrops or other congenital anomalies but viral DNA was detected by PCR in serum. At the age of 2 years, both IgG titres against B19 and parvovirus DNA amplification copies were still positive in plasma of the surviving twin, but no clinical signs were detectable. It is remarkable that both twins were infected with parvovirus B19 early in pregnancy but showed a discordant clinical outcome. Our case report describes the rare occurrence of an intrauterine fetal death (IUFD) of one twin and the asymptomatic infection of the other in a twin pregnancy.

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Gestational diabetes insipidus and intrauterine fetal death of monochorionic twins

Journal of Perinatology ◽

10.1038/jp.2008.95 ◽

2008 ◽

Vol 28 (10) ◽

pp. 712-714 ◽

Cited By ~ 7

Author(s):

A Wiser ◽

A Hershko-Klement ◽

A Fishman ◽

N Nachasch ◽

M Fejgin

Keyword(s):

Gestational Diabetes ◽

Diabetes Insipidus ◽

Fetal Death ◽

Intrauterine Fetal Death ◽

Monochorionic Twins

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Modern aspects of tactics in the genital herpes viral infection (literature review)

GYNECOLOGY ◽

10.26442/2079-5696_2018.2.67-73 ◽

2018 ◽

Vol 20 (2) ◽

pp. 67-73

Author(s):

T Yu Pestrikova ◽

E A Yurasova ◽

I V Yurasov ◽

A V Kotelnikova

Keyword(s):

Literature Review ◽

Viral Infection ◽

Genital Herpes ◽

Fetal Death ◽

Malignant Tumors ◽

Adult Population ◽

Viral Disease ◽

Intrauterine Fetal Death ◽

Complicated Course ◽

Simplex Virus

Genital herpes affects all population groups. 98% of the adult population worldwide have antibodies to the herpes simplex virus (HSV-1 or 2). This viral infection is a significant medical and social problem. HSV can lead to a complicated course of pregnancy, causing miscarriages, premature birth, intrauterine fetal death, systemic viral disease in newborns. There is evidence that HSV has a connection with malignant tumors of the prostate and cervix, contributing to their development. This literature review contains modern aspects of epidemiology, etiology, pathogenesis, clinic, diagnosis, treatment of genital herpes, including its recurring forms with valacyclovir (Valvir). Indications for hospitalization of patients with genital herpes were noted and the prognosis of this pathology was determined. The tactics of managing pregnant women with this pathology is presented.

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