scholarly journals Association of FMRP with Ribosomal Precursor Particles in the Nucleolus

1996 ◽  
Vol 225 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Rob Willemsen ◽  
Carola Bontekoe ◽  
Filippo Tamanini ◽  
Hans Galjaard ◽  
Andre Hoogeveen ◽  
...  
Keyword(s):  
Ribosomal Precursor

Control points in eucaryotic ribosome biogenesis

1991 ◽  
Vol 69 (1) ◽  
pp. 5-22 ◽  
Author(s):  
D. E. Larson ◽  
P. Zahradka ◽  
B. H. Sells
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Ribosomal Proteins ◽  
Ribosome Biogenesis ◽  
Rna Polymerase Iii ◽  
Ribosomal Subunits ◽  
Rrna Species ◽  
Polymerase I ◽  
Ribosomal Precursor ◽  
Precursor Molecules

Ribosome biogenesis in eucaryotic cells involves the coordinated synthesis of four rRNA species, transcribed by RNA polymerase I (18S, 28S, 5.8S) and RNA polymerase III (5S), and approximately 80 ribosomal proteins translated from mRNAs synthesized by RNA polymerase II. Assembly of the ribosomal subunits in the nucleolus, the site of 45S rRNA precursor gene transcription, requires the movement of 5S rRNA and ribosomal proteins from the nucleoplasm and cytoplasm, respectively, to this structure. To integrate these events and ensure the balanced production of individual ribosomal components, different strategies have been developed by eucaryotic organisms in response to a variety of physiological changes. This review presents an overview of the mechanisms modulating the production of ribosomal precursor molecules and the rate of ribosome biogenesis in various biological systems.Key words: rRNA, ribosomal proteins, nucleolus, ribosome.

Ribosomal precursor particles in ascites tumor cell nucleoli

1973 ◽  
Vol 81 (1) ◽  
pp. 1-7 ◽  
Author(s):  
R. Simard ◽  
Françoise Sakr ◽  
J.-P. Bachellerie
Keyword(s):  
Tumor Cell ◽  
Ascites Tumor ◽  
Ribosomal Precursor

Effect of Cordycepin on Ribosome Formation and Enzyme Induction in Rat Liver

1972 ◽  
Vol 50 (9) ◽  
pp. 1010-1015 ◽  
Author(s):  
Arthur J. Rizzo ◽  
Camille Kelly ◽  
Thomas E. Webb
Keyword(s):  
Rat Liver ◽  
Messenger Rna ◽  
Nucleocytoplasmic Transport ◽  
Current Theory ◽  
Polyadenylic Acid ◽  
General Protein Synthesis ◽  
Tyrosine Transaminase ◽  
General Protein ◽  
Nuclear Processing ◽  
Ribosomal Precursor

Cordycepin (3′-deoxyadenosine), at a dose of 10 mg/kg, inhibits the accumulation of ribosomes in rat liver cytoplasm within 2.5 h of administration. This effect is not due to an inhibition of RNA synthesis per se but rather to the premature termination of the transcription of the 45 S ribosomal precursor in the presence of the analogue. The nucleoside analogue also inhibits the corticosteroid-mediated induction of tyrosine transaminase and general protein synthesis. The latter results are consistent with the current theory that cordycepin inhibits the formation of polyadenylic acid which is involved in the nuclear processing and/or nucleocytoplasmic transport of messenger RNA.

Ribosomal precursor 3′ end formation requires a conserved element upstream of the promoter

Cell ◽  
1987 ◽  
Vol 50 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Paul Labhart ◽  
Ronald H. Reeder
Keyword(s):  
Ribosomal Precursor
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