Second-trimester plasma homocysteine levels and pregnancy-induced hypertension, preeclampsia, and intrauterine growth restriction

Introduction: Umbilical artery Doppler is a noninvasive tool in the evaluation of the foetal and uteroplacental circulation. The aim of this study was to evaluate the role of umbilical artery Doppler in pregnancy induced hypertension (PIH) ladies with clinical suspicion of intrauterine growth restriction (IUGR) and to predict the fetal outcome.Methods: A total of 44 singleton pregnancies beyond 34 weeks of pregnancy complicated with pregnancy induced hypertension and clinical suspicion of intrauterine growth restriction were evaluated using ultrasonography and Doppler. Six pregnant ladies were excluded from the study. The umbilical artery systolic/diastolic (S/D) ratio was calculated from a free loop of cord midway between the placenta and insertion of cord. All the pregnant ladies were followed up till delivery. Birth weight, adverse foetal outcome were recorded. Babies were divided into two groups, small for gestational age (SGA) and appropriate for gestational age (AGA) based on Lubchenco growth chart. SGA was considered as IUGR.Results: Abnormal S/D in umbilical artery was seen in 26 pregnant ladies, out of which 22 had an abnormal resistive index (RI). Umbilical artery S/D ratio had a sensitivity of 66.7% and specificity of 28.57%, in diagnosing IUGR. Umbilical artery RI had a sensitivity of 50% and specificity of 28.6% in diagnosing IUGR. Similarly, S/D ratio of the umbilical artery had a sensitivity of 100 %, specificity of 46.2%, in diagnosing adverse foetal outcome. RI was 100% sensitive in diagnosing foetal outcome.Conclusion: Umbilical artery Doppler plays an important role in PIH in diagnosing IUGR and predicting a foetal outcome.

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OP34.07: Placental volume and vascularization by 3-dimensional ultrasound and 3-dimensional power Doppler in the first trimester and the detection of pregnancy induced hypertension or intrauterine growth restriction

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.8249 ◽

2010 ◽

Vol 36 (S1) ◽

pp. 151-152

Author(s):

M. Odeh ◽

O. Maximovski ◽

V. Grinin ◽

E. Ophir ◽

J. Bornstein

Keyword(s):

Intrauterine Growth Restriction ◽

Power Doppler ◽

First Trimester ◽

Growth Restriction ◽

Pregnancy Induced Hypertension ◽

3 Dimensional ◽

Intrauterine Growth ◽

Induced Hypertension ◽

Placental Volume

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Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/1323891 ◽

2020 ◽

Vol 2020 ◽

pp. 1-12

Author(s):

Aleksandra Zygula ◽

Przemyslaw Kosinski ◽

Piotr Wroczynski ◽

Magdalena Makarewicz-Wujec ◽

Bronislawa Pietrzak ◽

...

Keyword(s):

Oxidative Stress ◽

Oral Health ◽

Oral Cavity ◽

Intrauterine Growth Restriction ◽

The State ◽

Growth Restriction ◽

Control Group ◽

Pregnancy Induced Hypertension ◽

Intrauterine Growth ◽

Induced Hypertension

Aim. Pregnancy-induced hypertension (PIH) and intrauterine growth restriction (IUGR) are both multisystemic disorders of pregnancy that cause perinatal morbidity and mortality. Recently, researchers focused on the role of oxidative stress (OS) as a pathophysiological mechanism in the development of these pathologies. The aim of this study was to compare OS in placental-related pathologies (PIH and IUGR) and uncomplicated pregnancies. We also investigated which salivary OS markers reflect systemic oxidative status and which only reflect the state of the oral cavity. Material and Methods. A total of 104 pregnant women (n=104; 27 with PIH, 30 with IUGR, and 47 controls) were evaluated. Malondialdehyde (MDA), total antioxidant capacity (ORAC), aldehyde dehydrogenase (ALDH), and activity of glutathione peroxidase (GPx) and glutathione transferase (GST) in plasma/whole blood and/or saliva were analysed. Dietary nutrient intake was calculated using a Semiquantitative Food Frequency Questionnaire (SFFQ). Oral health was assessed to eliminate patients with bleeding, severe periodontitis, and other dental pathologies. Results. In the IUGR group, increased concentration of ORAC was observed both in saliva and plasma. Also, lower plasma levels of MDA in IUGR compared to the control group was detected. No sign of oxidative stress was confirmed in the PIH group. The examined groups did not differ regarding diet and markers of inflammation. ORAC in saliva was correlated with its level in plasma. No such correlations for MDA were observed. In the IUGR group, there were no differences in OS markers in plasma, but there was a lower ALDH level in the blood compared to the control group. It confirms OS occurrence in IUGR. In IUGR, a higher activity of salivary ALDH was probably due to worse oral health. Conclusion. Oxidative stress differs between IUGR and PIH groups: the presence of oxidative stress was confirmed only in the IUGR group. Salivary ORAC can be used to estimate ORAC in plasma. The activity of salivary ALDH reflects the state of the oral cavity.

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