The Formation of Oxidatively Induced High-Molecular-Weight Aggregate of α-/γ-Crystallins

1999 ◽  
Vol 260 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Fu-Yung Huang ◽  
Chin-Min Chia ◽  
Yuh Ho
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
High Molecular Weight Aggregate

scholarly journals Studies on the assembly of the rat lens capsule. Biosynthesis of a cross-linked collagenous component of high molecular weight

1980 ◽  
Vol 190 (2) ◽  
pp. 229-237 ◽  
Author(s):  
J G Heathcote ◽  
A J Bailey ◽  
M E Grant
Keyword(s):  
Molecular Weight ◽  
Tissue Culture ◽  
High Molecular Weight ◽  
Lens Capsule ◽  
Cross Link ◽  
Membrane Matrix ◽  
Cross Links ◽  
High Molecular Weight Aggregate

1. Intact rat lenses in tissue culture synthesize hydroxy[3H]proline-containing polypeptides of apparent mol.wt. approx. 180000, which become assembled into aggregates of higher molecular weight with time. 2. Both the 180000-mol.wt. species and the aggregates are components of the deoxycholate-insoluble base-membrane matrix. 3. Formation of the high-molecular-weight aggregate is accompanied by the biosynthesis of the reducible hydroxylysine-derived cross-link hydroxylysino-5-oxo-norleucine. 4. Hydroxylysino-5-oxonorleucine and dehydrohydroxylysinonorleucine are the major reducible cross-links present in intact foetal and 1-month-old calf lens capsules.

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