scholarly journals OP34.07: Placental volume and vascularization by 3-dimensional ultrasound and 3-dimensional power Doppler in the first trimester and the detection of pregnancy induced hypertension or intrauterine growth restriction

2010 ◽  
Vol 36 (S1) ◽  
pp. 151-152
Author(s):  
M. Odeh ◽  
O. Maximovski ◽  
V. Grinin ◽  
E. Ophir ◽  
J. Bornstein
Keyword(s):  
Intrauterine Growth Restriction ◽  
Power Doppler ◽  
First Trimester ◽  
Growth Restriction ◽  
Pregnancy Induced Hypertension ◽  
3 Dimensional ◽  
Intrauterine Growth ◽  
Induced Hypertension ◽  
Placental Volume

scholarly journals First trimester screening for pre-eclampsia and intrauterine growth restriction using three-dimensional Doppler angiography (SPIRIT): protocol for a multicentre prospective study in nulliparous pregnant women

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e037751
Author(s):  
Charline Bertholdt ◽  
Gabriela Hossu ◽  
Claire Banasiak ◽  
Marine Beaumont ◽  
Olivier Morel
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Power Doppler ◽  
First Trimester ◽  
Growth Restriction ◽  
Flow Index ◽  
Intrauterine Growth ◽  
Uncomplicated Pregnancy ◽  
Nulliparous Women ◽  
Biomarker Analysis

IntroductionPre-eclampsia (PE) and intrauterine growth restriction (IUGR) are two major pregnancy complications, related to chronic uteroplacental hypoperfusion. Nowadays, there is no screening or diagnostic test for uteroplacental vascularisation deficiency in pregnant women. Since 2004, 3 three-imensional power Doppler (3DPD) angiography has been used for the evaluation of uteroplacental vascularisation and three vascular indices are usually calculated: Vascularisation Index (VI), Flow Index (FI) and vascularisation-FI (VFI). A high intraobserver and interobserver reproducibility and a potential interest for placental function study were reported by our team and others.The main objective of our study is to determine differences in 3DPD indices at first trimester between pregnancies defined at their outcome as uncomplicated pregnancy, PE (mild and severe) and IUGR in nulliparous women.Methods and analysisThis is a national multicentre prospective cohort study conducted in four French maternity units. We expect to include 2200 women in a period of 36 months. The nulliparous pregnant women will be recruited during their first trimester consultation (11–13+6 gestation week (GW)).The 3DPD and uterine artery Doppler acquisition will be included in the current routine 11–13+6 GW ultrasound. Also, additional blood samples will be taken for biomarker analysis (PAPP-A and P1GF) and biological collection. Uteroplacental VIs (FI and VFI) will be measured. For each subgroup (uncomplicated pregnancy, PE and IUGR), mean values in 3DPD indices will be computed and compared using a pairwise t test with a Bonferroni correction p value adjustment.Ethics and disseminationThe study was approved by the French Ethics Committee, the Comité de Protection des Personnes SUD MEDITERRANEE IV on 13 February 2018 with reference number 17 12 03. The results of this study will be published in a peer-reviewed journal and will be presented at relevant conferences.Trial registration numberNCT03342014; Pre-results. PHRCN-16-0567.

scholarly journals Role of Umbilical Artery Doppler in Predicting Intrauterine Growth Restriction and Foetal Outcome in Pregnant Ladies with Pregnancy Induced Hypertension

2018 ◽  
Vol 7 (1-2) ◽  
pp. 3-8
Author(s):  
Prakash Sharma ◽  
Merina Gyawali ◽  
Sangita Devi Gurung
Keyword(s):  
Intrauterine Growth Restriction ◽  
Umbilical Artery ◽  
Clinical Suspicion ◽  
Growth Restriction ◽  
Pregnancy Induced Hypertension ◽  
Intrauterine Growth ◽  
Induced Hypertension ◽  
Umbilical Artery Doppler ◽  
Foetal Outcome

Introduction: Umbilical artery Doppler is a noninvasive tool in the evaluation of the foetal and uteroplacental circulation. The aim of this study was to evaluate the role of umbilical artery Doppler in pregnancy induced hypertension (PIH) ladies with clinical suspicion of intrauterine growth restriction (IUGR) and to predict the fetal outcome.Methods: A total of 44 singleton pregnancies beyond 34 weeks of pregnancy complicated with pregnancy induced hypertension and clinical suspicion of intrauterine growth restriction were evaluated using ultrasonography and Doppler. Six pregnant ladies were excluded from the study. The umbilical artery systolic/diastolic (S/D) ratio was calculated from a free loop of cord midway between the placenta and insertion of cord. All the pregnant ladies were followed up till delivery. Birth weight, adverse foetal outcome were recorded. Babies were divided into two groups, small for gestational age (SGA) and appropriate for gestational age (AGA) based on Lubchenco growth chart. SGA was considered as IUGR.Results: Abnormal S/D in umbilical artery was seen in 26 pregnant ladies, out of which 22 had an abnormal resistive index (RI). Umbilical artery S/D ratio had a sensitivity of 66.7% and specificity of 28.57%, in diagnosing IUGR. Umbilical artery RI had a sensitivity of 50% and specificity of 28.6% in diagnosing IUGR. Similarly, S/D ratio of the umbilical artery had a sensitivity of 100 %, specificity of 46.2%, in diagnosing adverse foetal outcome. RI was 100% sensitive in diagnosing foetal outcome.Conclusion: Umbilical artery Doppler plays an important role in PIH in diagnosing IUGR and predicting a foetal outcome.

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