Extent and Duration of Recovered Pupillary Light Reflex Following Retinal Ganglion Cell Axon Regeneration through Peripheral Nerve Grafts Directed to the Pretectum in Adult Rats

1998 ◽  
Vol 154 (2) ◽  
pp. 560-572 ◽  
Author(s):  
S.J.O. Whiteley ◽  
Y. Sauvé ◽  
M. Avilés-Trigueros ◽  
M. Vidal-Sanz ◽  
R.D. Lund
Keyword(s):  
Peripheral Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Nerve Grafts ◽  
Pupillary Light ◽  
Peripheral Nerve Grafts ◽  
Ganglion Cell Axon

scholarly journals The use of peripheral nerve grafts to enhance neuronal survival, promote growth and permit terminal reconnections in the central nervous system of adult rats

1987 ◽  
Vol 132 (1) ◽  
pp. 5-19 ◽  
Author(s):  
G. M. Bray ◽  
M. P. Villegas-Perez ◽  
M. Vidal-Sanz ◽  
A. J. Aguayo
Keyword(s):  
Peripheral Nerve ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Term Survival ◽  
Nerve Grafts ◽  
Cells Of Origin ◽  
Peripheral Nerve Grafts ◽  
The Central Nervous System

During both development and regeneration, the survival of neurones and the growth of axons are controlled by inherent neuronal properties, conditions in the axonal environment, and the establishment of appropriately timed and specific functional contacts. To study the effects of extrinsic influences on the survival, growth and connectivity of axotomized neurones in the mature mammalian CNS, we replaced the optic nerve in adult rats with segments of autologous peripheral nerve (PN) and used morphometric techniques, neuroanatomical tracer substances and immunological cell markers to examine retinal ganglion cells (RGCs), their axons in the PN grafts and their terminals in the superior colliculi (SC) of these animals. We observed that: (1) the survival of axotomized RGCs was enhanced by the PN grafts; (2) in the PN-grafted eyes, approximately 20% of the surviving RGCs regrew their axons into the grafts and (3) some of the RGC axons that regenerated along the PN grafts bridging the eye and the tectum re-entered the SC, arborized and made synaptic contacts with tectal neurones. It is not known if the terminal connections established between RGCs and cells in the SC are appropriate, functional or capable of influencing the long-term survival of their cells of origin.

Retinal Ganglion Cell Axon Regeneration Requires Complement and Myeloid Cell Activity within the Optic Nerve

2021 ◽  
pp. JN-RM-0555-21
Author(s):  
Sheri L. Peterson ◽  
Yiqing Li ◽  
Christina J. Sun ◽  
Kimberly A. Wong ◽  
Kylie S. Leung ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Axon Regeneration ◽  
Cell Activity ◽  
Myeloid Cell ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
Ganglion Cell Axon
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