Factors associated with non-epithelial ovarian cancer among Mexican women: A matched case-control study

The purpose of this study was to identify risk factors associated with the development of non-epithelial ovarian cancer in Mexican women. A case-control study was carried out on women registered with the Mexican Institute of Social Security in Mexico City over a period of two years (1995–97). Twenty-eight new cases were recruited from the Gynecology and Obstetrics Hospital no. 4, “Luis Castelazo Ayala”, and were matched by age with 84 controls selected randomly. Eighteen (64.3%) cases of germ cell tumors and 10 (35.7%) stromal sex cord tumors were found. The number of full term pregnancies was associated inversely to development of stromal sex cord tumors with lower risk in women with more than three full term pregnancies (odds ratio, 0.02: 95% confidence interval, 0.001–0.56) compared to nulliparous women. No associations were found respecting to germ cell tumors. Parity was inversely associated to development of stromal sex cord tumors, probably as a result of the endocrine system's influence on the ovaries. The development of germ cell tumors could be associated to factors not evaluated in this study.

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Factors associated with non-epithelial ovarian cancer among Mexican women: A matched case-control study

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2003.13604.x ◽

2003 ◽

Vol 13 (6) ◽

pp. 756-763 ◽

Cited By ~ 3

Author(s):

L. M. Sanchez-Zamorano ◽

E. Salazar-Martinez ◽

P. Escudero- De Los Rios ◽

G. Gonzalez-Lira ◽

L. Flores-Luna ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Case Control Study ◽

Case Control ◽

Mexican Women ◽

Factors Associated ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

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Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016

Cancer Causes & Control ◽

10.1007/s10552-021-01434-0 ◽

2021 ◽

Author(s):

Clinton Hall ◽

Johnni Hansen ◽

Jørn Olsen ◽

Di He ◽

Ondine S. von Ehrenstein ◽

...

Keyword(s):

Germ Cell ◽

Maternal Employment ◽

Case Control Study ◽

Germ Cell Tumors ◽

Social Contact ◽

Case Control ◽

Yolk Sac ◽

Parental Occupation ◽

Yolk Sac Tumors ◽

Control Study

Abstract Purpose To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). Methods This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). Results Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95). Conclusion Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors.

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