Accumulation of Immature CD3-CD4+CD8- Single-Positive Cells That Lack CD69 in Epithelial Cell Tumors of the Human Thymus

1995 ◽  
Vol 161 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Yukiyasu Takeuchi ◽  
Yoshitaka Fujii ◽  
Meinoshin Okumura ◽  
Keiji Inada ◽  
Kazuya Nakahara ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Human Thymus ◽  
Single Positive

Characterization of CD4+ Single Positive Cells That Lack CD3 in the Human Thymus

1993 ◽  
Vol 151 (2) ◽  
pp. 481-490 ◽  
Author(s):  
Yukiyasu Takeuchi ◽  
Yoshitaka Fujii ◽  
Meinoshin Okumura ◽  
Keiji Inada ◽  
Kazuya Nakahara ◽  
...  
Keyword(s):  
Human Thymus ◽  
Single Positive

Mature CD4 Single Positive Thymocytes in Human Thymoma: T Cells May Differentiate in the Thymic Epithelial Cell Tumor

Pathobiology ◽  
1997 ◽  
Vol 65 (4) ◽  
pp. 216-222 ◽  
Author(s):  
Masayoshi Inoue ◽  
Yoshitaka Fujii ◽  
Meinoshin Okumura ◽  
Yukiyasu Takeuchi ◽  
Hiroyuki Shiono ◽  
...  
Keyword(s):  
T Cells ◽  
Epithelial Cell ◽  
Cell Tumor ◽  
Thymic Epithelial Cell ◽  
Single Positive

Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) αβ+CD8+ single-positive T cells, TCRγδ+ T cells, and natural killer–type cells in human thymus

Blood ◽  
2001 ◽  
Vol 97 (3) ◽  
pp. 601-607 ◽  
Author(s):  
Paola Romagnani ◽  
Francesco Annunziato ◽  
Elena Lazzeri ◽  
Lorenzo Cosmi ◽  
Chiara Beltrame ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Natural Killer ◽  
T Cell Receptor ◽  
Interferon Gamma ◽  
Cell Receptor ◽  
Human Thymus ◽  
Single Positive ◽  
Inducible Protein ◽  
Interferon Inducible Protein

Abstract Strong reactivity for interferon-inducible protein 10 (IP-10), monokine induced by interferon gamma (Mig), and interferon-inducible T-cell alpha chemoattractant (I-TAC) was found in epithelial cells mainly localized to the medulla of postnatal human thymus. The CXC chemokine receptor common to the 3 chemokines (CXCR3) was also preferentially expressed in medullary areas of the same thymuses and appeared to be a property of 4 distinct populations: CD3+T-cell receptor (TCR) αβ+CD8+ single-positive (SP) T cells, TCRγδ+ T cells, natural killer (NK)–type cells, and a small subset of CD3+(low)CD4+CD8+TCRαβ+double-positive (DP) T cells. IP-10, Mig, and I-TAC showed chemoattractant activity for TCRαβ+CD8+ SP T cells, TCRγδ+ T cells, and NK-type cells, suggesting their role in the migration of different subsets of mature thymocytes during human thymus lymphopoiesis.

scholarly journals Detection of growth hormone-producing cells in human thymus by immunohistochemistry and non-radioactive in situ hybridization.

1994 ◽  
Vol 42 (10) ◽  
pp. 1349-1354 ◽  
Author(s):  
N Maggiano ◽  
M Piantelli ◽  
R Ricci ◽  
L M Larocca ◽  
A Capelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Transcription Factor ◽  
In Situ Hybridization ◽  
Epithelial Cell ◽  
T Lymphocyte ◽  
Lymphoid Cells ◽  
Thymus Gland ◽  
Local Concentration ◽  
Human Thymus

It is well recognized that growth hormone (GH) may act as a growth and differentiation factor for the thymus gland. Recently, it has been reported that Pit-1/GHF-1 transcription factor, which controls the expression of both GH and prolactin, is expressed in stromal (not lymphoid) cells of human thymus. Here, we demonstrated by immunohistochemistry and in situ hybridization the presence of distinct GH-producing epithelial cell subsets in human thymus. The cells positive for GH mRNA and GH-immunoreactive substance are both located in the same thymus compartments, i.e., along the thymus capsule, in the subcapsular cortex, and within the septa. Local concentration of GH higher than systemic ones, in combination with other factors, may be important in regulating the thymic microenvironment necessary for T-lymphocyte differentiation.

Heterogeneity of Human Thymus Epithelial Cells Revealed by Monoclonal Anti-Epithelial Cell Antibodies

1985 ◽  
pp. 283-288
Author(s):  
Mary A. Ritter ◽  
Henk-Jan Schuurman ◽  
Wilma A. MacKenzie ◽  
Ruud A. de Maagd ◽  
Kevin M. Price ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Epithelial Cells ◽  
Human Thymus ◽  
Thymus Epithelial Cells

Inefficient Positive Selection of CD4+ T Cells in Epithelial Cell Tumors of the Human Thymus

1997 ◽  
pp. 157-164
Author(s):  
Yukiyasu Takeuchi ◽  
Yoshitaka Fujii ◽  
Meinoshin Okumura ◽  
Hikaru Matsuda
Keyword(s):  
T Cells ◽  
Epithelial Cell ◽  
Positive Selection ◽  
Cd4 T Cells ◽  
Human Thymus ◽  
Selection Of

scholarly journals Immunoreactive neuropeptides in the cells of human thymus

2011 ◽  
Vol 63 (4) ◽  
pp. 971-977
Author(s):  
Gordana Leposavic ◽  
Vera Todorovic ◽  
I. Nikolic ◽  
Milica Perisic
Keyword(s):  
Epithelial Cell ◽  
Substance P ◽  
Epithelial Cells ◽  
Vasoactive Intestinal Peptide ◽  
Immunohistochemical Staining ◽  
Lymphoid Cells ◽  
Cell Network ◽  
Human Thymus ◽  
Corticomedullary Junction ◽  
Calcitonin Gene

The study was designed to explore the expression of different neuropeptides, viz. vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP), bombesin and motilin in the cells of fetal and adult human thymus. Immunohistochemical staining revealed that cortical and medullary thymocytes were labeled by all antibodies, except those specific for motilin. Immunoreactive VIP and SP were observed in the solitary epithelial cells located in the subcapsular/subtrabecular cortex, at the corticomedullary junction and in the medulla. The cells within the subcapsular/subtrabecular monolayer, rare solitary cells in the deep cortex and epithelial cell network in the medulla, were labeled with antibodies to CGRP and bombesin. Hassall?s corpuscles were labeled with all antibodies except that specific for SP. The obtained data obtained testify to the expression of different neuropeptides in human thymic lymphoid and non-lymphoid cells and suggest a role for neuroendocrine hormone-mediated mechanisms in the regulation of thymic homeostasis in humans.

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