scholarly journals Untargeted metabolomics approaches to improve casework in clinical and forensic toxicology—“Where are we standing and where are we heading?”

2021 ◽  
Author(s):  
Andrea Eva Steuer ◽  
Lana Brockbals ◽  
Thomas Kraemer
Keyword(s):  
Forensic Toxicology ◽  
Untargeted Metabolomics ◽  
Clinical And Forensic Toxicology

scholarly journals Applications of Metabolomics in Forensic Toxicology and Forensic Medicine

2021 ◽  
Vol 22 (6) ◽  
pp. 3010
Author(s):  
Michal Szeremeta ◽  
Karolina Pietrowska ◽  
Anna Niemcunowicz-Janica ◽  
Adam Kretowski ◽  
Michal Ciborowski
Keyword(s):  
Machine Learning ◽  
Multivariate Statistics ◽  
High Throughput ◽  
Forensic Medicine ◽  
Forensic Toxicology ◽  
Metabolic Changes ◽  
Untargeted Metabolomics ◽  
Criminal Cases ◽  
Statistical Approaches

Forensic toxicology and forensic medicine are unique among all other medical fields because of their essential legal impact, especially in civil and criminal cases. New high-throughput technologies, borrowed from chemistry and physics, have proven that metabolomics, the youngest of the “omics sciences”, could be one of the most powerful tools for monitoring changes in forensic disciplines. Metabolomics is a particular method that allows for the measurement of metabolic changes in a multicellular system using two different approaches: targeted and untargeted. Targeted studies are focused on a known number of defined metabolites. Untargeted metabolomics aims to capture all metabolites present in a sample. Different statistical approaches (e.g., uni- or multivariate statistics, machine learning) can be applied to extract useful and important information in both cases. This review aims to describe the role of metabolomics in forensic toxicology and in forensic medicine.

Some typical applications of gc-ms in clinical and forensic toxicology

1975 ◽  
Vol 5 (2) ◽  
pp. 147
Author(s):  
J.G. Leferink ◽  
R.A.A. Maes ◽  
I. Sunshine ◽  
B. Forney
Keyword(s):  
Forensic Toxicology ◽  
Clinical And Forensic Toxicology

scholarly journals Hyphenated high-resolution mass spectrometry—the “all-in-one” device in analytical toxicology?

2020 ◽  
Author(s):  
Hans H. Maurer
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Forensic Toxicology ◽  
Analytical Toxicology ◽  
High Resolution Mass ◽  
Scientific Meetings ◽  
Application Fields ◽  
Clinical And Forensic Toxicology ◽  
Resolution Mass

AbstractThis trend article reviews papers with hyphenated high-resolution mass spectrometry (HRMS) approaches applied in analytical toxicology, particularly in clinical and forensic toxicology published since 2016 and referenced in PubMed. The article focuses on the question of whether HRMS has or will become the all-in-one device in these fields as supposed by the increasing number of HRMS presentations at scientific meetings, corresponding original papers, and review articles. Typical examples for the different application fields are discussed such as targeted or untargeted drug screening, quantification, drug metabolism studies, and metabolomics approaches. Considering the reviewed papers, HRMS is currently the only technique that fulfills the criteria of an all-in-one device for the various applications needed in analytical toxicology.Graphical abstract

Multiple stage MS in analysis of plasma, serum, urine andin vitrosamples relevant to clinical and forensic toxicology

Bioanalysis ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 457-481 ◽  
Author(s):  
Golo M Meyer ◽  
Hans H Maurer ◽  
Markus R Meyer
Keyword(s):  
Forensic Toxicology ◽  
Clinical And Forensic Toxicology
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