Importance of Balance between Extracellular Matrix Synthesis and Degradation in Basement Membrane Formation

2001 ◽  
Vol 271 (2) ◽  
pp. 249-262 ◽  
Author(s):  
Satoshi Amano ◽  
Nobuko Akutsu ◽  
Yukiko Matsunaga ◽  
Kuniko Kadoya ◽  
Toshio Nishiyama ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Basement Membrane ◽  
Matrix Synthesis ◽  
Membrane Formation ◽  
Synthesis And Degradation

scholarly journals Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3‐E1 osteoblasts in vitro

2001 ◽  
Vol 16 (3) ◽  
pp. 500-505 ◽  
Author(s):  
Alessia Fornoni ◽  
Flavia Cornacchia ◽  
Guy A. Howard ◽  
Bernard A. Roos ◽  
Gary E. Striker ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cyclosporin A ◽  
Matrix Synthesis ◽  
Synthesis And Degradation

Imbalance in Extracellular Matrix Synthesis and Degradation as a Mechanism of Leaflet Weakening in Sporadic Mitral Valve Prolapse in Humans

2012 ◽  
Vol 2012 (4) ◽  
pp. 84
Author(s):  
Samiya Hussain ◽  
Bryant V. McIver ◽  
Lexis Neill ◽  
Kim Biao ◽  
John D. Puskas ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Matrix Synthesis ◽  
Synthesis And Degradation

Extracellular matrix synthesis by coal dust-exposed type II epithelial cells

1994 ◽  
Vol 267 (4) ◽  
pp. L365-L374
Author(s):  
Y. C. Lee ◽  
R. Hogg ◽  
D. E. Rannels
Keyword(s):  
Extracellular Matrix ◽  
Basement Membrane ◽  
Coal Dust ◽  
Alveolar Epithelium ◽  
Dust Exposure ◽  
Type Ii ◽  
Direct Effects ◽  
Matrix Synthesis ◽  
Ecm Proteins ◽  
Dose Dependent

Although integrity of the alveolar basement membrane may influence progression of lung injury induced by inhaled particulates, little is known about direct effects of coal dusts on the alveolar epithelium or its extracellular matrix (ECM). Effects of dust on synthesis of cell and ECM proteins by type II cells (T2P) was thus investigated. Three coal dusts (anthracite no. 867; bituminous no. 1451 and no. 1361) and mine dust MIT-3, of respirable size, were studied as a function of dose and time over 3 days of primary T2P culture. On day 1, 750 micrograms/ml of 867 were required to increase relative synthesis of ECM proteins (ECM/cell). MIT-3, 1451, and 1361 were without effect. By day 3, 867 or MIT-3 increased ECM/cell 60-100% at 300 micrograms/ml; 1451 produced modest, dose-dependent stimulation, whereas 1361 remained without effect. None of the dusts caused significant cytotoxicity. The results show dose- and time-dependent effects of well-characterized coal and mind dusts to modify partitioning of newly synthesized proteins into the ECM and suggest that coal dust exposure may modulate structure or function of the subepithelial basement membrane.

Cardiac myocytes cultured on a basement membrane extract of the ehs tumor

1986 ◽  
Vol 44 ◽  
pp. 270-271
Author(s):  
L. Terracio ◽  
A. Dewey ◽  
K. Rubin ◽  
T.K. Borg
Keyword(s):  
Extracellular Matrix ◽  
Basement Membrane ◽  
Cardiac Myocytes ◽  
Normal Tissue ◽  
Cell Spreading ◽  
Collagen Iv ◽  
Basement Membrane Extract ◽  
Membrane Extract ◽  
Growth Development ◽  
Multicellular Organisms

The recognition and interaction of cells with the extracellular matrix (ECM) effects the normal physiology as well as the pathology of all multicellular organisms. These interactions have been shown to influence the growth, development, and maintenance of normal tissue function. In previous studies, we have shown that neonatal cardiac myocytes specifically interacts with a variety of ECM components including fibronectin, laminin, and collagens I, III and IV. Culturing neonatal myocytes on laminin and collagen IV induces an increased rate of both cell spreading and sarcomerogenesis.

Exploiting Stem Cell-Extracellular Matrix Interactions for Cartilage Regeneration: A Focus on Basement Membrane Molecules

2016 ◽  
Vol 11 (8) ◽  
pp. 618-625 ◽  
Author(s):  
Wei Seong Toh ◽  
Casper Bindzus Foldager ◽  
James Hoi Po Hui ◽  
Bjorn Reino Olsen ◽  
Myron Spector
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Basement Membrane ◽  
Cartilage Regeneration ◽  
Matrix Interactions ◽  
Extracellular Matrix Interactions

scholarly journals Extracellular matrix synthesis by skeletal muscle in culture. Proteins and effect of enzyme degradation.

1982 ◽  
Vol 257 (19) ◽  
pp. 11437-11442
Author(s):  
R L Beach ◽  
W V Burton ◽  
W J Hendricks ◽  
B W Festoff
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Matrix Synthesis ◽  
Enzyme Degradation
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