Faculty Opinions recommendation of Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin.

2007 ◽  
Author(s):  
David Triggle
Keyword(s):  
Nitric Oxide ◽  
Antitumor Effect ◽  
Quinone Methide ◽  
Hybrid Drugs

Chemical Insights in the Concept of Hybrid Drugs:  The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin

2007 ◽  
Vol 50 (10) ◽  
pp. 2424-2431 ◽  
Author(s):  
Niels Hulsman ◽  
Jan Paul Medema ◽  
Carina Bos ◽  
Aldo Jongejan ◽  
Rob Leurs ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antitumor Effect ◽  
Quinone Methide ◽  
Hybrid Drugs

Synthesis and investigation of anti-inflammatory activity of novel nitric oxide donating hybrid drugs

2012 ◽  
Vol 22 (7) ◽  
pp. 3510-3517 ◽  
Author(s):  
Shailesh L. Chandak ◽  
Amol S. Bansode ◽  
Prashant R. Murumkar ◽  
Monika G. Shinde ◽  
Kailash G. Bothara
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Activity ◽  
Hybrid Drugs ◽  
Anti Inflammatory

Nitric Oxide Contributes to Adriamycin's Antitumor Effect

1997 ◽  
Vol 69 (2) ◽  
pp. 283-287 ◽  
Author(s):  
D.Scott Lind ◽  
Maria I. Kontaridis ◽  
Paul D. Edwards ◽  
Michael D. Josephs ◽  
Lyle L. Moldawer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antitumor Effect

Can nitric oxide-releasing hybrid drugs alleviate adverse cardiovascular risks?

2013 ◽  
Vol 5 (4) ◽  
pp. 381-383 ◽  
Author(s):  
Atul Bhardwaj ◽  
Jatinder Kaur ◽  
Edward E Knaus
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Risks ◽  
Hybrid Drugs ◽  
Nitric Oxide Releasing

Therapeutic effects of nitric oxide-aspirin hybrid drugs

2006 ◽  
Vol 10 (6) ◽  
pp. 911-922 ◽  
Author(s):  
Catriona M Turnbull ◽  
Adriano G Rossi ◽  
Ian L Megson
Keyword(s):  
Nitric Oxide ◽  
Therapeutic Effects ◽  
Hybrid Drugs

Nitric oxide inhibition, antioxidant, and antitumour activities of novel copper(ii) bis-benzimidazole diamide nanocoordination complexes

2015 ◽  
Vol 39 (6) ◽  
pp. 4316-4327 ◽  
Author(s):  
Manisha Singla ◽  
Rajeev Ranjan ◽  
Kuldeep Mahiya ◽  
Subash C. Mohapatra ◽  
Sharif Ahmad
Keyword(s):  
Nitric Oxide ◽  
Body Weight ◽  
Antitumor Effect ◽  
Nitric Oxide Inhibition ◽  
Weight Difference ◽  
Body Weight Difference ◽  
Oxide Inhibition

Antitumor effect illustrated by changes in body weight. In control mice, body weight increased to 11.5 g but when treated withC3, body weight difference as compared to the control decreased by 4.7 g and decreased to 2.2 g and 0.6 g withC1andC2, respectively.

scholarly journals Multitarget drugs: Focus on the NO-donor hybrid drugs

2008 ◽  
Vol 80 (8) ◽  
pp. 1693-1701 ◽  
Author(s):  
Alberto Gasco ◽  
Donatella Boschi ◽  
Konstantin Chegaev ◽  
Clara Cena ◽  
Antonella Di Stilo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Diseases ◽  
Inflammatory Diseases ◽  
Complex Diseases ◽  
Interesting Case ◽  
No Donor ◽  
Physiological Properties ◽  
Hybrid Drugs ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The article addresses the design of multitarget drugs, namely, compounds capable of interacting with more than one target simultaneously. These agents could be useful tools in the therapy of complex diseases such as cardiovascular and inflammatory diseases. An interesting case of multitarget compounds are nitric oxide (NO)-donor hybrids, structures which combine the physiological properties of NO with those of a lead drug. In particular, the authors discuss the symbiotic approach used to design NO-donor nonsteroidal anti-inflammatory drugs (NO-NSAIDs) and NO-donor antioxidants. The former could be useful agents in the treatment of anti-inflammatory diseases being devoid of gastro- and cardiotoxicity, the latter could be a valid approach to the treatment of many cardiovascular diseases.

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