P16.14: F-18-fluorodeoxyglucose (FDG) uptake of fetal organs during acute hypoxia measured by positron emission tomography (PET): the pilot study

Gastrointestinal graft-versus-host disease (GVHD) is a common and potentially life-threatening complication after allogeneic hematopoietic stem-cell transplantation (HSCT). Noninvasive tests for assessment of GVHD activity are desirable but lacking. In the present study, we were able to visualize intestinal GVHD-associated inflammation in an allogeneic murine transplantation model by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in vivo. A predominant localization of intestinal GVHD to the colon was verified by histology and fluorescence reflectance imaging of enhanced green fluorescent protein (EGFP)–expressing donor cells. Colonic infiltration by EGFP+ donor lymphocytes matched increased FDG uptake in PET examinations. These preclinical data were prospectively translated into 30 patients with suspected intestinal GVHD beyond 20 days after transplantation. A total of 14 of 17 patients with a diagnostic histology showed significant FDG uptake of the gut, again predominantly in the colon. No increased FDG uptake was detected in 13 patients without histologic evidence of intestinal GVHD. Our findings indicate that FDG-PET is a sensitive and specific noninvasive imaging technique to assess intestinal GVHD, map its localization, and predict and monitor treatment responsiveness. Novel targeted tracers for PET may provide new insights into the pathophysiology of GVHD and bear the potential to further improve GVHD diagnosis.

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Use of laparoscopy as an alternative to computed tomography (CT) and positron emission tomography (PET) scans for the detection of recurrence in patients with gastric cancer: a pilot study

Surgical Endoscopy ◽

10.1007/s00464-011-1722-1 ◽

2011 ◽

Vol 25 (10) ◽

pp. 3338-3344 ◽

Cited By ~ 9

Author(s):

Jung Ho Shim ◽

Han Mo Yoo ◽

Han Hong Lee ◽

Jun Gi Kim ◽

Hae Myung Jeon ◽

...

Keyword(s):

Gastric Cancer ◽

Computed Tomography ◽

Positron Emission Tomography ◽

Pilot Study ◽

Emission Tomography ◽

Positron Emission ◽

Pet Scans

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Positron Emission Tomography/Computed Tomography Predicts and Detects Complications After Endovascular Repair of Abdominal Aortic Aneurysms

Journal of Endovascular Therapy ◽

10.1177/1526602819849088 ◽

2019 ◽

Vol 26 (4) ◽

pp. 520-528 ◽

Cited By ~ 2

Author(s):

Audrey Courtois ◽

Georgios Makrygiannis ◽

Mounia El Hachemi ◽

Rebecka Hultgren ◽

Eric Allaire ◽

...

Keyword(s):

Computed Tomography ◽

Positron Emission Tomography ◽

Endovascular Aneurysm Repair ◽

Aortic Aneurysms ◽

Emission Tomography ◽

Fdg Uptake ◽

Positron Emission ◽

Abdominal Aortic ◽

Pet Ct ◽

D Dimer

Purpose: To assess if aortic 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) could play a role in predicting complications after endovascular aneurysm repair (EVAR). Materials and Methods: This study involved 2 cohorts of men with abdominal aortic aneurysm treated by EVAR: those who underwent a PET/CT scan before EVAR (n=17) and those who had a PET/CT during follow-up (n=34). Uptake of FDG was measured as the standardized uptake value (SUV). D-dimer, a marker of fibrinolysis, was measured in blood drawn concomitantly with the PET/CT. Results: A significant uptake of FDG in the aneurysm wall was detected by PET/CT before EVAR in 6 of 17 patients. During the first year after EVAR, type II endoleaks developed in 5 of these FDG+ patients vs 3 of 11 FDG– patients (p=0.04). Two of the FDG+ patients had continued sac growth and required conversion to open repair. A significant association between sac growth rate, SUV, and the presence of endoleak was found in the 34 patients who underwent PET/CT after EVAR. Finally, D-dimer was significantly increased in patients with both endoleak and positive PET/CT in the post-EVAR group. Conclusion: This study suggests that the presence of FDG uptake in the aortic wall might be a useful tool to predict patients at high risk of developing post-EVAR complications.

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