Ethanol toxicity in a dog due to gin‐soaked sloe berry ( Prunus spinosa ) ingestion

2021 ◽  
Author(s):  
Natalie West ◽  
Clare Rusbridge
Keyword(s):  
Prunus Spinosa ◽  
Ethanol Toxicity

Polysaccharides from the blackthorn gum (Prunus spinosa L.)

1966 ◽  
Vol 31 (8) ◽  
pp. 3410-3415 ◽  
Author(s):  
J. Rosík ◽  
M. Bruteničová-Sósková ◽  
V. Zitko ◽  
J. Kubala
Keyword(s):  
Prunus Spinosa

scholarly journals Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway

2017 ◽  
Vol 242 (10) ◽  
pp. 1025-1033 ◽  
Author(s):  
Weilong Chang ◽  
Jie Bai ◽  
Shaobo Tian ◽  
Muyuan Ma ◽  
Wei Li ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Epithelial Cells ◽  
Oxidative Damage ◽  
Signaling Pathway ◽  
Cell Damage ◽  
Mtor Signaling ◽  
Adaptive Mechanism ◽  
Mtor Signaling Pathway ◽  
Mucosal Epithelial Cell ◽  
Ethanol Toxicity

Alcohol abuse is an important cause of gastric mucosal epithelial cell injury and gastric ulcers. A number of studies have demonstrated that autophagy, an evolutionarily conserved cellular mechanism, has a protective effect on cell survival. However, it is not known whether autophagy can protect gastric mucosal epithelial cells against the toxic effects of ethanol. In the present study, gastric mucosal epithelial cells (GES-1 cells) and Wistar rats were treated with ethanol to detect the adaptive response of autophagy. Our results demonstrated that ethanol exposure induced gastric mucosal epithelial cell damage, which was accompanied by the downregulation of mTOR signaling pathway and activation of autophagy. Suppression of autophagy with pharmacological agents resulted in a significant increase of GES-1 cell apoptosis and gastric mucosa injury, suggesting that autophagy could protect cells from ethanol toxicity. Furthermore, we evaluated the cellular oxidative stress response following ethanol treatment and found that autophagy induced by ethanol inhibited generation of reactive oxygen species and degradation of antioxidant and lipid peroxidation. In conclusion, these findings provide evidence that ethanol can activate autophagy via downregulation of the mTOR signaling pathway, serving as an adaptive mechanism to ameliorate oxidative damage induced by ethanol in gastric mucosal epithelial cells. Therefore, modifying autophagy may provide a therapeutic strategy against alcoholic gastric mucosa injury. Impact statement The effect and mechanism of autophagy on ethanol-induced cell damage remain controversial. In this manuscript, we report the results of our study demonstrating that autophagy can protect gastric mucosal epithelial cells against ethanol toxicity in vitro and in vivo. We have shown that ethanol can activate autophagy via downregulation of the mTOR signaling pathway, serving as an adaptive mechanism to ameliorate ethanol-induced oxidative damage in gastric mucosal epithelial cells. This study brings new and important insights into the mechanism of alcoholic gastric mucosal injury and may provide an avenue for future therapeutic strategies.

SELECTION OF PRUNUS SPINOSA AS A DWARFING ROOTSTOCK FOR HIGH DENSITY PLUM ORCHARDS

2014 ◽  
pp. 507-516 ◽  
Author(s):  
F.M. Maas ◽  
J. Balkhoven-Baart ◽  
P.A.H. van der Steeg
Keyword(s):  
High Density ◽  
Prunus Spinosa ◽  
Selection Of

Phenolic Components and Antioxidant Activity of Prunus spinosa from Gumushane, Turkey

2015 ◽  
Vol 51 (2) ◽  
pp. 346-349 ◽  
Author(s):  
Rezzan Aliyazicioglu ◽  
Oktay Yildiz ◽  
Huseyin Sahin ◽  
Ozan Emre Eyupoglu ◽  
Mehtap Tugce Ozkan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Prunus Spinosa ◽  
Phenolic Components

Ethanol toxicity from mouthwash overingestion

2007 ◽  
Vol 52 (4) ◽  
pp. 245
Keyword(s):  
Ethanol Toxicity

Free Radical Mediated Reactions and Ethanol Toxicity: Some Considerations on the Methodological Approaches

Alcoholism ◽  
1991 ◽  
pp. 45-56 ◽  
Author(s):  
Emanuelle Albano ◽  
Magnus Ingelman-Sundberg ◽  
A. Tomasi ◽  
G. Poli
Keyword(s):  
Free Radical ◽  
Ethanol Toxicity ◽  
Methodological Approaches

scholarly journals Autophagy: A Sensor of Ethanol Toxicity in Various Body Organs

2013 ◽  
Vol 01 (04) ◽  
Author(s):  
Nabil Eid
Keyword(s):  
Ethanol Toxicity

scholarly journals Synchronisation of egg hatching of brown hairstreak (Thecla betulae) and budburst of blackthorn (Prunus spinosa) in a warmer future

2010 ◽  
Vol 15 (1-2) ◽  
pp. 311-319 ◽  
Author(s):  
H. H. de Vries ◽  
S. H. Ens ◽  
G. de Graaf ◽  
L. Teunissen ◽  
R. van der Velde ◽  
...  
Keyword(s):  
Egg Hatching ◽  
Prunus Spinosa

A New Model for Reducing Ethanol Toxicity

1980 ◽  
pp. 523-533
Author(s):  
V. P. de Lynch ◽  
S. J. Krebs ◽  
M. A. Dorato
Keyword(s):  
New Model ◽  
Ethanol Toxicity

The Metabolic Basis of Ethanol Toxicity

1973 ◽  
pp. 125-143 ◽  
Author(s):  
J. Tremolieres ◽  
R. Lowy ◽  
G. Griffaton
Keyword(s):  
Ethanol Toxicity ◽  
Metabolic Basis
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