Chemically Modified Tetracyclines Inhibit Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Cultured Rat Mesangial Cells

1996 ◽  
Vol 229 (1) ◽  
pp. 243-248 ◽  
Author(s):  
Howard Trachtman ◽  
Stephen Futterweit ◽  
Robert Greenwald ◽  
Susan Moak ◽  
Pravin Singhal ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Mesangial Cells ◽  
Nitric Oxide Production ◽  
Chemically Modified ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Chemically Modified Tetracyclines ◽  
Inducible Nitric Oxide

scholarly journals Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase.

1995 ◽  
Vol 181 (1) ◽  
pp. 63-70 ◽  
Author(s):  
N K Worrall ◽  
W D Lazenby ◽  
T P Misko ◽  
T S Lin ◽  
C P Rodi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Immune Response ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Biologically Active ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

The role of nitric oxide in the immune response to allogeneic tissue was explored in an in vivo cardiac transplant model in the rat. Nitric oxide production during organ rejection was demonstrated by elevations in systemic serum nitrite/nitrate levels and by electron paramagnetic resonance spectroscopy. Messenger RNA for the inducible nitric oxide synthase enzyme was detected in the rejecting allografted heart, but not in the nonrejecting isografted heart. The enzyme was demonstrated to be biologically active by the in vitro conversion of L-arginine to L-citrulline and was immunohistochemically localized to the infiltrating inflammatory cells. Treatment with aminoguanidine, a preferential inhibitor of the inducible nitric oxide synthase isoform, prevented the increased nitric oxide production in the transplanted organ and significantly attenuated the pathogenesis of acute rejection. Aminoguanidine treatment prolonged graft survival, improved graft contractile function, and significantly reduced the histologic grade of rejection. These results suggest an important role for nitric oxide in mediating the immune response to allogeneic tissue. Inhibition of inducible nitric oxide synthase may provide a novel therapeutic modality in the management of acute transplant rejection and of other immune-mediated processes.

Melatonin inhibits visfatin-induced inducible nitric oxide synthase expression and nitric oxide production in macrophages

2013 ◽  
Vol 55 (3) ◽  
pp. 294-303 ◽  
Author(s):  
Young-Soon Kang ◽  
Yong-Gyu Kang ◽  
Hyun-Joo Park ◽  
Hee-Jun Wee ◽  
Hye-Ock Jang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion

2001 ◽  
Vol 33 (3) ◽  
pp. 579-586 ◽  
Author(s):  
Jason M. Johanning ◽  
David P. Franklin ◽  
David C. Han ◽  
David J. Carey ◽  
James R. Elmore
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Nitric Oxide Production ◽  
Experimental Aneurysm ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

HIV-1 induced decrease of nitric oxide production and inducible nitric oxide synthase expression during in vivo and in vitro infection

2008 ◽  
Vol 127 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Ernesto Cairoli ◽  
Daniel Scott-Algara ◽  
Otto Pritsch ◽  
Guillermo Dighiero ◽  
Alfonso Cayota
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Oxide Synthase ◽  
Hiv 1 ◽  
Inducible Nitric Oxide
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