Nitric Oxide Contributes to Adriamycin's Antitumor Effect

1997 ◽  
Vol 69 (2) ◽  
pp. 283-287 ◽  
Author(s):  
D.Scott Lind ◽  
Maria I. Kontaridis ◽  
Paul D. Edwards ◽  
Michael D. Josephs ◽  
Lyle L. Moldawer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antitumor Effect

Chemical Insights in the Concept of Hybrid Drugs:  The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin

2007 ◽  
Vol 50 (10) ◽  
pp. 2424-2431 ◽  
Author(s):  
Niels Hulsman ◽  
Jan Paul Medema ◽  
Carina Bos ◽  
Aldo Jongejan ◽  
Rob Leurs ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antitumor Effect ◽  
Quinone Methide ◽  
Hybrid Drugs

Nitric oxide inhibition, antioxidant, and antitumour activities of novel copper(ii) bis-benzimidazole diamide nanocoordination complexes

2015 ◽  
Vol 39 (6) ◽  
pp. 4316-4327 ◽  
Author(s):  
Manisha Singla ◽  
Rajeev Ranjan ◽  
Kuldeep Mahiya ◽  
Subash C. Mohapatra ◽  
Sharif Ahmad
Keyword(s):  
Nitric Oxide ◽  
Body Weight ◽  
Antitumor Effect ◽  
Nitric Oxide Inhibition ◽  
Weight Difference ◽  
Body Weight Difference ◽  
Oxide Inhibition

Antitumor effect illustrated by changes in body weight. In control mice, body weight increased to 11.5 g but when treated withC3, body weight difference as compared to the control decreased by 4.7 g and decreased to 2.2 g and 0.6 g withC1andC2, respectively.

ANTITUMOR EFFECT OF NITRIC OXIDE (NO) DONORS AND MECHANISMS OF ITS IMPLEMENTATION

2021 ◽  
Author(s):  
Valentina Petrovna Deryagina ◽  
◽  
Natalia Ilyinichna Ryzhova ◽  
Lyudmila Savluchinskaya ◽  
Leila Vladimirovna Krivosheeva ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antitumor Effect ◽  
No Donors ◽  
Oncogenic Pathways ◽  
Antitumor Potential ◽  
Cytotoxic Compounds

The review discusses literature data and the results of our own studies on the role of nitric oxide in carcinogenesis. The antitumor potential of classical NO donors as cytotoxic compounds and modulators of signaling oncogenic pathways is analyzed.

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

Nitric Oxide Reduces Pressor Responsiveness During Ovine Hypoadrenocorticism

2001 ◽  
Vol 28 (5-6) ◽  
pp. 459-462
Author(s):  
Pini Orbach ◽  
Charles E Wood ◽  
Maureen Keller-Wood
Keyword(s):  
Nitric Oxide
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