Activated (HLA-DR+) T-Lymphocyte Subsets in Early Epithelial Ovarian Cancer and Malignant Ovarian Germ Cell Tumors

1995 ◽  
Vol 58 (3) ◽  
pp. 362-367 ◽  
Author(s):  
K. Miyazaki ◽  
K. Shimada ◽  
H. Katabuchi ◽  
F. Arakane ◽  
S. Arao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Germ Cell ◽  
Epithelial Ovarian Cancer ◽  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
Germ Cell Tumors ◽  
T Lymphocyte Subsets ◽  
Hla Dr

Non-Epithelial Ovarian Cancer; NCI Study

2020 ◽  
Vol 106 (1_suppl) ◽  
pp. 7-7
Author(s):  
Ashraf Sobhy ◽  
Mohammed Gamil ◽  
Omar Youssef ◽  
Ali Hassan Mebed
Keyword(s):  
Ovarian Cancer ◽  
Germ Cell ◽  
Epithelial Ovarian Cancer ◽  
Germ Cell Tumors ◽  
Disease Stage ◽  
Early Stage Disease ◽  
Stromal Tumors ◽  
Ovarian Cancers ◽  
Malignant Germ Cell Tumors ◽  
Sex Cord Stromal Tumors

Background: Non-epithelial cancers of the ovary are uncommon. They include malignancies of germ cell origin, sex cord-stromal cell origin, metastatic carcinomas to the ovary, and a variety of extremely rare ovarian cancers, such as sarcomas and lipoid cell tumors. Nonepithelial malignancies account for about 10% of all ovarian cancers. Objective: To review the management of Non-epithelial ovarian cancer in the NCI Cairo university during a period of 5 years (2005 till 2010). Material and Methods: Retrospective study including 114 patients who were diagnosed and treated with Non-epithelial ovarian cancer (2005 to 2010). Data were collected from the biostatistics and cancer epidemiology department. Results: Out of 114 patients; 25(21.9%) were benign and 25 (21.9%) were borderline malignant; 55 (48.2%) were malignant and 9 (7.89%) of them were unpredicted biologic behavior; the median age of the study population was 49.7 years (range 14_83years). Panhysterectomy was done in 77(67.5%) of the patients; ovariectomy and debulking were done in 22(19.3%; salpingooophorectomy was done in 10(8.8%) 0f patients and cystectomy was done in 3(2.6%) and 2 cases underwent biopsy. Conclusion: Sex cord-stromal tumors and malignant germ cell tumors are the most common nonepithelial ovarian cancers. These tumors often, but not always, present with the sequelae of overproduction of either androgens or estrogens. It is important to diagnose these masses early, as overall prognosis is typically very good for early stage disease in all histological subtypes. Both sex cord-stromal tumors and malignant germ cell tumors of the ovary are treated with initial surgical resection. Fertility sparing surgery can be considered for both sex cord-stromal and malignant germ cell tumors of the ovary. Depending on the pathological diagnosis and disease stage, postoperative management consists of either expectant management or adjuvant chemotherapy. It is recommended that all patients with nonepithelial ovarian cancer be monitored for evidence of disease recurrence on a standardized schedule.

Immunopathological patterns in the rectal mucosa of patients with shigellosis: expression of HLA-DR antigens and T-lymphocyte subsets

Apmis ◽  
1994 ◽  
Vol 102 (1-6) ◽  
pp. 371-380 ◽  
Author(s):  
RUBHANA Raqib ◽  
FINN P. Reinholt ◽  
PRADEEP KUMAR Bardhan ◽  
ANDERS KÄRnell ◽  
ALF A. Lindberg
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
Rectal Mucosa ◽  
T Lymphocyte Subsets ◽  
Hla Dr

scholarly journals Immunologic Monitoring of T-Lymphocyte Subsets and HLA-DR-Positive Monocytes in Kidney Transplant Recipients

Medicine ◽  
2015 ◽  
Vol 94 (44) ◽  
pp. e1902 ◽  
Author(s):  
Jang-Hee Cho ◽  
Young-Deuk Yoon ◽  
Hye Min Jang ◽  
Eugene Kwon ◽  
Hee-Yeon Jung ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
T Lymphocyte Subsets ◽  
Hla Dr ◽  
Immunologic Monitoring

Activated (HLA-DR+) T-Lymphocyte Subsets in Cervical Carcinoma and Effects of Radiotherapy and Immunotherapy with Sizofiran on Cell-Mediated Immunity and Survival

1995 ◽  
Vol 56 (3) ◽  
pp. 412-420 ◽  
Author(s):  
Kohji Miyazaki ◽  
Hiroshi Mizutani ◽  
Hidetaka Katabuchi ◽  
Keizo Fukuma ◽  
Shunichi Fujisaka ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
Cell Mediated Immunity ◽  
T Lymphocyte Subsets ◽  
Hla Dr

T-Lymphocyte Subsets and HLA-DR-Expressing Cells in the Osteoarthritic Synovialis

1985 ◽  
Vol 14 (3) ◽  
pp. 259-264 ◽  
Author(s):  
Olof Johnell ◽  
Anders Hulth ◽  
Anders Henricson
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
T Lymphocyte Subsets ◽  
Hla Dr

Factors associated with non-epithelial ovarian cancer among Mexican women: A matched case-control study

2003 ◽  
Vol 13 (6) ◽  
pp. 756-763
Author(s):  
L. M. Sanchez-Zamorano ◽  
E. Salazar-Martinez ◽  
P. Escudero-De Los Rios ◽  
G. Gonzalez-Lira ◽  
L. Flores-Luna ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Germ Cell ◽  
Epithelial Ovarian Cancer ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Full Term ◽  
Mexican Women ◽  
Factors Associated ◽  
Control Study

The purpose of this study was to identify risk factors associated with the development of non-epithelial ovarian cancer in Mexican women. A case-control study was carried out on women registered with the Mexican Institute of Social Security in Mexico City over a period of two years (1995–97). Twenty-eight new cases were recruited from the Gynecology and Obstetrics Hospital no. 4, “Luis Castelazo Ayala”, and were matched by age with 84 controls selected randomly. Eighteen (64.3%) cases of germ cell tumors and 10 (35.7%) stromal sex cord tumors were found. The number of full term pregnancies was associated inversely to development of stromal sex cord tumors with lower risk in women with more than three full term pregnancies (odds ratio, 0.02: 95% confidence interval, 0.001–0.56) compared to nulliparous women. No associations were found respecting to germ cell tumors. Parity was inversely associated to development of stromal sex cord tumors, probably as a result of the endocrine system's influence on the ovaries. The development of germ cell tumors could be associated to factors not evaluated in this study.

scholarly journals Application of immunoelectron microscopy for identification of T lymphocyte subsets and HLA DR antigen positive cells in tissue.

1984 ◽  
Vol 32 (5) ◽  
pp. 547-551 ◽  
Author(s):  
H P Dienes ◽  
K Essling ◽  
H D John
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
Suppressor Cells ◽  
T Cell Subsets ◽  
Electron Microscopic Level ◽  
Electron Microscopic ◽  
T Lymphocyte Subsets ◽  
Minimal Loss ◽  
Hla Dr ◽  
Cryostat Sections

The identification of T lymphocyte subsets by means of monoclonal antisera in tissue has so far been restricted to light microscopic observations on cryostat sections, since the conventional fixatives as formaldehyde, B5, or glutaraldehyde seem to denature the surface antigens. Applying a mild fixative, periodate-lysine-paraformaldehyde (PLP), we were able to demonstrate T cell subsets on the electron microscopic level in human tonsils with minimal loss of antigenicity of the surface markers Leu 1, OKT4, OKT8, and HLA DR. The preservation of the tissue could be compared favorably to fixation with glutaraldehyde, and provided an ultrastructural basis to distinguish helper and suppressor cells by morphological features as well.

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